6',7'-DIHYDROXYBERGAMOTTIN
- Product Name
- 6',7'-DIHYDROXYBERGAMOTTIN
- CAS No.
- 145414-76-2
- Chemical Name
- 6',7'-DIHYDROXYBERGAMOTTIN
- Synonyms
- 6',7'-DIHYDROXYBERGAMOTTIN;6,7-dihydroxybergaMottin(DHB);4-[[(2E)-6,7-Dihydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-6,7-dihydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-
- CBNumber
- CB0765541
- Molecular Formula
- C21H24O6
- Formula Weight
- 372.41
- MOL File
- 145414-76-2.mol
6',7'-DIHYDROXYBERGAMOTTIN Property
- Melting point:
- 112-113 °C
- Boiling point:
- 578.2±50.0 °C(Predicted)
- Density
- 1.260
- storage temp.
- 2-8°C
- solubility
- ethanol: soluble
- pka
- 14.65±0.29(Predicted)
- form
- Solid
- color
- white to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- UC441
- Product name
- 6,-7-Dihydroxybergamottin
- Packaging
- 5mg
- Price
- $896
- Updated
- 2024/03/01
- Product number
- UC441
- Product name
- 6,-7-Dihydroxybergamottin
- Packaging
- 10mg
- Price
- $1520
- Updated
- 2022/05/15
- Product number
- 10009598
- Product name
- 6,7-dihydroxy Bergamottin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $20
- Updated
- 2024/03/01
- Product number
- 10009598
- Product name
- 6,7-dihydroxy Bergamottin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 10009598
- Product name
- 6,7-dihydroxy Bergamottin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $146
- Updated
- 2024/03/01
6',7'-DIHYDROXYBERGAMOTTIN Chemical Properties,Usage,Production
Description
6,7-
Uses
6′,7′-dihydroxybergamottin has been used to study its effect on the inhibition of cytochrome P450 (CYP)-mediated triazolam hydroxylation in dog liver microsomes.
Uses
A minor metabolite of Bergamottin. Metabolization of Bergamottin by cytochromes P 450 2B6 and 3A5.
Uses
A minor metabolite of Bergamottin (B318400). Metabolization of Bergamottin by cytochromes P 450 2B6 and 3A5.
Definition
ChEBI: 6',7'-Dihydroxybergamottin is a member of psoralens.
Biochem/physiol Actions
CYP3A4 inhibitor.
in vitro
6,7-dhb significantly blocked the testosterone 6β-hydrolase in human liver microsomes and human cyp3a4 expressed in escherichia coli membrane in a time- and concentration-dependent manner. furthermore, 6,7-dhb proved to be a potent nadph- and time-dependent inhibitor of cyp3a4 [1]. 6,7-dhb concentration-dependently inhibited nifedipine (nfp) oxidation in hepg2-gs-3a4 cell, a cell line from hepatoblastoma with overexpression of human cyp3a4 [2].
in vivo
male wistar-st rats were intraduodenally administered with 6,7-dhb at a dose of 3.4 mg/ml. after 4 hours, 6,7-dhb had no significant effects on the nfp plasma concentrations, suggesting that 6,7-dhb had no pharmacokinetic effect on the rats [3].
IC 50
25 μm
References
[1]. bellevue, f., woster, p., edwards, d., he, k., & hollenberg, p. synthesis and biological evaluation of 6′,7′-dihydroxybergamottin (6,7-dhb), a naturally occurring inhibitor of cytochrome p450 3a4. bioorganic & medicinal chemistry letters. 1997; 7(20): 2593-2598.
[2]. araki, n., tsuruoka, s., hasegawa, g., yanagihara, h., omasa, t., & enosawa, s. et al. inhibition of cyp3a4 by 6′,7′-dihydroxybergamottin in human cyp3a4 over-expressed hepg2 cells. journal of pharmacy and pharmacology. 2012; 64(12): 1715-1721.
[3]. mohri, k., & uesawa, y. effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats. pharmaceutical research, 2001;18(2):177-182.
6',7'-DIHYDROXYBERGAMOTTIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6',7'-DIHYDROXYBERGAMOTTIN manufacturers
- Product
- 6',7'-DIHYDROXYBERGAMOTTIN 145414-76-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14