(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE

Product Name: (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE
CAS No.: 204512-95-8
Chemical Name: (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE
Synonyms: (S)-Tetrahydrofuran-;(3S)-tetrahydrofuran-3-amine;(S)-3-AMinotetrahydrofuran, HCl;(3S)-3-oxolanamine hydrochloride;(3S)-Tetrahydro-3-furanaMine HCl;(3S)-oxolan-3-aMine hydrochloride;[(3S)-Oxolan-3-yl]amine hydrochloride;(S)4-Aminotetrahydrofuran hydrochloride;(S)-3-aminotetrahydrofuran hydrochloride;(S)-Tetrahydro-3-furylamine hydrochloride
CBNumber: CB0813374
Molecular Formula: C4H10ClNO
Formula Weight: 123.58
MOL File: 204512-95-8.mol

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(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid
Appearance: White to off-white Crystal
optical activity: Consistent with structure
InChI: InChI=1/C4H9NO.ClH/c5-4-1-2-6-3-4;/h4H,1-3,5H2;1H/t4-;/s3
InChIKey: MHOVLDXJDIEEMJ-WCCKRBBISA-N
SMILES: N[C@@H]1COCC1.Cl |&1:1,r|
CAS DataBase Reference: 204512-95-8

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: A630755
Product name: (S)-3-AminotetrahydrofuranHydrochloride
Packaging: 5g
Price: $565
Updated: 2021/12/16

Activate Scientific

Product number: AS18386-B
Product name: (S)-3-Aminotetrahydrofuran HCl
Purity: 96% ee
Packaging: 1g
Price: $32
Updated: 2021/12/16

Matrix Scientific

Product number: 073909
Product name: (S)-3-Aminotetrahydrofuran hydrochloride
Purity: 95+%
Packaging: 1g
Price: $45
Updated: 2021/12/16

BroadPharm

Product number: BP-11345
Product name: (S)-tetrahydrofuran-3-amine
Purity: 96%
Packaging: 250mg
Price: $110
Updated: 2021/12/16

Activate Scientific

Product number: AS18386-B
Product name: (S)-3-Aminotetrahydrofuran HCl
Purity: 96% ee
Packaging: 5G
Price: $132
Updated: 2021/12/16

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(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

(S)-3-Aminotetrahydrofuran Hydrochloride is an intermediate used to prepare 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors.

Synthesis

152495-79-9

204512-95-8

(S)-3-Benzoylamino tetrahydrofuran (20.0 g, 0.105 mol) was dissolved in ethanol (40 mL), followed by addition of an aqueous sodium hydroxide solution (25 g sodium hydroxide dissolved in 120 mL of water). The reaction mixture was heated to reflux for 9-10 h. The reaction was monitored by TLC until complete disappearance of the starting material. After completion of the reaction, the mixture was cooled to room temperature and acidified with dilute hydrochloric acid. The precipitated benzoic acid was removed by filtration and the aqueous phase was washed with dichloromethane and concentrated to give a crude product containing the salt. Isopropanol was added to the crude product and stirred at room temperature for 1 hour. The salt was removed by filtration and the filtrate was concentrated to dryness to give a paste. The paste was co-stirred with isopropanol to promote crystallization and subsequently filtered, washed with cold isopropanol and dried under vacuum. Yield: 11 g (85% of theoretical yield); Melting point: 165-170 °C; [α]27D = -10.2 (c 1 , methanol); 1H NMR (300 MHz, CDCl3) δ (ppm): 3.80-4.11 (m, 5H), 2.37-2.5 (m, 1H), 2.01-2.09 (m, 1H); 13C NMR ( 300 MHz, CDCl3) δ (ppm): 70.49, 66.82, 51.21, 30.01; Elemental analysis (C4H10ClNO, FW 123.5813) Calculated values: C, 38.88; H, 8.16; N, 11.33. Measured values: C, 38.97; H, 7.86; N, 11.39. By transforming the product converted to its benzoyl derivative and analyzed by chiral HPLC using a Chiralpak AD-H column to determine the enantiomeric excess (Figure 2).

References

[1] Tetrahedron Asymmetry, 2013, vol. 24, # 11, p. 663 - 668
[2] Patent: US2008/255377, 2008, A1. Location in patent: Page/Page column 3

(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE Suppliers

China 140 India 6 United Arab Emirates 1 United Kingdom 1 United States 11 Global 159

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View Lastest Price from (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (3S)-oxolan-3-amine,hydrochloride 204512-95-8
Price: US $9.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (S)-tetrahydrofuran-3-amine hydrochloride 204512-95-8
Price: US $9.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (S)-tetrahydrofuran-3-amine hydrochloride 204512-95-8
Price: US $9.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-24

204512-95-8, (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDERelated Search:

PUROMYCIN DIHYDROCHLORIDE 3-Aminotubercidindichloroplatinum(II) (1S,4S)-2-OXA-5-AZABICYCLO[2.2.1]HEPTANE HCL PUROMYCIN DIHYDROCHLORIDE DIHYDRATE PUROMYCIN DIHYDROCHLORIDE PUROMYCIN DIHYDROCHLORIDE, [8-3H(N)]- L-Homoserine lactone hydrochloride (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE

(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE

(S)-3-aminotetrahydrofuran hydrochloride

(3S)-Tetrahydrofuran-3-aMine hydrochloride

(S)-3-AMinotetrahydrofuran, HCl

(3S)-oxolan-3-aMine hydrochloride

(S)-Tetrahydro-furan-3-ylamine hydrochloride

(S)-Tetrahydro-3-furylamine hydrochloride

[(3S)-Oxolan-3-yl]amine hydrochloride

(3S)-Tetrahydro-3-furanaMine HCl

(3S)-3-oxolanamine hydrochloride

(S)-(+)-3-Aminotetrahydrofuranhydrochloride,95%

3-Furanamine, tetrahydro-, hydrochloride (1:1), (3S)-

(3S)-tetrahydrofuran-3-amine

(S)-Tetrahydrofuran-

(S)4-Aminotetrahydrofuran hydrochloride

204512-95-8