Blosozumab

Product Name: Blosozumab
CAS No.: 1132758-87-2
Chemical Name: Blosozumab
Synonyms: Blosozumab;Blosozumab (anti-SOST);Research Grade Blosozumab;Research Grade Blosozumab(DHJ48702)
CBNumber: CB08080837
Formula Weight: 0
MOL File: Mol file

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Blosozumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Blosozumab Chemical Properties,Usage,Production

Uses

Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2].

in vivo

Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats^[1].

Animal Model:	Sprague-Dawley rats ^[2]
Dosage:	1, 10, and 100 mg/kg
Administration:	Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study)
Result:	Observed the bone anabolic effects. Showed significant bleeding and morbidity at 100 mg/kg. Decreases in the numbers of platelets. Increased number of bone marrow megakaryocytes at 100 mg/kg.

References

[1] Robert R Recker, et al. A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density. J Bone Miner Res. 2015 Feb;30(2):216-24. DOI:10.1002/jbmr.2351
[2] Daniel G Rudmann, et al. Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci. 2012 Feb;125(2):586-94. DOI:10.1093/toxsci/kfr318

Blosozumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Blosozumab Suppliers

China 16 United States 2 Global 18

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Blosozumab

Research Grade Blosozumab(DHJ48702)

Blosozumab (anti-SOST)

Research Grade Blosozumab

1132758-87-2