METHYL ARACHIDONATE Property

Boiling point:

200-205℃ (1-2 Torr)

Density 

0.9168 g/cm3

refractive index 

1.4875 (589.3 nm 20℃)

storage temp. 

2-8°C

solubility 

chloroform: 50 mg/mL, clear, colorless

form 

Liquid

color 

Colourless

BRN 

1714445

Stability:

Light Sensitive

LogP

7.466 (est)

Safety

Hazard Codes 

F,Xn,N

Risk Statements 

19-67-65-50/53-38-11

Safety Statements 

9-16-29-33-60-61-62

RIDADR 

UN 3183 4.2/PG 3

WGK Germany 

3

F 

10-21-23

HazardClass 

4.2

PackingGroup 

I

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H336May cause drowsiness or dizziness

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P331Do NOT induce vomiting.

P501Dispose of contents/container to..…

METHYL ARACHIDONATE Chemical Properties,Usage,Production

Uses

Arachidonic acid is the keystone essential fatty acid at the origin of the arachidonic acid cascade. It is converted by cyclooxygenase, lipoxygenase, and epoxygenase enzymes into more than one hundred fifty different potent primary autacoid metabolites in species ranging from fungi to plants to mammals. Arachidonic acid is stored in tissue phospholipids in esterified form, where it comprises a small but critically controlled percentage of the polyunsaturated fatty acid pool. Arachidonic acid content is frequently measured by the saponification of the lipid fraction followed by methyl esterification and gas chromatographic analysis of the resulting FAME (fatty acid methyl ester) compounds. Arachidonic acid methyl ester can also be incorporated into dietary regimens or fed to cultured cells as a source of exogenous arachidonate.

Definition

ChEBI: A fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol.

Biochem/physiol Actions

Unlike most unsaturated fatty acid methyl esters, methyl arachidonate is a potent activator of protein kinase C at 5?50?μM. At the low end of the effective concentration range, the effect is due to cyclooxygenase products, while lipoxygenase products mediate the effect at higher concentrations.