Tryptophol

Product Name: Tryptophol
CAS No.: 526-55-6
Chemical Name: Tryptophol
Synonyms: 2-(1H-INDOL-3-YL)ETHAN-1-OL;3-(2-HYDROXYETHYL)INDOLE;INDOLE-3-ETHANOL;IEA;Indoleethanol;3-INDOLEETHANOL;B-3-INDOLYLETHANOL;BETA-3-INDOLYLETHANOL;DK803;NSC 3884
CBNumber: CB0782869
Molecular Formula: C10H11NO
Formula Weight: 161.2
MOL File: 526-55-6.mol

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Tryptophol Property

Melting point:: 56-59 °C(lit.)
Boiling point:: 174 °C (2.02527 mmHg)
Density: 1.0840 (rough estimate)
refractive index: 1.5200 (estimate)
Flash point:: 255 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: methanol: 0.1 g/mL, clear
pka: 15.16±0.10(Predicted)
form: Crystalline Mass, Crystals, Flakes or Powder
color: Off-white to brown
Water Solubility: 10 g/L (20 ºC)
Merck: 14,9798
BRN: 125553
InChIKey: MBBOMCVGYCRMEA-UHFFFAOYSA-N
LogP: 1.280 (est)
CAS DataBase Reference: 526-55-6(CAS DataBase Reference)
NIST Chemistry Reference: 1H-indole-3-ethanol(526-55-6)
EPA Substance Registry System: 1H-Indole-3-ethanol (526-55-6)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
RTECS: KL3685000
F: 8
Hazard Note: Irritant
TSCA: Yes
HS Code: 29339990
Toxicity: LD50 intraperitoneal in mouse: 351mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T90301
Product name: 3-(2-Hydroxyethyl)indole
Purity: 97%
Packaging: 5g
Price: $103
Updated: 2024/03/01

TCI Chemical

Product number: I0030
Product name: 3-Indoleethanol
Purity: >98.0%(GC)
Packaging: 1g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: I0030
Product name: 3-Indoleethanol
Purity: >98.0%(GC)
Packaging: 5g
Price: $101
Updated: 2024/03/01

Alfa Aesar

Product number: L02555
Product name: Tryptophol, 97%
Packaging: 1g
Price: $26.65
Updated: 2024/03/01

Alfa Aesar

Product number: L02555
Product name: Tryptophol, 97%
Packaging: 5g
Price: $86
Updated: 2024/03/01

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Tryptophol Chemical Properties,Usage,Production

Chemical Properties

3-(2-Hydroxyethyl)indole [526-55-6], tryptophol, C10H11NO, Mr 161.20, mp 59 ℃, bp 174 ℃, (2 kPa) forms colorless prisms or flakes that are readily soluble in methanol, ethanol, diethyl ether, chloroform, and acetone, soluble in benzene, and slightly soluble in water. It is produced by reacting methyl-1H-indole-3-acetate with lithium aluminum hydride, or through reduction of methyl-1H-indole-3-glyoxylate with sodium borohydride. The antihypertensive Indoramin is produced from tryptophol.

Uses

Tryptophol is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.

Uses

Reactant for preparation of:

Inhibitors of the C-terminal domain of RNA polymerase II and their antitumor activities
Anti-HIV-1 agents
Inhibitors of Protein-Protein Interactions
Partial agonists of the serotonin 5-HT1A receptor
Growth hormone secretagogues
Vascular endothelial growth factor (VEGF) inhibitors
A2B adenosine receptor ligands
Potential detoxification inhibitors of the crucifer phytoalexin brassinin
Inhibitors of interleukine 6
Dual binding site acetylcholinesterase inhibitors

Definition

ChEBI: An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2.

Synthesis Reference(s)

Canadian Journal of Chemistry, 42, p. 485, 1964 DOI: 10.1139/v64-070

Purification Methods

Crystallise it from diethyl ether/pet ether, *C6H6, *C6H6/pet ether. The picrate has m 100-101o (from *C6H6). [Beilstein 21 I 218, 21 II 49, 21 III/IV 788, 21/3 V 61.]

Tryptophol Preparation Products And Raw materials

Raw materials

Preparation Products

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Tryptophol Suppliers

Americas 1 Belgium 2 China 248 Europe 4 Germany 5 India 6 Japan 3 Slovakia 1 Switzerland 3 United Kingdom 12 United States 33 USA 1 Global 319

Apollo Scientific Ltd.

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Hawks Scientific Ltd

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MOLEKULA Ltd.

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CARBONE SCIENTIFIC CO.,LTD

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ProdList: 6666
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Eurolabs Limited

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ETA SCIENTIFIC Co.,Ltd

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UK GREEN SCIENTIFIC CO.,LIMITED

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ProdList: 6098
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Fluorochem Ltd.

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VWR International

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Zerenex Molecular Limited

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Sequoia Research Products Ltd.

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MDA Chemicals Ltd.

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ProdList: 1961
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View Lastest Price from Tryptophol manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Tryptophol 526-55-6
Price: US $25.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2024-11-20

Hebei Yanxi Chemical Co., Ltd.

Product: Tryptophol 526-55-6
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-09-21

Hebei Chuanghai Biotechnology Co,.LTD

Product: Tryptophol 526-55-6
Price: US $5.70/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-09

526-55-6, TryptopholRelated Search:

Indole-3-acetic acid Oxindole Hydroxyethyl starch Ethanol Indole-3-butyric acid Indole Methyl 2-hydroxyethyl cellulose 2-(2-Aminoethylamino)ethanol PIPERACETAZINE (250 MG) Hydroxyethyl Cellulose Indometacin Sodium isethionate 2-(METHYLSULFONYL)ETHANOL TRYPTAMINE HYDROCHLORIDE Tryptamine 5-BENZYLOXYINDOLE-3-ACETIC ACID 5-METHYLINDOLE-3-ACETIC ACID METHYL 3-INDOLYLACETATE

INDOLE-3-ETHANOL

B-3-INDOLEETHANOL

B-3-INDOLYLETHANOL

BETA-3-INDOLYLETHANOL

3-(BETA-HYDROXYETHYL)INDOLE

3-INDOLEETHANOL

2-(1H-INDOL-3-YL)ETHAN-1-OL

2-(1H-INDOL-3-YL)-ETHANOL

2-(3-INDOLE)ETHANOL

3-(2-HYDROXYETHYL)INDOLE

RARECHEM AH BS 0132

TIMTEC-BB SBB003950

TRYPTOTHOL

TRYPTOPHOL

'TRYPTOPHOL'

1H-Indole-3-ethanol

2-(3-Indolylethanol

3-indolyl-ethano

3-Indolylethanol

3-(2-Hydroxyethyl)indole 97%

Color alcohol

NSC 3884

3-(2-Hydroxyethyl)indole Vetec(TM) reagent grade, 97%

3-Indoleethanol 3-(2-Hydroxyethyl)indole beta-3-Indolylethanol 2-(1H-Indol-3-yl)ethan-1-ol

beta-(3-Indole)ethanol

dl-Tryptophanol

Ethanol, 2-indol-3-yl-

Ethanol, 3-indolyl-

IEA

Indoleethanol

3-β-hydroxyethyl in-dole

β-indolylethylalcohol

3-(2-Hydroxyethyl)indole~2-(3-Indolyl)ethanol

beta-indol-3-ylethanol

Tryptophol (Indole-3-ethanol)

TRYPTOPHOL ULTRA-PURE 99.5%

Tryptophol,97%

3-(2-HYDROXYETHYL)INDOLE (TRYPTOPHOL)

Tryptophol, 3-Indoleethanol

TRYPTOPHOL(IEt)

3-(2-Hydroxyethyl)-1H-indole

Tryptophol, 2-(1H-Indol-3-yl)ethan-1-ol

Tryptophol, 97% 5GR

Indole-3-ethanol (Tryptophol),beta-3-Indolylethanol

3-Indoleethanol&gt

ryptophol

Tryptopho

?-indol-3-ylethanol

Tryptophol (6CI)

DK803

3-Indoleethanol , Tryptophol

526-55-6

Indoles

Simple Indoles

Heterocyclic Building Blocks

Building Blocks

Heterocyclic Compounds

Indoles