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METHYLERGONOVINE

Product Name
METHYLERGONOVINE
CAS No.
113-42-8
Chemical Name
METHYLERGONOVINE
Synonyms
Partergin;Prestwick_727;Methylergosine;Methylergometrin;Methylergobrevin;Methylergobasine;METHYLERGONOVINE;methylergometrine;Methylergonovine-D3;METHYLERGONOVINE USP/EP/BP
CBNumber
CB0833158
Molecular Formula
C20H25N3O2
Formula Weight
339.44
MOL File
113-42-8.mol
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METHYLERGONOVINE Property

Melting point:
172-173℃ (decomposition)
alpha 
D20 -45° (c = 0.4 in pyridine)
Boiling point:
475.4°C (rough estimate)
Density 
1.1492 (rough estimate)
refractive index 
1.6650 (estimate)
storage temp. 
Desiccate at RT
pka
pKa 6.65± 0.03(H2O,t =24,I<0.01)(Approximate)
color 
Prisms from MeOH/Me2CO
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Safety

Hazardous Substances Data
113-42-8(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 93 mg/kg 27ZIAQ -,163,73
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0006820
Product name
METHYLERGONOVINE
Purity
95.00%
Packaging
50MG
Price
$648.83
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006820
Product name
METHYLERGONOVINE
Purity
95.00%
Packaging
250MG
Price
$976.27
Updated
2021/12/16
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METHYLERGONOVINE Chemical Properties,Usage,Production

Chemical Properties

Shiny crystals; melts at 172°C (341.6°F);moderately soluble in water, dissolves readilyin alcohol and acetone.

Originator

Methergine,Sandoz,US,1948

Uses

Methylergonovine is a drug currently used as a smooth muscle constrictor during postpartum hemorrhage, as an inhibitor of the inflammasome complex in ASC-mediated procaspase-1 activation screening.

Uses

This compound is a homologue of ergonovine.It is used in the treatment of postpartumhemorrhage.

Uses

Oxytocic.

Definition

ChEBI: (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide is an ergoline alkaloid.

Manufacturing Process

To a freshly prepared solution of 2 parts of d-isolysergic acid azide in 300 parts of either is added an ethereal solution of 2 parts of d-2-aminobutanol-1 and the mixture is left to stand at room temperature during 12 hours. The yellowish clear solution is then washed several times with some water, dried over sodium sulfate and the ether evaporated in vacuo. The crystallized residue is treated with a small quantity of acetone and filtered. Yield: 2.2 parts of d-isolysergic acid-d-1-hydroxybutylamide-2. On recrystallization from some hot methanol the new compound is obtained in form of beautiful polygonal crystals that melt with some decomposition at 192° to 194°C (corr.).
1 part of the iso-compound is then dissolved in 10 parts of absolute ethanol and an alcoholic potassium hydroxide solution is added thereto. The mixture is left to stand at room temperature during 45 minutes. After this time equilibrium is reached between lysergic acid and the isolysergic acid forms, which can be checked by determination of the constancy of the optical rotation of the solution. When this point is reached, potassium hydroxide is transformed into potassium carbonate by bubbling through the solution a stream of carbon dioxide; the thick crystal paste of potassium carbonate is then diluted with 50 parts of ether, filtered and washed again with 50 parts of ether.
The alcoholic ethereal filtrate is then dried over calcined potassium carbonate and the solution evaporated, whereby 0.9 to 1 part of a mixture of d-lysergic acid-d-1-hydroxybutylamide-2 and of d-isolysergic acid-d-1- hydroxybutylamide-2 is obtained. In order to separate the isomers, the residue is dissolved in 15 parts of hot chloroform and filtered from the small quantity of inorganic salt, whereby on cooling down, the difficultly soluble chloroform compound of d-lysergic acid-d-1-hydroxybutylamide-2 crystallizes out. Yield: 0.4 part. This compound can be recrystallized from hot benzene, whereby crystals melting with some decomposition at 172°C (corr.) are obtained. It may then be reacted with maleic acid to give the maleate.

brand name

Methergine(Novartis).

Therapeutic Function

Oxytocic

Health Hazard

The toxic effects due to methylergonovine inhumans include nausea, vomiting, dizziness,and hypertension. The oral and intravenousLD50 values in mice are 187 and 85 mg/kg,respectively.

Biological Activity

Active metabolite of methysergide ; uterotonic agent and oxytocic.

Safety Profile

Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.

METHYLERGONOVINE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYLERGONOVINE Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai Zhibang Biological Medicine Co., LTD
Tel
021-54285032 18116461626
Fax
021-54285032
Email
25493162@qq.com
Country
China
ProdList
142
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10386
Advantage
58
Hunan chemfish Scientific co.,ltd
Tel
0731-85567275 19186994443
Email
sales@chemfish.com
Country
China
ProdList
4889
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30239
Advantage
58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD
Tel
+86-0731-85567275 18932438858
Fax
QQ:3554193828
Email
sales05@chemfish.com
Country
China
ProdList
8301
Advantage
58
Nanjing wangzhixing Pharmaceutical Technology Co., Ltd
Tel
15850510341
Fax
025-85722793
Email
shiqingran@wzxchem.com
Country
China
ProdList
3746
Advantage
58
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View Lastest Price from METHYLERGONOVINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
METHYLERGONOVINE 113-42-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26

113-42-8, METHYLERGONOVINERelated Search:


  • 9,10-Didehydo-N-[(S)-1-(hydroxymethyl)propyl]-6-methylergoline-8β-carboxamide
  • Methylergobasine
  • Methylergobrevin
  • Methylergometrin
  • Prestwick_727
  • [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamidemaleate
  • N-[alpha-(Hydroxymethyl)propyl]-D-lysergamide
  • Partergin
  • METHYLERGONOVINE
  • methylergometrine
  • Ergoline-8-carboxaMide,9,10-didehydro-N-[(1S)-1-(hydroxyMethyl)propyl]-6-Methyl-, (8b)-
  • Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8β)-
  • Methylergonovine (Methylergometrine)
  • METHYLERGONOVINE USP/EP/BP
  • Methylergonovine-D3
  • Methylergosine
  • Methylergometrine Impurity
  • 113-42-8
  • 104305-93-9
  • API