ChemicalBook > CAS DataBase List > 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-

Product Name
4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
CAS No.
1453099-83-6
Chemical Name
4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
Synonyms
TAS-119;TAS2104;TAS 2104;VIC-1911;TAS-2104;VIC-1911 (TAS-119);TAS-119, 10 mM in DMSO;TAS119|||TAS2104|||TAS 2104|||TAS-2104|||TAS 119;4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
CBNumber
CB08101561
Molecular Formula
C23H22Cl2FN5O3
Formula Weight
506.36
MOL File
1453099-83-6.mol
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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Property

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (98.74 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
25mg
Price
$1350
Updated
2021/12/16
ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
50mg
Price
$2200
Updated
2021/12/16
ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
100mg
Price
$3400
Updated
2021/12/16
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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Chemical Properties,Usage,Production

Uses

TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites[1].

in vivo

TAS-119 (5-30 mg/kg; oral administration; twice daily on day 1 and everyday on day 2) treatment induces phosphorylated histone H3 (pHH3) in nude rats with the HeLa-luc xenografts[1].

Animal Model:Nude rats injected with HeLa-luc cells[1]
Dosage:5 mg/kg, 10 mg/kg, and 30 mg/kg
Administration:Oral administration; twice daily on day 1 and everyday on day 2
Result:Induced pHH3 at all doses in nude rats with the HeLa-luc xenografts.

IC 50

Aurora A: 1 nM (IC50); Aurora B: 95 nM (IC50)

References

[1] Hiroshi Sootome, et al. Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design. Mol Cancer Ther. 2020 Oct;19(10):1981-1991. DOI:10.1158/1535-7163.MCT-20-0036

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Suppliers

China 33 United States 1 Global 34
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185;
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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Shanghai Chaolan Chemical Technology Center
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ShangHai ChuanQian Chemcial Technique Centre
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Jinan Jiuli Biotechnology Co. , Ltd.
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1453099-83-6, 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-Related Search:


  • 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
  • TAS-119
  • TAS 2104
  • TAS2104
  • TAS-2104
  • VIC-1911 (TAS-119)
  • TAS119|||TAS2104|||TAS 2104|||TAS-2104|||TAS 119
  • TAS-119, 10 mM in DMSO
  • VIC-1911
  • 1453099-83-6
  • C23H22Cl2FN5O3
  • APIs