(Rac)-Benpyrine

Product Name: (Rac)-Benpyrine
CAS No.: 1333714-43-4
Chemical Name: (Rac)-Benpyrine
Synonyms: (Rac)-Benpyrine;Benpyrine racemate;(Rac)-Benpyrine, 10 mM in DMSO;4-((9H-Purin-6-yl)amino)-1-benzylpyrrolidin-2-one;2-Pyrrolidinone, 1-(phenylmethyl)-4-(9H-purin-6-ylamino)-;autoimmune,Inhibitor,anti-inflammatory,(Rac) Benpyrine,(Rac)-Benpyrine,Tumor Necrosis Factor Receptor,IFN-γ,IL-1β,(Rac)Benpyrine,inhibit,TNF Receptor,IL-6,NF-κB,TNFR,TNF-α,IL-10
CBNumber: CB08057640
Molecular Formula: C16H16N6O
Formula Weight: 308.34
MOL File: 1333714-43-4.mol

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(Rac)-Benpyrine Property

Boiling point:: 699.1±55.0 °C(Predicted)
Density: 1.456±0.06 g/cm3(Predicted)
solubility: DMF: 1 mg/ml
form: A solid
pka: 10.01±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC40738
Product name: (Rac)-Benpyrine
Purity: >98%
Packaging: 100mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC40738
Product name: (Rac)-Benpyrine
Purity: >98%
Packaging: 250mg
Price: $900
Updated: 2021/12/16

DC Chemicals

Product number: DC40738
Product name: (Rac)-Benpyrine
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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(Rac)-Benpyrine Chemical Properties,Usage,Production

Uses

(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].

in vivo

(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction^[1].

Animal Model:	Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant^[1]
Dosage:	25 mg/kg, 50 mg/kg
Administration:	Oral gavage; daily; for 3 weeks
Result:	The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.

References

[1] Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A.

(Rac)-Benpyrine Preparation Products And Raw materials

Raw materials

Preparation Products

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(Rac)-Benpyrine Suppliers

China 35 United States 6 Global 41

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1333714-43-4, (Rac)-BenpyrineRelated Search:

(Rac)-Benpyrine

4-((9H-Purin-6-yl)amino)-1-benzylpyrrolidin-2-one

autoimmune,Inhibitor,anti-inflammatory,(Rac) Benpyrine,(Rac)-Benpyrine,Tumor Necrosis Factor Receptor,IFN-γ,IL-1β,(Rac)Benpyrine,inhibit,TNF Receptor,IL-6,NF-κB,TNFR,TNF-α,IL-10

2-Pyrrolidinone, 1-(phenylmethyl)-4-(9H-purin-6-ylamino)-

Benpyrine racemate

(Rac)-Benpyrine, 10 mM in DMSO

1333714-43-4