4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID
- Product Name
- 4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID
- CAS No.
- 101439-76-3
- Chemical Name
- 4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID
- Synonyms
- BML-260;IFLAB-BB F0207-0150;4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid;Benzoic acid, 4-[4-oxo-5-(phenylmethylene)-2-thioxo-3-thiazolidinyl]-;4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID;4-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-3-yl}-benzoic acid
- CBNumber
- CB0770004
- Molecular Formula
- C17H11NO3S2
- Formula Weight
- 341.4
- MOL File
- 101439-76-3.mol
4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID Property
- solubility
- DMSO: Soluble: =10 mg/ml
- form
- Yellow solid.
N-Bromosuccinimide Price
- Product number
- B535768
- Product name
- 4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoicAcid
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- INB0000074
- Product name
- BML-260
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $199.5
- Updated
- 2021/12/16
- Product number
- 135515
- Product name
- 4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
- Purity
- 95%+
- Packaging
- 1g
- Price
- $864
- Updated
- 2021/12/16
- Product number
- 135515
- Product name
- 4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $1889
- Updated
- 2021/12/16
- Product number
- 135515
- Product name
- 4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
- Purity
- 95%+
- Packaging
- 5g
- Price
- $2848
- Updated
- 2021/12/16
4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID Chemical Properties,Usage,Production
Uses
BML-260 is a potent inhibitor of dual-specific phosphatases JSP-1 and DUSP22. BML-260 can activate UCP1 and thermogenesis in adipocytes in a JSP-1-independent manner. The effect of BML-260 on adipocytes is partially achieved through the activation of CREB, STAT3, and PPAR signaling pathways. BML-260 can be used in the research of inflammatory and proliferative disorders associated with JNK signaling dysfunction as well as obesity[1][2].
References
[1] Williams D R, et al. Targeting phosphatase DUSP22 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression[J]. bioRxiv, 2024: 2024.04. 08.588643.
[2] Feng Z, et al. Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression[J]. Theranostics, 2019, 9(12): 3501. DOI:10.7150/thno.31951
[3] ESRA ALBAYRAK. BML-260 promotes the growth of cord blood and mobilized peripheral blood hematopoietic stem and progenitor cells with improved reconstitution ability[J]. Journal of cellular biochemistry, 2022, 123 12: 2009-2029. DOI: 10.1002/jcb.30324
4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID Suppliers
- Tel
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- Fax
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- vasily.pinchuk@lifechemicals.com
- Country
- Canada
- ProdList
- 6706
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