ChemicalBook > CAS DataBase List > 6',7'-DIHYDROXYBERGAMOTTIN

6',7'-DIHYDROXYBERGAMOTTIN

Product Name: 6',7'-DIHYDROXYBERGAMOTTIN
CAS No.: 145414-76-2
Chemical Name: 6',7'-DIHYDROXYBERGAMOTTIN
Synonyms: 6',7'-DIHYDROXYBERGAMOTTIN;6,7-dihydroxybergaMottin(DHB);4-[[(2E)-6,7-Dihydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-6,7-dihydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-
CBNumber: CB0765541
Molecular Formula: C21H24O6
Formula Weight: 372.41
MOL File: 145414-76-2.mol

Less

6',7'-DIHYDROXYBERGAMOTTIN Property

Melting point:: 112-113 °C
Boiling point:: 578.2±50.0 °C(Predicted)
Density: 1.260
storage temp.: 2-8°C
solubility: ethanol: soluble
pka: 14.65±0.29(Predicted)
form: Solid
color: white to off-white

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: UC441
Product name: 6,-7-Dihydroxybergamottin
Packaging: 5mg
Price: $921
Updated: 2025/07/31

Sigma-Aldrich

Product number: UC441
Product name: 6,-7-Dihydroxybergamottin
Packaging: 10mg
Price: $1520
Updated: 2022/05/15

Cayman Chemical

Product number: 10009598
Product name: 6,7-dihydroxy Bergamottin
Purity: ≥98%
Packaging: 1mg
Price: $20
Updated: 2024/03/01

Cayman Chemical

Product number: 10009598
Product name: 6,7-dihydroxy Bergamottin
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 10009598
Product name: 6,7-dihydroxy Bergamottin
Purity: ≥98%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

Less

6',7'-DIHYDROXYBERGAMOTTIN Chemical Properties,Usage,Production

Description

6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC₅₀ = 25 μM). It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents. However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.

Uses

6′,7′-dihydroxybergamottin has been used to study its effect on the inhibition of cytochrome P450 (CYP)-mediated triazolam hydroxylation in dog liver microsomes.

Uses

A minor metabolite of Bergamottin. Metabolization of Bergamottin by cytochromes P 450 2B6 and 3A5.

Uses

A minor metabolite of Bergamottin (B318400). Metabolization of Bergamottin by cytochromes P 450 2B6 and 3A5.

Definition

ChEBI: 6',7'-Dihydroxybergamottin is a member of psoralens.

Biochem/physiol Actions

CYP3A4 inhibitor.

in vitro

6,7-dhb significantly blocked the testosterone 6β-hydrolase in human liver microsomes and human cyp3a4 expressed in escherichia coli membrane in a time- and concentration-dependent manner. furthermore, 6,7-dhb proved to be a potent nadph- and time-dependent inhibitor of cyp3a4 [1]. 6,7-dhb concentration-dependently inhibited nifedipine (nfp) oxidation in hepg2-gs-3a4 cell, a cell line from hepatoblastoma with overexpression of human cyp3a4 [2].

in vivo

male wistar-st rats were intraduodenally administered with 6,7-dhb at a dose of 3.4 mg/ml. after 4 hours, 6,7-dhb had no significant effects on the nfp plasma concentrations, suggesting that 6,7-dhb had no pharmacokinetic effect on the rats [3].

IC 50

25 μm

References

[1]. bellevue, f., woster, p., edwards, d., he, k., & hollenberg, p. synthesis and biological evaluation of 6′,7′-dihydroxybergamottin (6,7-dhb), a naturally occurring inhibitor of cytochrome p450 3a4. bioorganic & medicinal chemistry letters. 1997; 7(20): 2593-2598.
[2]. araki, n., tsuruoka, s., hasegawa, g., yanagihara, h., omasa, t., & enosawa, s. et al. inhibition of cyp3a4 by 6′,7′-dihydroxybergamottin in human cyp3a4 over-expressed hepg2 cells. journal of pharmacy and pharmacology. 2012; 64(12): 1715-1721.
[3]. mohri, k., & uesawa, y. effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats. pharmaceutical research, 2001;18(2):177-182.

6',7'-DIHYDROXYBERGAMOTTIN Preparation Products And Raw materials

Raw materials

Preparation Products

Less

6',7'-DIHYDROXYBERGAMOTTIN Suppliers

Canada 1 China 49 India 1 Switzerland 1 United Kingdom 2 United States 6 Global 60

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Wuhan Kemi-Works Chemical Co., Ltd

Tel: 027-85736489
Fax: 86-27-85736485
Email: info@kemiworks.net
Country: China
ProdList: 540
Advantage: 57

Wuhan HengHeDa Pharm Co., Ltd.

Tel: 027-84888681 18086046872
Fax: 027-84888682
Email: hhdpharm@hotmail.com
Country: China
ProdList: 105
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Wuhan Kemi-Works Chemical Co., Ltd.

Tel: +86-2785736489 +8618171418573
Email: sales@kemiworks.com
Country: China
ProdList: 782
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7974
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9847
Advantage: 58

Hubei Baidu Chemical Co., Ltd

Tel: 027-027-59106051 13627137652
Fax: 027-59223020
Email: 1438180055@qq.com
Country: China
ProdList: 8750
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Hubei Chenghai Chemical Co., Ltd

Tel: 027-59220433 18327245847
Email: 1400838877@qq.com
Country: China
ProdList: 9875
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9654
Advantage: 58

GAMI TECHNOLOGY (QINGDAO) CO.,LTD.

Tel: 19524370118
Email: sales@gamichem.com
Country: China
ProdList: 3017
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Shanghai Zheyan Biotech Co., Ltd.

Tel: 18017610038
Email: zheyansh@163.com
Country: CHINA
ProdList: 3619
Advantage: 58

Zibo Hangyu Biotechnology Development Co., Ltd

Tel: +86-0533-2185556 +8615965530500
Email: nickzhang@hangyubiotech.com
Country: China
ProdList: 8510
Advantage: 58

Chongqing jooe co., ltd

Tel: +undefined86-15223382610
Email: info@jooe.com
Country: China
ProdList: 6208
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Wuhan Nutra Biotechnology Co.,Ltd

Tel: +8617786394783
Email: nutrabiotech@outlook.com
Country: China
ProdList: 300
Advantage: 58

Guangzhou Squirrel Biotechnology Co., Ltd.

Tel: 17765276361
Country: CHINA
ProdList: 109
Advantage: 58

Shanghai Hongyu Biotechnology Co., Ltd.

Tel: 02158116080
Country: CHINA
ProdList: 147
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6655
Advantage: 58

Rhenbo (Shanghai) Biochemical Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6333
Advantage: 58

Suzhou Ruinuode Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 2090855807@qq.com
Country: CHINA
ProdList: 6249
Advantage: 58

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

Shanghai yiji industries Co., Ltd.

Tel: --
Fax: --
Email: yiji01@foxmail.com
Country: China
ProdList: 6021
Advantage: 50

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6151
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Shanghai Caiyou Industrial Co., Ltd.

Tel: --
Fax: --
Email: 15821073967@163.com
Country: CHINA
ProdList: 6748
Advantage: 58

Shanghai Jijin Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jijinhuaxue@sina.com
Country: CHINA
ProdList: 6606
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Less

View Lastest Price from 6',7'-DIHYDROXYBERGAMOTTIN manufacturers

Career Henan Chemical Co

Product: 6',7'-DIHYDROXYBERGAMOTTIN 145414-76-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-14

145414-76-2, 6',7'-DIHYDROXYBERGAMOTTINRelated Search:

4-ALLYLOXYCOUMARIN 6',7'-DIHYDROXYBERGAMOTTIN 4-ETHOXYCOUMARIN 1-BENZOFURAN-5-YLMETHANOL

4-[[(2E)-6,7-Dihydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one

6',7'-DIHYDROXYBERGAMOTTIN

6,7-dihydroxybergaMottin(DHB)

7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-6,7-dihydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-

145414-76-2

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Drug and Xenobiotic Metabolism

Multi-Drug Resistance and Drug Metabolism

Substrates, Inducers, Inhibitors