ChemicalBook > CAS DataBase List > Molnupiravir
Molnupiravir
- Product Name
- Molnupiravir
- CAS No.
- 2492423-29-5
- Chemical Name
- Molnupiravir
- Synonyms
- Molnupiravir-001-QA;Molnupiravir In-House;Uridine, 4-oxime, 5'-(2-methylpropanoate), (4Z)-;Molnupiravir D7Q: What is Molnupiravir D7 Q: What is the CAS Number of Molnupiravir D7;(2R,3S,4R,5R)-3,4-dihydroxy-5-[(4Z)-4-hydroxyimino-2-oxo-pyrimidin-1-yl]tetrahydrofuran-2-yl]methyl 2-methylpropanoate;((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate;MolnupiravirQ: What is Molnupiravir Q: What is the CAS Number of Molnupiravir Q: What is the storage condition of Molnupiravir;((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (Molnupiravir Impurity)
- CBNumber
- CB08369543
- Molecular Formula
- C13H19N3O7
- Formula Weight
- 329.31
- MOL File
- 2492423-29-5.mol
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Molnupiravir Property
- Density
- 1.62±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)
- pka
- 6.71±0.20(Predicted)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0114880
- Product name
- Molnupiravir
- Purity
- 99.94%
- Packaging
- 200mg
- Price
- $450
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0114880
- Product name
- Molnupiravir
- Purity
- 99.94%
- Packaging
- 500mg
- Price
- $950
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0114880
- Product name
- Molnupiravir
- Purity
- 99.94%
- Packaging
- 1g
- Price
- $1550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0114880
- Product name
- Molnupiravir
- Purity
- 99.94%
- Packaging
- 25mg
- Price
- $90
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0114880
- Product name
- Molnupiravir
- Purity
- 99.94%
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
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Molnupiravir Chemical Properties,Usage,Production
Description
Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection.
Definition
ChEBI: Molnupiravir is a nucleoside analogue that is N(4)-hydroxycytidine in which the 5'-hydroxy group is replaced by a (2-methylpropanoyl)oxy group. It is the prodrug of the active antiviral ribonucleoside analog N(4)-hydroxycytidine (EIDD-1931), has activity against a number of RNA viruses including SARS-CoV-2, MERS-CoV, and seasonal and pandemic influenza viruses. It is currently in phase III trials for the treatment of patients with COVID-19. It has a role as a prodrug, an anticoronaviral agent and an antiviral drug. It is a nucleoside analogue, an isopropyl ester and a ketoxime. It is functionally related to a N(4)-hydroxycytidine.
Biological Activity
Molnupiravir is a broad-spectrum antiviral prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC). It competes predominantly with CTP for incorporation; it induces lethal viral mutagenesis by increasing G to A and C to U transition mutations without inhibition of RNA synthesis in replicating coronaviruses, which prevents the development of viral resistance. In primary airway epithelial cell cultures, Molnupiravir dose-dependently inhibits SARS-CoV-2 infectious virus production; it also inhibits MERS-CoV and SARS-CoV with EC50 values in the submicromolar range. In mice infected with SARS-CoV or MERS-CoV, it improves pulmonary function, and reduces virus titer and body weight loss. Molnupiravir also displays in vivo efficacy against seasonal and pandemic influenza A shed virus. It is orally bioavailable.
storage
Store at -20°C
Molnupiravir Preparation Products And Raw materials
Raw materials
Preparation Products
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2492423-29-5, Molnupiravir Related Search:
((2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl)methyl isobutyrate
Uridine, 5'-(2-methylpropanoate) (9CI)
Uridine, 4-oxime, 5'-(2-methylpropanoate), (4E)-
2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI)
6-HYDROXYLAMINOURACIL
2',3'-O-isopropylidene cytidine
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
N(4)-hydroxycytidine