NECA

Product Name: NECA
CAS No.: 35920-39-9
Chemical Name: NECA
Synonyms: NECA;D-NECA;744-96;765-21;B-744-96;NECA USP/EP/BP;5'-ETHYLCARBOXAMIDOADENOSINE;5’-EthylcarboxamidoAdenosine;Adenosine-5'-ethylcarboxamide;5'-N-Ethylcarboxamideadenosine
CBNumber: CB0763077
Molecular Formula: C12H16N6O4
Formula Weight: 308.29
MOL File: 35920-39-9.mol

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NECA Property

Melting point:: 229-231°C
Density: 1.87±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4°C.
pka: 12.93±0.70(Predicted)
form: powder
color: white
Stability:: Hygroscopic
InChIKey: JADDQZYHOWSFJD-FLNNQWSLSA-N
CAS DataBase Reference: 35920-39-9

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Safety

Hazard Codes: T+
Risk Statements: 28
Safety Statements: 22-26-36-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: VJ2232000
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E2387
Product name: 5′-(N-Ethylcarboxamido)adenosine
Purity: powder
Packaging: 50mg
Price: $223
Updated: 2024/03/01

Sigma-Aldrich

Product number: 119140
Product name: Adenosine Receptor Agonist, NECA
Packaging: 10mg
Price: $69
Updated: 2024/03/01

Alfa Aesar

Product number: J60405
Product name: 5'-N-Ethylcarboxamidoadenosine
Packaging: 10mg
Price: $83
Updated: 2021/12/16

Alfa Aesar

Product number: J60405
Product name: 5'-N-Ethylcarboxamidoadenosine
Packaging: 50mg
Price: $351
Updated: 2021/12/16

Cayman Chemical

Product number: 21420
Product name: 5'-N-Ethylcarboxamidoadenosine
Purity: ≥99%
Packaging: 5mg
Price: $25
Updated: 2021/12/16

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NECA Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo

Uses

Potent adenosine receptor agonist with some affinity at A1 and A2 receptors

Uses

5′-(N-Ethylcarboxamido)adenosine has been used:

for the purification of human adenosine A_2Areceptor (A_2AR) in decylmaltoside (DM)
to determine nonspecific binding of adenosine receptors
to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay

Definition

ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.

General Description

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K_i = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A₁, A_2A, A_2B, A₃, respectively). Increases intracellular cAMP production (EC₅₀ = 3.1 μM in A_2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.

Biological Activity

Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .

Biochem/physiol Actions

Reversible: yes

storage

Store at +4°C

NECA Preparation Products And Raw materials

Raw materials

Preparation Products

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NECA Suppliers

Canada 1 China 73 China Hong Kong 1 Germany 2 India 1 Russia 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 15 Global 100

Shanghai Pullins Pharmaceutical Technology Co., LTD

Tel: 021-68080657 15921562525
Email: 37130379@qq.com
Country: China
ProdList: 48
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 17987
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10269
Advantage: 58

Chengdu NoVi Biotechnology Co., Ltd.

Tel: 028-81458053
Fax: 028-81458053
Email: novibiotech@163.com sales@novi-biotech.com
Country: China
ProdList: 226
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4619
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

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View Lastest Price from NECA manufacturers

Career Henan Chemical Co

Product: NECA 35920-39-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 562
Release date: 2019-09-01

35920-39-9, NECARelated Search:

he-neca 2-IODO-NECA 5'-EthylcarboxaMido-2',3'-isopropylidene Adenosine 2-Chloro-NECA NECA 5'-N-[ADENINE-2,8-3H]- N6-BENZYL-NECA CGS 21680, [CARBOXYETHYL-3H(N)]- 2-CHLORO-2',3'-O-ISOPROPYLIDENEADENOSINE-5'-N-ETHYLCARBOXAMIDE EB-47 DIHYDROCHLORIDE DIHYDRATE CGS 21680 NECA 5'-(N-CYCLOPROPYL)CARBOXAMIDOADENOSINE DANSYL-NECA 5'-N-ETHYLCARBOXAMIDOADENOSINE, [ADENINE-2,8-3H]- CGS-21680 HYDROCHLORIDE

5'-N6-Ethylcarboxamidoadenosine

5'-ETHYLCARBOXAMIDOADENOSINE

1-(6-AMINO-9H-PURIN-9-YL)-1-DEOXY-N-ETHYL-BETA-D-RIBOFURANURONAMIDE

1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethylribofuranuronamidehemihydrate

1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethyl-ribofuranuronamidhemihydrate

5’-n(sup6)-ethylcarboxamidoadenosinehemihydrate

5’-n-ethylcarboxamidoadenosinehemihydrate

adenosine-5’-(n-ethyl)carboxamidehemihydrate

adenosine-5’-(n-ethylcarboxamide

NECA

b-D-RibofuranuronaMide, 1-(6-aMino-9H-purin-9-yl)-1-deoxy-N-ethyl-

D-NECA

NECA,5′-(N-Ethylcarboxamido)adenosine

Adenosine Receptor Agonist, NECA

5'-(N-ETHYLCARBOXAMIDO)-ADENOSINE

1-(6-Amino-(9H)-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamide

NECA, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-D-ribofuranuronamide

5'-Ethylcarboxamido-D-adenosine

5'-N-Ethylcarboxamideadenosine

744-96

765-21

Adenosine-5'-ethylcarboxamide

B-744-96

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide

N-ethyl-5'-carboxamidoadenosine

Adenosine Receptor Agonist, NECA - CAS 35920-39-9 - Calbiochem

β-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-

NECA USP/EP/BP

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide

5’-EthylcarboxamidoAdenosine

35920-39-9

C12H16N6O4

Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.

Bases & Related Reagents

Inhibitors

Nucleotides

Adenosine receptor