(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

Reactions

Product Name: (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
CAS No.: 112022-83-0
Chemical Name: (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
Synonyms: (R)-2-METHYL-CBS-OXAZABOROLIDINE;(R)-ME CBS;(R)-METHYL OXAZABOROLIDINE;(R)-1-Methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole;idine;(R)-Me-CBS Catalyst;2-c][1;(R)-1-METH;3H-pyrrolo[1;2]oxazaborole
CBNumber: CB0763916
Molecular Formula: C18H20BNO
Formula Weight: 277.17
MOL File: 112022-83-0.mol

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(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Property

Melting point:: 85-95 °C(lit.)
Boiling point:: 111 °C
Density: 0.95 g/mL at 25 °C
refractive index: 68 ° (C=1, MeOH)
Flash point:: 40 °F
storage temp.: room temp
solubility: soluble in Chloroform, Methanol
pka: 1.02±0.40(Predicted)
form: Liquid
color: Colorless to amber
optical activity: [α]22/D +76.8°, c = 1 in toluene
Water Solubility: Not miscible or difficult to mix in water.
Sensitive: Air & Moisture Sensitive
BRN: 9059874
Exposure limits: ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
InChIKey: VMKAFJQFKBASMU-QGZVFWFLSA-N
CAS DataBase Reference: 112022-83-0(CAS DataBase Reference)

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Safety

Hazard Codes: F,Xn,Xi
Risk Statements: 11-38-48/20-63-65-67-36/37-19-40
Safety Statements: 36/37-62-33-29-16-2-26
RIDADR: UN 1294 3/PG 2
WGK Germany: 3
F: 10
HazardClass: 3
PackingGroup: II
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 457698
Product name: (R)-(+)-2-Methyl-CBS-oxazaborolidine solution
Purity: 1 M in toluene
Packaging: 5ml
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: 457698
Product name: (R)-(+)-2-Methyl-CBS-oxazaborolidine solution
Purity: 1 M in toluene
Packaging: 25ml
Price: $408
Updated: 2024/03/01

TCI Chemical

Product number: D2130
Product name: (R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine
Purity: >97.0%(T)
Packaging: 1g
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: D2130
Product name: (R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine
Purity: >97.0%(T)
Packaging: 5g
Price: $116
Updated: 2024/03/01

Alfa Aesar

Product number: L09230
Product name: (R)-2-Methyl-CBS-oxazaborolidine monohydrate, 94%
Packaging: 1g
Price: $83.5
Updated: 2021/12/16

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(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Chemical Properties,Usage,Production

Reactions

Convenient catalyst for the enantioselective borane reduction of ketones at ambient temperatures.
Asymmetric synthesis of α-chiral hydroxyalkylphosphines via a catalytic, enantioselective reduction of acylphosphines.
Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: Stereospecific formation of diarylalkanes and triarylmethanes.
Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS.

Chemical Properties

white to light yellow crystal powde

Uses

suzuki reaction

Uses

(R)-2-Methyl-CBS-oxazaborolidine is used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2 symmetrical ferrocenyl diols, and propargyl alcohols. It is also used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone. It is useful in the production of stereospecific motifs such as α-hydroxy acids, α-amino acids, symmetrical ferrocenyl diols and propargyl alcohols.

Uses

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis

(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Preparation Products And Raw materials

Raw materials

Preparation Products

4H-AMINO-6-BROMO-2,3-DIHYDROTHIOCHROMEN-1,1-DIOXIDE 4-Hydroxy-6-bromo-2,3-dihydrothiochromen-1,1-dioxide

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View Lastest Price from (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole 112022-83-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2021-11-09

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole 112022-83-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole 112022-83-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

112022-83-0, (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaboroleRelated Search:

2-Methyl-1-propanol Piperazine n-Butyllithium Potassium pyrophosphate Tetrahydrofuran Benzoic acid Sodium sulfide 2-Amino-2-methyl-1-propanol CATECHOLBORANE N-Benzylcinchonidinium chloride ent-EzetiMibe EzetiMibe (3R,4R,3'S)-IsoMer (R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one (3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one 4a€-O-Benzyloxy (3S,4S)-Ezetimibe (4S)-3-(2,2-dimethylpropanoyl)-4-phenyl-1,3-oxazolidin-2-one 4-BENZOYLBUTYRIC ACID 2-Oxazolidinone, 3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-, (4S)-rel-

ALPHA,ALPHA-DIPHENYL-D-PROLINOL METHYLBORONIC ACID CYCL-AMIDE-ESTER

(R)-(+)-2-METHYL-CBS-OXAZABOROLIDINE

(R)-Methyloxazaborolidine,1-1.5Mintoluene[(R)-MeCBS]CoreyCatalyst

(r)-(+)-2-methyl-cbs-oxazaborolidine solution

(r)-2-methyl-cbs-oxazaborolidine, 1m soln. in toluene

α,α-diphenyl-d-prolinol methylboronic acid cycl-amide-ester

α,α-diphenyl-d-prolinolmethylboronic acid cyclamide ester

(R)-(+)-Methyl-CBS-oxazaborolidine

(R)-Me-CBS Catalyst

α,α-Diphenyl-D-prolinolmethylboronic acid cyclamide ester, (R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-Methyl,3,3-diphenyl-tetrahydro-pyrrolo(1,2-c)(1,3,2)oxazaborole

(R-Methyl-Corey-Bakshi-Shibata catalyst

(R)-Tetrahydro-1-methyl-3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 1-1.5M in toluene [(R)-Methyl oxazaborolidine] Corey Catalyst

(3aR)-1-Methyl-3,3-diphenyl-3aα,4,5,6-tetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole

(3aR)-3,3aα,4,5-Tetrahydro-1-methyl-3,3-diphenyl-6H-1-bora-2-oxa-6a-azapentalene

(3aR)-3,3-Diphenyl-1-methyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole

(3aR)-Tetrahydro-1-methyl-3,3-diphenyl-3H-pyrrolo[1,2-c][1,3,2]oxazaborole

(5R)-2-Methyl-4,4-diphenyl-1-aza-2-bora-3-oxabicyclo[3.3.0]octane

1-Methyl-3,3-diphenyl-3aα,4,5,6-tetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole

(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

(R)-TETRAHYDRO-1-METHYL-1,3-DIPHENYL-1H,3H-PYRROLO[1,2-C][1,3,2]OXAZOBOROLE

(R)-(+)-2-Methyl-CBS-oxazaborolidine >=95%

(R)-(+)-2-Methyl-CBS-oxazaborolidine solution 1 M in THF

(R)-(+)-2-Methyl-CBS-oxazaborolidine solution 1 M in toluene

(R)-(+)-2-Methyl-CBS-oxazaborolindine

(R)-2-Methyl-CBS-oxazaborolidine (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

(R)-2-Methyl-CBS-oxazaborolidine (1mol/L)

(R)-2-Methyl-CBS-oxazaborolidine (solid)

(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 0.9-1.1M in toluene [(R)-Methyloxazaborolidine]

(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 0.9-1.1M in toluene [(R)-Methyloxazaborolidine] (R)-CBS Catalyst

(R)- METHYL OXAZABOROLIDINE IN TOLUENE 1M. IN CYLINDER

(R)-1-METHYL,3,3-

(R)-1-METH

(R)-2-METHYL-CBS-OXAZABOROLIDINE

(R)-2-METHYL-CBS-OXAZABOROLIDINE MONOHYDRATE

(R)-1-METHYL,3,3-DIPHENYL-TETRAHYDRO-PYRROLO(1,2-C)(1,3,2)OXAZABOROLE

(R)-3,3-DIPHENYL-1-METHYLTETRAHYDRO-1H,3H-PYRROLO[1,2-C][1,3,2]OXAZABOROLE

(R)-3,3-DIPHENYL-1-METHYLTETRAHYDRO-3H-PYRROLO-[1,2-C][1,3,2]OXAZABOROLE

(R)-5,5-DIPHENYL-2-METHYL-3,4-PROPANO-1,3,2-OXAZABOROLIDINE

(R)-TETRAHYDRO-1-METHYL-3,3-DIPHENYL-1H,3H-PYRROLO[1,2-C][1,3,2] OXAZABOROLE

(R)-TETRAHYDRO-1-METHYL-3,3-DIPHENYL-1H,3H-PYRROLO[1,2-C][1,3,2]OXAZOBOROLE

(R)-ME CBS

(R)-METHYL OXAZABOROLIDINE

(R)-methyloxazaborolidine,(R)-mecbs,in

(R)-methyloxazaborolidine,(R)-mecbs,intoluene

(R)-Methyloxazaborolidine,1-1.5Mintoluene[(R)-MeCBS]

( R )-2-Methyl-CBS-Oxazaborolidine.H20

(R)-Methyl oxazaborolidine, in toluene, 1M solution

(R)-(+)-2-METHYL-CBS-OXAZABOROLIDINE, 1M SOLUTION IN TOLUENE

(R)-2-METHYL-CBS-OXAZABOROLIDINE, 1M IN&

(R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborlidine

(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole,0.9-1.1Mintoluene[(R)-Methyloxazaborolidine]CoreyCatalyst

(R)-Tetrahydro-1-Methyl-3

0.9-1.1Mintoluene[(R)-Methyloxazaborolidine]CoreyCatalyst

2]oxazaborole

2-c][1

3-diphenyl-1H

3H-pyrrolo[1

(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrole[1,2-c][1,3,2]oxazaborole, 0.9-1.1M in toluene [(R)-Methyloxazaborolidine] Corey Catalyst