ChemicalBook > CAS DataBase List > 2-CHLORO-4-HYDROXYQUINAZOLINE

2-CHLORO-4-HYDROXYQUINAZOLINE

Product Name
2-CHLORO-4-HYDROXYQUINAZOLINE
CAS No.
607-69-2
Chemical Name
2-CHLORO-4-HYDROXYQUINAZOLINE
Synonyms
2-chloroquinazolin-4-ol;2-Chloroquinazolin-4(3H);2-Chloroquinazolin-4-one;2-Chloro-4(1H)-quinazolinone;2-chloroquinazolin-4(1H)-one;2-CHLORO-4-HYDROXYQUINAZOLINE;4(3H)-Quinazolinone, 2-chloro-;2-chloro-3,4-dihydroquinazolin-4-one
CBNumber
CB0741451
Molecular Formula
C8H5ClN2O
Formula Weight
180.59
MOL File
607-69-2.mol
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2-CHLORO-4-HYDROXYQUINAZOLINE Property

Melting point:
218-220℃
Boiling point:
325.9±25.0 °C(Predicted)
Density 
1.50
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.12±0.20(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C429348
Product name
2-Chloroquinazolin-4(3H)-one
Packaging
500mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC142558
Product name
2-Chloroquinazolin-4(3H)-one
Packaging
2g
Price
$171
Updated
2021/12/16
Matrix Scientific
Product number
119693
Product name
2-Chloroquinazolin-4(3H)-one
Purity
95+%
Packaging
1g
Price
$378
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-5-4E
Product name
2-Chloro-3H-quinazolin-4-one
Packaging
250mg
Price
$416
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0068881
Product name
2-CHLORO-3H-QUINAZOLIN-4-ONE
Purity
95.00%
Packaging
5MG
Price
$498.44
Updated
2021/12/16
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2-CHLORO-4-HYDROXYQUINAZOLINE Chemical Properties,Usage,Production

Uses

2-Chloroquinazolin-4(3H)-one is used in the preparation of some quinazoline derivatives with multiple biological properties.

Synthesis

607-68-1

607-69-2

General procedure for the synthesis of 2-chloroquinazolin-4-one from 2,4-dichloroquinazoline: 2,4-dichloroquinazoline (0.72 g, 3.62 mmol) was dissolved in tetrahydrofuran (6 mL), followed by the addition of aqueous sodium hydroxide solution (8 mL, 1 mol/L). The reaction mixture was stirred and reacted at room temperature overnight. Upon completion of the reaction, the pH of the reaction solution was adjusted to 5-6 with acetic acid to terminate the reaction. The reaction mixture was filtered and the filtrate was concentrated to dryness under reduced pressure to give 2-chloroquinazolin-4-one (0.60 g, 91.9% yield) as a yellow solid.

References

[1] Organic Process Research and Development, 2004, vol. 8, # 3, p. 330 - 340
[2] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 627 - 629
[3] European Journal of Organic Chemistry, 2012, # 11, p. 2118 - 2122
[4] Patent: CN105732591, 2016, A. Location in patent: Paragraph 0311; 0312; 0313; 0314
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300

2-CHLORO-4-HYDROXYQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-CHLORO-4-HYDROXYQUINAZOLINE manufacturers

Career Henan Chemical Co
Product
2-Chloroquinazolin-4(3H)-one 607-69-2
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09

607-69-2, 2-CHLORO-4-HYDROXYQUINAZOLINERelated Search:

4-Hydroxyquinazoline 2,7-DICHLOROQUINAZOLIN-4-OL 2-CHLORO-4,6-DIMETHOXYQUINAZOLINE 2-CHLORO-4-METHOXYQUINAZOLINE 1-((2-Chloro-6,7-dimethoxy-4-quinazolinyl)oxy)-3-((1-methylethyl)amino )-2-propanol 2-CHLORO-6,7-DIMETHOXY-QUINAZOLIN-4-OL 4-(BENZYLOXY)-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE 2-CHLORO-4-HYDROXYQUINAZOLINE

  • 2-CHLORO-4-HYDROXYQUINAZOLINE
  • 4(3H)-Quinazolinone, 2-chloro-
  • 2-Chloro-4(1H)-quinazolinone
  • 2-Chloroquinazolin-4-one
  • 2-chloroquinazolin-4-ol
  • 2-Chloroquinazolin-4(3H)
  • 2-chloro-3,4-dihydroquinazolin-4-one
  • 2-chloroquinazolin-4(1H)-one
  • 607-69-2