(Rac)-Benpyrine
- Product Name
- (Rac)-Benpyrine
- CAS No.
- 1333714-43-4
- Chemical Name
- (Rac)-Benpyrine
- Synonyms
- (Rac)-Benpyrine;Benpyrine racemate;(Rac)-Benpyrine, 10 mM in DMSO;4-((9H-Purin-6-yl)amino)-1-benzylpyrrolidin-2-one;2-Pyrrolidinone, 1-(phenylmethyl)-4-(9H-purin-6-ylamino)-;autoimmune,Inhibitor,anti-inflammatory,(Rac) Benpyrine,(Rac)-Benpyrine,Tumor Necrosis Factor Receptor,IFN-γ,IL-1β,(Rac)Benpyrine,inhibit,TNF Receptor,IL-6,NF-κB,TNFR,TNF-α,IL-10
- CBNumber
- CB08057640
- Molecular Formula
- C16H16N6O
- Formula Weight
- 308.34
- MOL File
- 1333714-43-4.mol
(Rac)-Benpyrine Property
- Boiling point:
- 699.1±55.0 °C(Predicted)
- Density
- 1.456±0.06 g/cm3(Predicted)
- solubility
- DMF: 1 mg/ml
- form
- A solid
- pka
- 10.01±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- DC40738
- Product name
- (Rac)-Benpyrine
- Purity
- >98%
- Packaging
- 100mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- DC40738
- Product name
- (Rac)-Benpyrine
- Purity
- >98%
- Packaging
- 250mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- DC40738
- Product name
- (Rac)-Benpyrine
- Purity
- >98%
- Packaging
- 1g
- Price
- $1800
- Updated
- 2021/12/16
(Rac)-Benpyrine Chemical Properties,Usage,Production
Uses
(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].
in vivo
(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1].
| Animal Model: | Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1] |
| Dosage: | 25 mg/kg, 50 mg/kg |
| Administration: | Oral gavage; daily; for 3 weeks |
| Result: | The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased. |
References
[1] Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A.
(Rac)-Benpyrine Preparation Products And Raw materials
Raw materials
Preparation Products
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