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Methylergonovine maleate salt

Product Name
Methylergonovine maleate salt
CAS No.
57432-61-8
Chemical Name
Methylergonovine maleate salt
Synonyms
Erezin;Derganin;Partan M;erezingen;Metenarin;Methergin;methergine;Ryegonovin;Basofortina;Spametrin F
CBNumber
CB6343310
Molecular Formula
C24H29N3O6
Formula Weight
455.51
MOL File
57432-61-8.mol
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Methylergonovine maleate salt Property

Melting point:
1720C (dec)
Boiling point:
561.98°C (rough estimate)
Density 
1.2744 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
-20°C Freezer
solubility 
H2O: 25 mg/mL
form 
Solid
color 
white
Water Solubility 
Soluble to 25 mM in water
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-62
Safety Statements 
36/37/39-45
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
3
RTECS 
KE5500000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2939690000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1430000
Product name
Methylergonovine maleate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$261.6
Updated
2024/03/01
Tocris
Product number
0549
Product name
Methylergometrinemaleate
Purity
≥98%(HPLC)
Packaging
250
Price
$473
Updated
2021/12/16
Tocris
Product number
0549
Product name
Methylergometrinemaleate
Purity
≥98%(HPLC)
Packaging
50
Price
$116
Updated
2021/12/16
Usbiological
Product number
255800
Product name
Methylergometrine maleate
Packaging
50mg
Price
$366
Updated
2021/12/16
Usbiological
Product number
016814
Product name
Methyl Ergonovine Maleate Salt
Packaging
5mg
Price
$460
Updated
2021/12/16
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Methylergonovine maleate salt Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Methergine,Sandoz,US,1948

Uses

A metabolite of Methysergide. Semisynthetic ergot alkaloid. Oxytocic

Definition

ChEBI: Methylergonovine Maleate is an ergoline alkaloid. It has a role as a geroprotector.

Manufacturing Process

To a freshly prepared solution of 2 parts of d-isolysergic acid azide in 300 parts of either is added an ethereal solution of 2 parts of d-2-aminobutanol-1 and the mixture is left to stand at room temperature during 12 hours. The yellowish clear solution is then washed several times with some water, dried over sodium sulfate and the ether evaporated in vacuo. The crystallized residue is treated with a small quantity of acetone and filtered. Yield: 2.2 parts of d-isolysergic acid-d-1-hydroxybutylamide-2. On recrystallization from some hot methanol the new compound is obtained in form of beautiful polygonal crystals that melt with some decomposition at 192° to 194°C (corr.).
1 part of the iso-compound is then dissolved in 10 parts of absolute ethanol and an alcoholic potassium hydroxide solution is added thereto. The mixture is left to stand at room temperature during 45 minutes. After this time equilibrium is reached between lysergic acid and the isolysergic acid forms, which can be checked by determination of the constancy of the optical rotation of the solution. When this point is reached, potassium hydroxide is transformed into potassium carbonate by bubbling through the solution a stream of carbon dioxide; the thick crystal paste of potassium carbonate is then diluted with 50 parts of ether, filtered and washed again with 50 parts of ether.
The alcoholic ethereal filtrate is then dried over calcined potassium carbonate and the solution evaporated, whereby 0.9 to 1 part of a mixture of d-lysergic acid-d-1-hydroxybutylamide-2 and of d-isolysergic acid-d-1- hydroxybutylamide-2 is obtained. In order to separate the isomers, the residue is dissolved in 15 parts of hot chloroform and filtered from the small quantity of inorganic salt, whereby on cooling down, the difficultly soluble chloroform compound of d-lysergic acid-d-1-hydroxybutylamide-2 crystallizes out. Yield: 0.4 part. This compound can be recrystallized from hot benzene, whereby crystals melting with some decomposition at 172°C (corr.) are obtained. It may then be reacted with maleic acid to give the maleate.

brand name

Methergine(Novartis).

Therapeutic Function

Oxytocic

storage

Desiccate at RT

Methylergonovine maleate salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Methylergonovine maleate salt Suppliers

HUNAN CHEMFISH SCIENTIFIC CO.,LTD
Tel
+86-0731-85567275 18932438858
Fax
QQ:3554193828
Email
sales05@chemfish.com
Country
China
ProdList
8301
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
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View Lastest Price from Methylergonovine maleate salt manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Methylergonovine maleate salt 57432-61-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
6000 kg
Release date
2023-08-15
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Methylergonovine maleate salt 57432-61-8
Price
US $220.00/KG
Min. Order
0.10000000149011612KG
Purity
99% min
Supply Ability
20 TONS
Release date
2023-04-10
Shaanxi Dideu Medichem Co. Ltd
Product
Methylergonovine maleate salt 57432-61-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26

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