4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID

Product Name: 4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID
CAS No.: 101439-76-3
Chemical Name: 4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID
Synonyms: BML-260;IFLAB-BB F0207-0150;4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid;Benzoic acid, 4-[4-oxo-5-(phenylmethylene)-2-thioxo-3-thiazolidinyl]-;4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID;4-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-3-yl}-benzoic acid
CBNumber: CB0770004
Molecular Formula: C17H11NO3S2
Formula Weight: 341.4
MOL File: 101439-76-3.mol

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4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID Property

solubility: DMSO: Soluble: =10 mg/ml
form: Yellow solid.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B535768
Product name: 4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoicAcid
Packaging: 50mg
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 135515
Product name: 4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
Purity: 95%+
Packaging: 1g
Price: $864
Updated: 2021/12/16

Matrix Scientific

Product number: 135515
Product name: 4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
Purity: 95%+
Packaging: 2.500g
Price: $1889
Updated: 2021/12/16

Matrix Scientific

Product number: 135515
Product name: 4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
Purity: 95%+
Packaging: 5g
Price: $2848
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000074
Product name: BML-260
Purity: 95.00%
Packaging: 10MG
Price: $199.5
Updated: 2021/12/16

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4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID Chemical Properties,Usage,Production

Uses

BML-260 is a potent inhibitor of dual-specific phosphatases JSP-1 and DUSP22. BML-260 can activate UCP1 and thermogenesis in adipocytes in a JSP-1-independent manner. The effect of BML-260 on adipocytes is partially achieved through the activation of CREB, STAT3, and PPAR signaling pathways. BML-260 can be used in the research of inflammatory and proliferative disorders associated with JNK signaling dysfunction as well as obesity[1][2].

References

[1] Williams D R, et al. Targeting phosphatase DUSP22 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression[J]. bioRxiv, 2024: 2024.04. 08.588643.
[2] Feng Z, et al. Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression[J]. Theranostics, 2019, 9(12): 3501. DOI:10.7150/thno.31951
[3] ESRA ALBAYRAK. BML-260 promotes the growth of cord blood and mobilized peripheral blood hematopoietic stem and progenitor cells with improved reconstitution ability[J]. Journal of cellular biochemistry, 2022, 123 12: 2009-2029. DOI: 10.1002/jcb.30324

4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID Suppliers

Canada 1 China 28 United Kingdom 1 United States 3 Global 33

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Cayman Chemical Company

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101439-76-3, 4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACIDRelated Search:

4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID AURORA 8767 AURORA 8768 AURORA 7611 4-[(5Z)-5-(4-BROMOBENZYLIDENE)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID AURORA 8675 SPECS AE-641/40198001 AURORA 9065 AURORA 8672 4-[(5Z)-5-(4-CHLOROBENZYLIDENE)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID 4-[(5Z)-5-(4-METHOXYBENZYLIDENE)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID AURORA 8674 AURORA 8673 4-[(5Z)-5-(4-HYDROXY-3-METHOXYBENZYLIDENE)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID AURORA 8770 4-((5Z)-5-[4-(DIMETHYLAMINO)BENZYLIDENE]-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL)BENZOIC ACID AURORA 8769 4-[(5Z)-5-(3,4-DIMETHOXYBENZYLIDENE)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID

BML-260

4-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-3-yl}-benzoic acid

4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid

IFLAB-BB F0207-0150

4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID

Benzoic acid, 4-[4-oxo-5-(phenylmethylene)-2-thioxo-3-thiazolidinyl]-

101439-76-3