MORPHOLIN-4-YL-ACETIC ACID
Uses- Product Name
- MORPHOLIN-4-YL-ACETIC ACID
- CAS No.
- 89531-58-8
- Chemical Name
- MORPHOLIN-4-YL-ACETIC ACID
- Synonyms
- 2-Morpholinoacetic acid hydrochloride;EOS-62303;AKOS BBS-00002525;RARECHEM AL BO 0383;TIMTEC-BB SBB010303;MORPHOLINOACETIC ACID;4-MORPHOLINOACETIC ACID;MORPHOLIN-4-YL-ACETIC ACID;4-MORPHOLINACETIC ACID HCL;4-Morpholineacetic acid HCL
- CBNumber
- CB0773287
- Molecular Formula
- C6H11NO3
- Formula Weight
- 145.16
- MOL File
- 89531-58-8.mol
MORPHOLIN-4-YL-ACETIC ACID Property
- Melting point:
- 160-161℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Powder
- color
- White
- Water Solubility
- Insoluble in water.
- InChI
- InChI=1S/C6H11NO3/c8-6(9)5-7-1-3-10-4-2-7/h1-5H2,(H,8,9)
- InChIKey
- ICGYBJNONRDZOP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CN1CCOCC1
- CAS DataBase Reference
- 89531-58-8
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36-36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29349990
N-Bromosuccinimide Price
- Product number
- ANV00112
- Product name
- 2-Morpholinoacetic acid hydrochloride
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $259
- Updated
- 2025/07/31
- Product number
- M2608
- Product name
- Morpholinoacetic Acid Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- M2608
- Product name
- Morpholinoacetic Acid Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $147
- Updated
- 2025/07/31
- Product number
- M722990
- Product name
- 4-MorpholineaceticAcidHydrochloride
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- M722990
- Product name
- 4-MorpholineaceticAcidHydrochloride
- Packaging
- 10g
- Price
- $445
- Updated
- 2021/12/16
MORPHOLIN-4-YL-ACETIC ACID Chemical Properties,Usage,Production
Uses
4-Morpholineacetic Acid Hydrochloride is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
Chemical Properties
White solid
Uses
4-Morpholineacetic Acid Hydrochloride is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
Synthesis
3235-82-3
89531-58-8
The general procedure for the synthesis of morpholine-4-acetic acid hydrochloride from ethyl 2-(4-morpholinyl)acetate is as follows: ethyl 4-morpholinoacetate (1.1 g, 6.3 mmol) was added to 3M hydrochloric acid solution (35 ml) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was stirred at room temperature for 24 hours. Subsequently, the reaction solution was concentrated under reduced pressure. The obtained residue was dissolved in methanol and concentrated again under reduced pressure. The final solid product obtained was suspended in ether, separated by filtration and dried under reduced pressure to give 1.05 g of morpholine-4-acetic acid hydrochloride in 91.7% yield. The product was characterized by NMR (DMSO-d6) with chemical shifts of 3.3 (s, 4H), 3.9 (s, 4H), 4.2 (s, 2H).
References
[1] Journal of the American Chemical Society, 2017, vol. 139, # 34, p. 11895 - 11902
[2] Patent: US6352993, 2002, B1. Location in patent: Page column 13
[3] Journal of Molecular Structure, 2001, vol. 560, # 1-3, p. 261 - 273
[4] Patent: US5521179, 1996, A
[5] Bioconjugate Chemistry, 2016, vol. 27, # 1, p. 226 - 237
MORPHOLIN-4-YL-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
MORPHOLIN-4-YL-ACETIC ACID Suppliers
- Tel
- --
- Fax
- --
- him@interchim.com
- Country
- France
- ProdList
- 2725
- Advantage
- 58
View Lastest Price from MORPHOLIN-4-YL-ACETIC ACID manufacturers
- Product
- MORPHOLIN-4-YL-ACETIC ACID 89531-58-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-21