N2-METHYL-PYRIDINE-2,3-DIAMINE
- Product Name
- N2-METHYL-PYRIDINE-2,3-DIAMINE
- CAS No.
- 5028-20-6
- Chemical Name
- N2-METHYL-PYRIDINE-2,3-DIAMINE
- Synonyms
- IFLAB-BB F2113-0168;2-N-METHYLPYRIDINE-2,3-DIAMINE;N2-METHYL-PYRIDINE-2,3-DIAMINE;2,3-Pyridinediamine, N2-methyl-;N~2~-Methyl-2,3-pyridinediaMine (SALTDATA: FREE)
- CBNumber
- CB0825265
- Molecular Formula
- C6H9N3
- Formula Weight
- 123.16
- MOL File
- 5028-20-6.mol
N2-METHYL-PYRIDINE-2,3-DIAMINE Property
- Melting point:
- 100-101 °C
- Boiling point:
- 145 °C
- Density
- 1.179±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 7.04±0.10(Predicted)
- Appearance
- Brown to purple Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B496308
- Product name
- N2-Methylpyridine-2,3-diamine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B496308
- Product name
- N2-Methylpyridine-2,3-diamine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 052701
- Product name
- N2-Methyl-2,3-pyridinediamine
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 6884AB
- Product name
- N2-Methylpyridine-2,3-diamine
- Packaging
- 1g
- Price
- $307
- Updated
- 2021/12/16
- Product number
- CS-0046883
- Product name
- N2-Methylpyridine-2,3-diamine
- Packaging
- 1g
- Price
- $328
- Updated
- 2021/12/16
N2-METHYL-PYRIDINE-2,3-DIAMINE Chemical Properties,Usage,Production
Uses
N2-Methylpyridine-2,3-diamine is a useful reagent in synthesis of imidazopyridines, which show tuberculostatic activity.
Synthesis
4093-88-3
5028-20-6
General procedure for the synthesis of N2-methyl-2,3-pyridinediamine from N-methyl-3-nitropyridin-2-amine: N-methyl-3-nitropyridin-2-amine (58.14 g, 0.38 mol) was dissolved in 1,2-dimethoxyethane (400 mL) under vigorous stirring. Activated carbon (2.9 g) was added to the resulting solution, refluxed for 2 hours and left at room temperature overnight. After displacing the reaction system with dry nitrogen, 10% Pd/C catalyst (1.75 g) was added. The mixture was heated to 40 °C and hydrazine monohydrate (54 mL, 1.08 mol) was slowly added dropwise over a period of 2 hours. After dropwise addition, the reaction mixture was refluxed for 2 h. After cooling, the reaction mixture was filtered through a column of diatomaceous earth (upper layer, 3 cm) and silica gel (lower layer, 5 cm, 13 cm diameter) to remove the catalyst. The filtrate layer was washed with 1,2-dimethoxyethane (300 mL). The filtrate was concentrated under reduced pressure to afford N2-methyl-2,3-pyridinediamine in 98% yield (46.2 g) as a brown crystalline solid. The product could be used directly in the subsequent reaction without further purification.
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 57, p. 14173 - 14176
[2] Open Medicinal Chemistry Journal, 2018, vol. 12, # 1, p. 74 - 83
[3] Patent: WO2008/12622, 2008, A2. Location in patent: Page/Page column 57
[4] Patent: CN106831776, 2017, A. Location in patent: Paragraph 0100; 0101; 0102
[5] Patent: WO2012/121936, 2012, A2. Location in patent: Page/Page column 93-94
N2-METHYL-PYRIDINE-2,3-DIAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N2-METHYL-PYRIDINE-2,3-DIAMINE manufacturers
- Product
- N2-METHYL-PYRIDINE-2,3-DIAMINE 5028-20-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95.0-99.8%
- Supply Ability
- 1KG;5KG 10KG; 100KG
- Release date
- 2019-09-02