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AC-DEVD-CHO

Product Name
AC-DEVD-CHO
CAS No.
184179-08-6
Chemical Name
AC-DEVD-CHO
Synonyms
DEVD-CHO;AC-DEVD-CHO;AC-DEVD-ALDEHYDE;CASPASE-3 INHIBITOR;ACETYL-DEVD-ALDEHYDE;CASPASE-3 INHIBITOR I;AC-ASP-GLU-VAL-ASP-CHO;CPP32/APOPAIN INHIBITOR;CELL-PERMEABLE, DEVD-CHO;N-AC-ASP-GLU-VAL-ASP-CHO
CBNumber
CB9488322
Molecular Formula
C20H30N4O11
Formula Weight
502.47
MOL File
184179-08-6.mol
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AC-DEVD-CHO Property

Boiling point:
1021.1±65.0 °C(Predicted)
Density 
1.374±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: 1 mg/mL
form 
powder
pka
4.19±0.10(Predicted)
color 
white
InChIKey
UMBVAPCONCILTL-JQTTWLCSNA-N
SMILES
[C@@H](CCC(=O)O)(NC(=O)[C@@H](NC(=O)C)CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C=O)CC(=O)O |&1:0,9,21,28,r|
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Safety

WGK Germany 
3
Storage Class
10 - Combustible liquids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
235427
Product name
Caspase-3 Inhibitor I, Cell-Permeable
Purity
InSolution, ≥90%
Packaging
1mg
Price
$252
Updated
2025/07/31
Sigma-Aldrich
Product number
235423-M
Product name
Caspase-3 Inhibitor I, Cell-Permeable
Purity
The Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging
1 unit
Price
$244
Updated
2025/07/31
Cayman Chemical
Product number
10017
Product name
Ac-DEVD-CHO
Purity
≥95%
Packaging
500μg
Price
$36
Updated
2021/12/16
Cayman Chemical
Product number
10017
Product name
Ac-DEVD-CHO
Purity
≥95%
Packaging
1mg
Price
$61
Updated
2021/12/16
Cayman Chemical
Product number
10017
Product name
Ac-DEVD-CHO
Purity
≥95%
Packaging
5mg
Price
$230
Updated
2021/12/16
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AC-DEVD-CHO Chemical Properties,Usage,Production

Uses

A cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (Ki<1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.

Definition

ChEBI: Ac-Asp-Glu-Val-Asp-H is a tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7. It has a role as a protease inhibitor.

Biological Activity

Primary Target
caspase-3', 'Target IC50: 200 pM for inhibiting PARP cleavage in cultured human osteosarcoma cell extracts

AC-DEVD-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-DEVD-CHO Suppliers

China 101 France 1 Japan 3 Switzerland 2 United Kingdom 3 United States 15 Global 125
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7408
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
3905209149@qq.com
Country
China
ProdList
9912
Advantage
58
Shanghai Kanglang Biotechnology Co., Ltd.
Tel
021-61998208 18217752821
Fax
021-37680378
Email
sales@klbio.cn
Country
China
ProdList
9621
Advantage
58
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View Lastest Price from AC-DEVD-CHO manufacturers

Hebei ZB Gamay Biological Technology Co.,Ltd
Product
Antibody for Newcastle 184179-08-6
Price
US $26.00/kg
Min. Order
500kg
Purity
99.99%
Supply Ability
20tons
Release date
2024-12-18

184179-08-6, AC-DEVD-CHORelated Search:

Trypsin Proteinase K Urinary Trypsin Inhibitor DISPASE ACHROMOPEPTIDASE MG-115 trysin-chymotrypsin Basic protease PROTEASE N-acetyl aspartyl-glutaMic acid CASPASE-8 INHIBITOR I, CELL-PERMEABLE AC-DEVD-CHO CASPASE-6 INHIBITOR II, CELL-PERMEABLE CASPASE-1 INHIBITOR I, CELL-PERMEABLE Caspase-3 Inhibitor I, Cell-Permeable, in Solution CASPASE-9 INHIBITOR II, CELL-PERMEABLE CASPASE-4 INHIBITOR I, CELL-PERMEABLE CASPASE-1 INHIBITOR I, CELL-PERMEABLE

  • DEVD-CHO
  • CPP32/APOPAIN INHIBITOR
  • CPP32/APOPAIN INHIBITOR, CELL-PERMEABLE
  • CASPASE 3 (APOPAIN) INHIBITOR 1
  • CASPASE-3 INHIBITOR I
  • CASPASE-3 INHIBITOR I, CELL-PERMEABLE
  • CASPASE-3 INHIBITOR
  • CASPASE-3 INHIBITOR (ALDEHYDE)
  • CELL-PERMEABLE, DEVD-CHO
  • AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-ASP-GLU-VAL-ASP-CHO
  • AC-AAVALLPAVLLALLAPDEVD-ALDEHYDE
  • AC-AAVALLPAVLLALLAPDEVD-CHO
  • AC-ASP-GLU-VAL-ASP-ALDEHYDE (PSEUDO ACID)
  • AC-ASP-GLU-VAL-ASP-ALDEHYDE
  • AC-ASP-GLU-VAL-ASP-H (ALDEHYDE)
  • AC-ASP-GLU-VAL-ASP-CHO
  • AC-DEVD-ALDEHYDE
  • AC-DEVD-CHO
  • ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPART-1-AL
  • ACETYL-DEVD-ALDEHYDE
  • ACETYL-ASP-GLU-VAL-ASP-ALDEHYDE
  • N-ACETYL-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-ASP-GLU-VAL-ASP-CHO (ALDEHYDE)
  • N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE)
  • N-AC-ASP-GLU-VAL-ASP-CHO
  • N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-(2-CARBOXY-1-FORMYLETHYL)-L VALINAMIDE
  • CASPASE-3 INHIBITOR I, CELL-PERMEABLE ; AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-ASP-GLU-VAL-ASP-CHO
  • L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-(2-carboxy-1-formylethyl)- (9CI)
  • (4S)-4-((S)-2-amino-3-carboxypropanamido)-5-((2S)-2-(N-(1-carboxy-3-oxopropan-2-yl)acetamido)-3-methylbutanamido)-5-oxopentanoic acid
  • L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-(2-carboxy-1-formylethyl)-
  • 184179-08-6
  • C20H30N4O11
  • 兔抗人、大、小鼠Caspase-10多克隆抗体
  • 多肽抗原
  • Inhibitors
  • BioChemical
  • Caspases
  • Caspase 10
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Apoptosis and Cell Cycle
  • Caspases/Apoptosis