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Arachidonic acid

Description References
Product Name
Arachidonic acid
CAS No.
506-32-1
Chemical Name
Arachidonic acid
Synonyms
ARA;FKHL7;FOXC1;20:4n-6;Vevodar;24891487;20:4(n-6);Arachidonic;Arachidonate;Immunocytophyt
CBNumber
CB8112259
Molecular Formula
C20H32O2
Formula Weight
304.47
MOL File
506-32-1.mol
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Arachidonic acid Property

Melting point:
-49 °C (lit.)
Boiling point:
169-171 °C/0.15 mmHg (lit.)
Density 
0.922 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4872(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
ethanol: ≥10 mg/mL
form 
oil
pka
4.75±0.10(Predicted)
color 
colorless to light yellow
Water Solubility 
PRACTICALLY INSOLUBLE
Merck 
14,765
Solvent
Ethanol under argon
Specific Activity
200-240 Ci/mmol
Concentration
1 mCi/ml
BRN 
1713889
InChIKey
YZXBAPSDXZZRGB-DOFZRALJSA-N
CAS DataBase Reference
506-32-1(CAS DataBase Reference)
NIST Chemistry Reference
Arachidonic acid(506-32-1)
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Safety

Risk Statements 
19
Safety Statements 
24/25-19
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol
WGK Germany 
3
RTECS 
CE6675000
8-10-23
HS Code 
29161900
Toxicity
dns-mus:mmr 10 mg/L CRNGDP 5,1123,84
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A-122
Product name
Arachidonic acid
Purity
1.0?mg/mL in ethanol, certified reference material, Cerilliant?
Packaging
1 mL
Price
$149
Updated
2021/12/16
Sigma-Aldrich
Product number
10931
Product name
Arachidonic acid
Purity
>95.0% (GC)
Packaging
250mg
Price
$150
Updated
2021/12/16
Sigma-Aldrich
Product number
10931
Product name
Arachidonic acid
Purity
>95.0% (GC)
Packaging
1g
Price
$374
Updated
2021/12/16
Sigma-Aldrich
Product number
SAB1412610
Product name
ANTI-FOXC1 antibody produced in mouse
Purity
clone 1E11, purified immunoglobulin, buffered aqueous solution
Packaging
100 μg
Price
$424
Updated
2021/12/16
Sigma-Aldrich
Product number
A3611
Product name
Arachidonic acid
Purity
from non-animal source, ≥98.5% (GC)
Packaging
10mg
Price
$72.4
Updated
2021/03/22
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Arachidonic acid Chemical Properties,Usage,Production

Description

Arachidonic acid belongs to a kind of polyunsaturated omega-6 fatty acid, which is highly biologically relevant. It is abundantly distributed in brain, muscles and liver. It is the precursor for all prostaglandins, thromboxanes, and leukotrienes. Most cellular arachidonic acid is esterified in the membrane phospholipids. It is an important second messenger of cellular signalling participating in the regulation of signaling enzymes including PLC-γ, PLC-δ, and PKC-α, -β, and -γ isoforms. In addition, arachidonic acid acts as key inflammatory intermediate as well as avasodilator. Generally, the body can synthesize the arachidonic acid through linoleic acid. However, upon linoleic acid deficiency, it is necessary to supplement arachidonic acid from the diets. Food sources of arachidonic acid include meat, eggs and some fishes. Alternatively, we can also have arachidonic acid supplements.

References

http://www.fitday.com/fitness-articles/nutrition/healthy-eating/what-is-arachidonic-acid.html
https://en.wikipedia.org/wiki/Arachidonic_acid
https://www.caymanchem.com/product/90010

Description

Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6). It is the counterpart to the saturated arachidic acid found in peanut oil, (L. arachis – peanut.).

Chemical Properties

In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end.
Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the term to all-cis-5,8,11,14- eicosatetraenoic acid.

Chemical Properties

liquid

Uses

An unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes

Uses

Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.

Uses

arachidonic acid is an ingredient with skin-smoothing, emollient, and healing properties. Arachidonic acid is an omega-6 essential fatty acid naturally occurring in the skin and considered critical for appropriate skin metabolism. It is a constituent of vitamin F.

Definition

ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.

Biological Activity

Endogenous free fatty acid released from phospholipids by phospholipase A 2 . Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.

Biochem/physiol Actions

Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .

Safety Profile

Poison by intravenous route.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits acridsmoke and irritating fumes.

Carcinogenicity

In vitro and in vivo studies indicate that inhibition of arachidonic acid metabolism inhibits the growth of malignant cells, including head and neck squamous cell carcinoma, and implicates arachadonic acid in facilitating the metastasis of these tumor cells. Arachidonic acid reaction with cyclooxygenase and lipoxygenases yield eicosanoids that can mediate prostate cancer proliferation and enhance both tumor vascularization and metastasis. Cytochrome P450 arachidonic acid epoxygenases promote cell proliferation and inhibit apoptosis in endothelial cells.

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Arachidonic acid Suppliers

Wuhan Zibo Rui Pharmaceutical Technology Co., Ltd.
Tel
027-63497939-
Email
1750669728@qq.com
Country
China
ProdList
147
Advantage
58
Shaanxi Pioneer Biotech Co., Ltd
Tel
029-86621125-
Email
sales@pioneerbiotech.com
Country
China
ProdList
499
Advantage
58
Hebei Zhentian Food Additives Co., Ltd.
Tel
0319-5925599- ;
Fax
0319 5925599
Email
13933732699@163.com;13933732699@163.com
Country
China
ProdList
922
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43431
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100-
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9636
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
Advantage
62
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View Lastest Price from Arachidonic acid manufacturers

Hebei Lingding Biological Technology Co., Ltd
Product
Arachidonic acid 506-32-1
Price
US $68.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-05-08
Hebei Guanlang Biotechnology Co., Ltd.
Product
Arachidonic acid 506-32-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2021-10-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Arachidonic acid 506-32-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

506-32-1, Arachidonic acidRelated Search:


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