ChemicalBook > CAS DataBase List > NECA

NECA

Product Name
NECA
CAS No.
35920-39-9
Chemical Name
NECA
Synonyms
NECA;D-NECA;744-96;765-21;B-744-96;NECA USP/EP/BP;NECA, adenosine agonist;5'-ETHYLCARBOXAMIDOADENOSINE;5’-EthylcarboxamidoAdenosine;Adenosine-5'-ethylcarboxamide
CBNumber
CB0763077
Molecular Formula
C12H16N6O4
Formula Weight
308.29
MOL File
35920-39-9.mol
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NECA Property

Melting point:
229-231°C
Density 
1.87±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4°C.
pka
12.93±0.70(Predicted)
form 
powder
color 
white
Stability:
Hygroscopic
InChIKey
JADDQZYHOWSFJD-FLNNQWSLSA-N
CAS DataBase Reference
35920-39-9
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Safety

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
22-26-36-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
VJ2232000
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E2387
Product name
5′-(N-Ethylcarboxamido)adenosine
Purity
powder
Packaging
50mg
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
119140
Product name
Adenosine Receptor Agonist, NECA
Packaging
10mg
Price
$69
Updated
2024/03/01
Alfa Aesar
Product number
J60405
Product name
5'-N-Ethylcarboxamidoadenosine
Packaging
10mg
Price
$83
Updated
2021/12/16
Alfa Aesar
Product number
J60405
Product name
5'-N-Ethylcarboxamidoadenosine
Packaging
50mg
Price
$351
Updated
2021/12/16
Cayman Chemical
Product number
21420
Product name
5'-N-Ethylcarboxamidoadenosine
Purity
≥99%
Packaging
5mg
Price
$25
Updated
2021/12/16
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NECA Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo

Uses

Potent adenosine receptor agonist with some affinity at A1 and A2 receptors

Uses

5′-(N-Ethylcarboxamido)adenosine has been used:

  • for the purification of human adenosine A2Areceptor (A2AR) in decylmaltoside (DM)
  • to determine nonspecific binding of adenosine receptors
  • to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay

Definition

ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.

General Description

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1 μM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.

Biological Activity

Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .

Biochem/physiol Actions

Reversible: yes

storage

Store at +4°C

NECA Preparation Products And Raw materials

Raw materials

Preparation Products

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NECA Suppliers

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View Lastest Price from NECA manufacturers

Career Henan Chemical Co
Product
NECA 35920-39-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 562
Release date
2019-09-01

35920-39-9, NECARelated Search:

he-neca 2-IODO-NECA 5'-EthylcarboxaMido-2',3'-isopropylidene Adenosine 2-Chloro-NECA NECA 5'-N-[ADENINE-2,8-3H]- N6-BENZYL-NECA CGS 21680, [CARBOXYETHYL-3H(N)]- 2-CHLORO-2',3'-O-ISOPROPYLIDENEADENOSINE-5'-N-ETHYLCARBOXAMIDE EB-47 DIHYDROCHLORIDE DIHYDRATE CGS 21680 NECA 5'-(N-CYCLOPROPYL)CARBOXAMIDOADENOSINE DANSYL-NECA 5'-N-ETHYLCARBOXAMIDOADENOSINE, [ADENINE-2,8-3H]- CGS-21680 HYDROCHLORIDE

  • 5'-N6-Ethylcarboxamidoadenosine
  • 5'-ETHYLCARBOXAMIDOADENOSINE
  • 1-(6-AMINO-9H-PURIN-9-YL)-1-DEOXY-N-ETHYL-BETA-D-RIBOFURANURONAMIDE
  • 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethylribofuranuronamidehemihydrate
  • 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethyl-ribofuranuronamidhemihydrate
  • 5’-n(sup6)-ethylcarboxamidoadenosinehemihydrate
  • 5’-n-ethylcarboxamidoadenosinehemihydrate
  • adenosine-5’-(n-ethyl)carboxamidehemihydrate
  • adenosine-5’-(n-ethylcarboxamide
  • NECA
  • b-D-RibofuranuronaMide, 1-(6-aMino-9H-purin-9-yl)-1-deoxy-N-ethyl-
  • D-NECA
  • NECA,5′-(N-Ethylcarboxamido)adenosine
  • Adenosine Receptor Agonist, NECA
  • 5'-(N-ETHYLCARBOXAMIDO)-ADENOSINE
  • 1-(6-Amino-(9H)-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamide
  • NECA, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-D-ribofuranuronamide
  • 5'-Ethylcarboxamido-D-adenosine
  • 5'-N-Ethylcarboxamideadenosine
  • 744-96
  • 765-21
  • Adenosine-5'-ethylcarboxamide
  • B-744-96
  • 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide
  • N-ethyl-5'-carboxamidoadenosine
  • Adenosine Receptor Agonist, NECA - CAS 35920-39-9 - Calbiochem
  • β-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-
  • NECA USP/EP/BP
  • 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide
  • 5’-EthylcarboxamidoAdenosine
  • 5'-N-Ethylcarboxamidoadenosine
  • 5'-N-Ethylcarboxamidoadenosine (NECA)
  • (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide
  • NECA, adenosine agonist
  • 35920-39-9
  • C12H16N6O4
  • Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.
  • Bases & Related Reagents
  • Inhibitors
  • Nucleotides
  • Adenosine receptor