ChemicalBook > CAS DataBase List > 1-Bromo-4-chlorobutane

1-Bromo-4-chlorobutane

Product Name
1-Bromo-4-chlorobutane
CAS No.
6940-78-9
Chemical Name
1-Bromo-4-chlorobutane
Synonyms
4-BROMOBUTYL CHLORIDE;NAPRO-008;1-Bromo-4-chL;1-Brom-4-chlorbutan;4-CHLOROBUTYL BROMIDE;1-Bromo-4-chloroutane;4-CHLORO-1-BROMOBUTANE;1-BROMO-4-CHLOROBUTANE;1-bromo-4-chloro-butan;1-Chloro-4-bromobutane
CBNumber
CB0753483
Molecular Formula
C4H8BrCl
Formula Weight
171.46
MOL File
6940-78-9.mol
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1-Bromo-4-chlorobutane Property

Melting point:
96-97 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
Boiling point:
80-82 °C/30 mmHg (lit.)
Density 
1.488 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4875(lit.)
Flash point:
140 °F
storage temp. 
Store below +30°C.
solubility 
soluble in Chloroform
form 
Liquid
color 
Clear
Water Solubility 
SLIGHTLY SOLUBLE
BRN 
1098275
InChIKey
NIDSRGCVYOEDFW-UHFFFAOYSA-N
CAS DataBase Reference
6940-78-9(CAS DataBase Reference)
NIST Chemistry Reference
Butane, 1-bromo-4-chloro-(6940-78-9)
EPA Substance Registry System
Butane, 1-bromo-4-chloro- (6940-78-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-37/39-26
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29034980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B60800
Product name
1-Bromo-4-chlorobutane
Purity
99%
Packaging
25g
Price
$46.4
Updated
2025/07/31
Sigma-Aldrich
Product number
B60800
Product name
1-Bromo-4-chlorobutane
Purity
99%
Packaging
100g
Price
$154
Updated
2025/07/31
TCI Chemical
Product number
B1345
Product name
1-Bromo-4-chlorobutane
Purity
>99.0%(GC)
Packaging
25g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
B1345
Product name
1-Bromo-4-chlorobutane
Purity
>99.0%(GC)
Packaging
500g
Price
$239
Updated
2025/07/31
TRC
Product number
B682650
Product name
1-Bromo-4-chlorobutane
Packaging
25g
Price
$215
Updated
2021/12/16
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1-Bromo-4-chlorobutane Chemical Properties,Usage,Production

Chemical Properties

clear liquid

Uses

1-Bromo-4-chlorobutane is used as a reagent in the synthesis of a novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.

Synthesis

30379-55-6

109-70-6

6940-78-9

1. n-Butyllithium (1.6 M hexane solution, 5.0 mL, 8.0 mmol) was added slowly and dropwise to a tetrahydrofuran (THF, 10 mL) solution of diisopropylamine (1.1 mL, 8.0 mmol) at -30 °C and stirred continuously for 30 min at this temperature. 2. the reaction system was cooled down to -70 °C, a solution of (benzyloxy)acetic acid (0.60 g, 3.6 mmol) in THF (5 mL) was added slowly dropwise and stirred for 30 min at the same temperature. 3. Maintaining the -70 °C condition, 1-bromo-3-chloropropane (3.6 mL, 36 mmol) was added to the reaction mixture and stirring was continued for 30 minutes before the reaction system was slowly warmed to room temperature and stirred for 2 hours. 4. The reaction mixture was poured into ice-cold water and washed with ethyl acetate. 5. The pH of the aqueous layer was adjusted to 3-4 with 6 M hydrochloric acid and the mixture was subsequently extracted with ethyl acetate. 6. The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. 7. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 100/0 to 50/50 gradient elution) to afford 1-bromo-4-chlorobutane as a colorless oil (0.28 g, 32% yield). 8. The structure of the product was investigated by 1H NPD analysis. 8. The structure of the product was confirmed by 1H NMR (CDCl3): δ 1.91-2.06 (4H, m), 3.54 (2H, t, J=5.1 Hz), 4.08 (1H, t, J=6.6 Hz), 4.55 and 4.74 (2H, d, J=11.4 Hz), 7.34-7.39 (5H, m).

References

[1] Patent: EP2455380, 2012, A1. Location in patent: Page/Page column 79

1-Bromo-4-chlorobutane Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Bromo-4-chlorobutane Suppliers

Americas 1 Belgium 1 Canada 1 China 361 Europe 2 France 1 Germany 5 India 12 Italy 1 Japan 4 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 8 United States 30 Global 431
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
13396369453 QQ3007939906 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
906
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58
Weifang Weimeng Chemical Co., Ltd.
Tel
QQ 1340191485 15105445095
Email
weimengchem@163.com
Country
China
ProdList
482
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58
Chizhou Bluesky Chemical Co., Ltd.
Tel
15996451730
Email
719225026@qq.com
Country
China
ProdList
30
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58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
ProdList
40228
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
ProdList
15838
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Anqing PhiChem Corporation
Tel
0556-5209970
Fax
0556-5209971
Email
salesaq@phichem.com.cn
Country
China
ProdList
36
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
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24529
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81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
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View Lastest Price from 1-Bromo-4-chlorobutane manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-Bromo-4-chlorobutane 6940-78-9
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-11
Hebei Chuanghai Biotechnology Co., Ltd
Product
1-Bromo-4-chlorobutane 6940-78-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-20
Hebei Zhuanglai Chemical Trading Co Ltd
Product
1-Bromo-4-chlorobutane 6940-78-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-11

6940-78-9, 1-Bromo-4-chlorobutaneRelated Search:

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