ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
- Product Name
- ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
- CAS No.
- 33458-26-3
- Chemical Name
- ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
- Synonyms
- 5118-36-5;EU-006731;NSC643910;SBB016167;NCI60_014903;Oprea1_330764;A0951/0044480;AURORA KA-3499;Maybridge1_006365;BUTTPARK 61\40-96
- CBNumber
- CB0767606
- Molecular Formula
- C14H16N2O2S
- Formula Weight
- 276.35
- MOL File
- 33458-26-3.mol
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE Property
- Melting point:
- 180
- Boiling point:
- 390.5±52.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- pka
- 11.33±0.70(Predicted)
- InChIKey
- QMFBVGUFEGVPNG-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- S170372
- Product name
- 6-ME-4-PH-2-THIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 061399
- Product name
- Ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- Packaging
- 500mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- CHM0029794
- Product name
- ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $624.07
- Updated
- 2021/12/16
- Product number
- CHM0029794
- Product name
- ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1176.29
- Updated
- 2021/12/16
- Product number
- ES01233
- Product name
- Ethyl6-Methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- Purity
- 95%
- Packaging
- 1gm:
- Price
- $60.09
- Updated
- 2021/12/16
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE Chemical Properties,Usage,Production
Uses
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process middle.
Synthesis
In a 10-mL round-bottom flask equipped with a condenser, a mixture of the aromatic aldehyde (1 mmol), ethyl acetoacetate (1 mmol), urea or thiourea (1.5 mmol) and [Dsbim]Cl (0.0376 g, 10 mol%) was stirred at 80 °C, and the resulting mixture was kept under continuous stirring for lengths of time as specified in Table 3, with the progress of the reaction was followed by TLC. After completion of the reaction, the mixture was cooled to room temperature, and 3 mL of water was added. The ionic liquid was dissolved in water and filtered for separation of the crude product. The separated product was washed twice with water (2 9 3 mL). For recycling the catalysts, after the solid products were thoroughly washed with water, the water containing the ionic liquid (IL is soluble in water) was evaporated under reduced pressure, and the ionic liquid was recovered and reused. The solid product was purified by a recrystallization procedure in ethanol. All of the desired product(s) were characterized by comparison of their physical data with those of known compounds. Entry: 13 Product: 4m; Yield: 90% Mp: 208-210°C; Lit. Mp: 205-206 [23]°C
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE manufacturers
- Product
- ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE 33458-26-3
- Price
- US $7.00/KG
- Min. Order
- 25KG
- Purity
- 99%
- Supply Ability
- 100TONS
- Release date
- 2018-07-23