GRANZYME B
- Product Name
- GRANZYME B
- CAS No.
- 143180-74-9
- Chemical Name
- GRANZYME B
- Synonyms
- GZMB;GRANZYME B;EC 3.4.21.79;GRANZYME B ENZYME;GRANZYME B (HUMAN);Granzyme B from mouse;Granzyme B from Mouse, Recombinant;Granzyme B from Human, Recombinant;Recombinant Mouse Gzmb Protein, His Tag;SensiZyme Granzyme B Activity Assay Kit
- CBNumber
- CB1120279
- Formula Weight
- 0
- MOL File
- Mol file
GRANZYME B Property
- storage temp.
- -70°C
- form
- buffered aqueous solution
N-Bromosuccinimide Price
- Product number
- 356173
- Product name
- GzmB
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- 356174
- Product name
- Gzmb
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- G8957-15E
- Product name
- Granzyme B
- Packaging
- 100ug
- Price
- $645
- Updated
- 2021/12/16
- Product number
- G8957-15B-ML750
- Product name
- Granzyme B
- Packaging
- 100ul
- Price
- $666
- Updated
- 2021/12/16
- Product number
- G8957-15B-ML405
- Product name
- Granzyme B
- Packaging
- 100ul
- Price
- $666
- Updated
- 2021/12/16
GRANZYME B Chemical Properties,Usage,Production
General Description
Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations.
Biochem/physiol Actions
Cytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way.
GRANZYME B Preparation Products And Raw materials
Raw materials
Preparation Products
GRANZYME B Suppliers
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