Methylergonovine maleate salt

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Methylergonovine maleate salt

Product Name: Methylergonovine maleate salt
CAS No.: 57432-61-8
Chemical Name: Methylergonovine maleate salt
Synonyms: Erezin;Derganin;Partan M;erezingen;Metenarin;Methergin;methergine;Ryegonovin;Basofortina;Spametrin F
CBNumber: CB6343310
Molecular Formula: C24H29N3O6
Formula Weight: 455.51
MOL File: 57432-61-8.mol

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Methylergonovine maleate salt Property

Melting point:: 1720C (dec)
Boiling point:: 561.98°C (rough estimate)
Density: 1.2744 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: -20°C Freezer
solubility: H₂O: 25 mg/mL
color: white
Water Solubility: Soluble to 25 mM in water

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Safety

Hazard Codes: T
Risk Statements: 23/24/25-62
Safety Statements: 36/37/39-45
RIDADR: UN 1544 6.1/PG 3
WGK Germany: 3
RTECS: KE5500000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2939690000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1430000
Product name: Methylergonovine maleate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $261.6
Updated: 2024/03/01

Tocris

Product number: 0549
Product name: Methylergometrinemaleate
Purity: ≥98%(HPLC)
Packaging: 250
Price: $473
Updated: 2021/12/16

Tocris

Product number: 0549
Product name: Methylergometrinemaleate
Purity: ≥98%(HPLC)
Packaging: 50
Price: $116
Updated: 2021/12/16

Usbiological

Product number: 255800
Product name: Methylergometrine maleate
Packaging: 50mg
Price: $366
Updated: 2021/12/16

Usbiological

Product number: 016814
Product name: Methyl Ergonovine Maleate Salt
Packaging: 5mg
Price: $460
Updated: 2021/12/16

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Methylergonovine maleate salt Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Methergine,Sandoz,US,1948

Uses

A metabolite of Methysergide. Semisynthetic ergot alkaloid. Oxytocic

Definition

ChEBI: Methylergonovine Maleate is an ergoline alkaloid. It has a role as a geroprotector.

Manufacturing Process

To a freshly prepared solution of 2 parts of d-isolysergic acid azide in 300 parts of either is added an ethereal solution of 2 parts of d-2-aminobutanol-1 and the mixture is left to stand at room temperature during 12 hours. The yellowish clear solution is then washed several times with some water, dried over sodium sulfate and the ether evaporated in vacuo. The crystallized residue is treated with a small quantity of acetone and filtered. Yield: 2.2 parts of d-isolysergic acid-d-1-hydroxybutylamide-2. On recrystallization from some hot methanol the new compound is obtained in form of beautiful polygonal crystals that melt with some decomposition at 192° to 194°C (corr.).
1 part of the iso-compound is then dissolved in 10 parts of absolute ethanol and an alcoholic potassium hydroxide solution is added thereto. The mixture is left to stand at room temperature during 45 minutes. After this time equilibrium is reached between lysergic acid and the isolysergic acid forms, which can be checked by determination of the constancy of the optical rotation of the solution. When this point is reached, potassium hydroxide is transformed into potassium carbonate by bubbling through the solution a stream of carbon dioxide; the thick crystal paste of potassium carbonate is then diluted with 50 parts of ether, filtered and washed again with 50 parts of ether.
The alcoholic ethereal filtrate is then dried over calcined potassium carbonate and the solution evaporated, whereby 0.9 to 1 part of a mixture of d-lysergic acid-d-1-hydroxybutylamide-2 and of d-isolysergic acid-d-1- hydroxybutylamide-2 is obtained. In order to separate the isomers, the residue is dissolved in 15 parts of hot chloroform and filtered from the small quantity of inorganic salt, whereby on cooling down, the difficultly soluble chloroform compound of d-lysergic acid-d-1-hydroxybutylamide-2 crystallizes out. Yield: 0.4 part. This compound can be recrystallized from hot benzene, whereby crystals melting with some decomposition at 172°C (corr.) are obtained. It may then be reacted with maleic acid to give the maleate.

brand name

Methergine(Novartis).

Therapeutic Function

Oxytocic

storage

Desiccate at RT

Methylergonovine maleate salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methylergonovine maleate salt manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methylergonovine maleate salt 57432-61-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Hebei Yanxi Chemical Co., Ltd.

Product: Methylergonovine maleate salt 57432-61-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 6000 kg
Release date: 2023-08-15

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Methylergonovine maleate salt 57432-61-8
Price: US $220.00/KG
Min. Order: 0.10000000149011612KG
Purity: 99% min
Supply Ability: 20 TONS
Release date: 2023-04-10

57432-61-8, Methylergonovine maleate saltRelated Search:

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9,10-DIDEHYDRO-N-[(S)-1-(HYDROXYMETHYL)PROPYL]-6-METHYLERGOLINE-8BETA-CARBOXAMIDE MALEATE SALT

[8B(S)]-9,10-DIDEHYDRO-N-[1-(HYDROXYMETHYL)PROPYL]-6-METHYLERGOLINE-8-CARBOXAMIDE MALEATE

methergine

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Basofortina

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N-[a-(Hydroxymethyl)propyl]-D-lysergamide Maleate

9,10-didehydro-n-[(s)-1-(hydroxymethyl)propyl]-6-methylergoline-8β-carboxamide maleate salt

Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8b)-, (2Z)-2-butenedioate (1:1) (salt) (9CI)

Ergonovine, methyl-, compd. with maleic acid (6CI)

Ryegonovin

Spametrin F

(8)-9,10-Didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-ergoline-8-carbox-amide Maleate

Methergine maleate salt, 9,10-Didehydro-N-[(S)-1-(hydroxymethyl)propyl]-6-methylergoline-8β-carboxamide maleate salt

Derganin

Partan M

Einecs 260-734-4

Ergoline-8-carboxamide, 9,10-didehydro-N-((1S)-1-(hydroxymethyl)propyl)-6-methyl-, (8beta)-, (2Z)-2-butenedioate (1:1) (salt)

Ergoline-8-carboxamide, 9,10-didehydro-N-(1-(hydroxymethyl)propyl)-6-methyl-, (8beta(S))-, (Z)-2-butenedioate (1:1) (salt)

Ergonovine, methyl-, maleate (1:1)

Methylergonovine Maleate (50 mg) (List Chemical)

N-[α-(HydroxyMethyl)propyl]-D-lysergaMide Maleate

Methergine maleate salt

Methylergometrine for system suitability -* Drug Precursor -*narc CRS

Methylergometrine maleate CRS

(6aR,9R)-N-[(1S)-1-(Hydroxymethyl)propyl]-7-methyl- 4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (Z)-butenedioate

Methylergonovine maleate salt USP/EP/BP

Methylergonovine MaleateQ: What is Methylergonovine Maleate Q: What is the CAS Number of Methylergonovine Maleate Q: What is the storage condition of Methylergonovine Maleate Q: What are the applications of Methylergonovine Maleate

Methylergonovine Maleate (1430000)

Methylergonovine Maleate，Methylergonovine maleate salt

(6aR,9R)-N-((R)-1-hydroxybutan-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide maleate

57432-61-8

C20H25N3O2C4H4O4

METHERGINE

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