2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Property

Boiling point:

601.2±55.0 °C(Predicted)

Density 

1.876±0.06 g/cm3(Predicted)

solubility 

DMSO : 25 mg/mL (67.54 mM; Need ultrasonic)

pka

10.67±0.40(Predicted)

form 

Solid

color 

Light yellow to yellow

Hazard and Precautionary Statements (GHS)

2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Usage,Production

Biological Activity

Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1]. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

References

[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.