2-CHLORO-4-HYDROXYQUINAZOLINE

Product Name: 2-CHLORO-4-HYDROXYQUINAZOLINE
CAS No.: 607-69-2
Chemical Name: 2-CHLORO-4-HYDROXYQUINAZOLINE
Synonyms: 2-chloroquinazolin-4-ol;2-Chloroquinazolin-4(3H);2-Chloroquinazolin-4-one;2-Chloro-4(1H)-quinazolinone;2-chloroquinazolin-4(1H)-one;2-CHLORO-4-HYDROXYQUINAZOLINE;4(3H)-Quinazolinone, 2-chloro-;2-chloro-3,4-dihydroquinazolin-4-one
CBNumber: CB0741451
Molecular Formula: C8H5ClN2O
Formula Weight: 180.59
MOL File: 607-69-2.mol

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2-CHLORO-4-HYDROXYQUINAZOLINE Property

Melting point:: 218-220℃
Boiling point:: 325.9±25.0 °C(Predicted)
Density: 1.50
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.12±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C429348
Product name: 2-Chloroquinazolin-4(3H)-one
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC142558
Product name: 2-Chloroquinazolin-4(3H)-one
Packaging: 2g
Price: $171
Updated: 2021/12/16

Matrix Scientific

Product number: 119693
Product name: 2-Chloroquinazolin-4(3H)-one
Purity: 95+%
Packaging: 1g
Price: $378
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-5-4E
Product name: 2-Chloro-3H-quinazolin-4-one
Packaging: 250mg
Price: $416
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0068881
Product name: 2-CHLORO-3H-QUINAZOLIN-4-ONE
Purity: 95.00%
Packaging: 5MG
Price: $498.44
Updated: 2021/12/16

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2-CHLORO-4-HYDROXYQUINAZOLINE Chemical Properties,Usage,Production

Uses

2-Chloroquinazolin-4(3H)-one is used in the preparation of some quinazoline derivatives with multiple biological properties.

Synthesis

607-68-1

607-69-2

General procedure for the synthesis of 2-chloroquinazolin-4-one from 2,4-dichloroquinazoline: 2,4-dichloroquinazoline (0.72 g, 3.62 mmol) was dissolved in tetrahydrofuran (6 mL), followed by the addition of aqueous sodium hydroxide solution (8 mL, 1 mol/L). The reaction mixture was stirred and reacted at room temperature overnight. Upon completion of the reaction, the pH of the reaction solution was adjusted to 5-6 with acetic acid to terminate the reaction. The reaction mixture was filtered and the filtrate was concentrated to dryness under reduced pressure to give 2-chloroquinazolin-4-one (0.60 g, 91.9% yield) as a yellow solid.

References

[1] Organic Process Research and Development, 2004, vol. 8, # 3, p. 330 - 340
[2] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 627 - 629
[3] European Journal of Organic Chemistry, 2012, # 11, p. 2118 - 2122
[4] Patent: CN105732591, 2016, A. Location in patent: Paragraph 0311; 0312; 0313; 0314
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300

2-CHLORO-4-HYDROXYQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-HYDROXYQUINAZOLINE Suppliers

Austria 1 China 60 Germany 1 India 1 United Kingdom 2 United States 7 Global 72

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View Lastest Price from 2-CHLORO-4-HYDROXYQUINAZOLINE manufacturers

Career Henan Chemical Co

Product: 2-Chloroquinazolin-4(3H)-one 607-69-2
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

607-69-2, 2-CHLORO-4-HYDROXYQUINAZOLINERelated Search:

4-Hydroxyquinazoline 2,7-DICHLOROQUINAZOLIN-4-OL 2-CHLORO-4,6-DIMETHOXYQUINAZOLINE 2-CHLORO-4-METHOXYQUINAZOLINE 1-((2-Chloro-6,7-dimethoxy-4-quinazolinyl)oxy)-3-((1-methylethyl)amino )-2-propanol 2-CHLORO-6,7-DIMETHOXY-QUINAZOLIN-4-OL 4-(BENZYLOXY)-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE 2-CHLORO-4-HYDROXYQUINAZOLINE

2-CHLORO-4-HYDROXYQUINAZOLINE

4(3H)-Quinazolinone, 2-chloro-

2-Chloro-4(1H)-quinazolinone

2-Chloroquinazolin-4-one

2-chloroquinazolin-4-ol

2-Chloroquinazolin-4(3H)

2-chloro-3,4-dihydroquinazolin-4-one

2-chloroquinazolin-4(1H)-one

607-69-2