ChemicalBook > CAS DataBase List > Ocaratuzumab
Ocaratuzumab
- Product Name
- Ocaratuzumab
- CAS No.
- 1169956-08-4
- Chemical Name
- Ocaratuzumab
- Synonyms
- Ocaratuzumab;Ocaratuzumab (anti-CD20);Research Grade Ocaratuzumab
- CBNumber
- CB08080862
- Formula Weight
- 0
- MOL File
- Mol file
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Ocaratuzumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Ocaratuzumab Chemical Properties,Usage,Production
Uses
Ocaratuzumab (AME 133v) is an Fc-engineered humanized IgG1 anti-CD20 monoclonal antibody, with a Kd of ~100 pM. Ocaratuzumab exhibits more effective antibody-dependent cell-mediated cytotoxicity (ADCC)[1][2].
References
[1] Forero-Torres A, et, al. Results of a phase 1 study of AME-133v (LY2469298), an Fc-engineered humanized monoclonal anti-CD20 antibody, in FcγRIIIa-genotyped patients with previously treated follicular lymphoma. Clin Cancer Res. 2012 Mar 1;18(5):1395-403. DOI:10.1158/1078-0432.CCR-11-0850
[2] Cheney CM, et, al. Ocaratuzumab, an Fc-engineered antibody demonstrates enhanced antibody-dependent cell-mediated cytotoxicity in chronic lymphocytic leukemia. MAbs. 2014 May-Jun;6(3):749-55. DOI:10.4161/mabs.28282
Ocaratuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
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Ocaratuzumab Suppliers
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