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Molnupiravir

Product Name
Molnupiravir
CAS No.
2492423-29-5
Chemical Name
Molnupiravir
Synonyms
Molnupiravir-IHS/IP;Molnupiravir-001-QA;Molnupiravir In-House;Molnupiravir, 10 mM in DMSO;Uridine, 4-oxime, 5'-(2-methylpropanoate), (4Z)-;Molnupiravir D7Q: What is Molnupiravir D7 Q: What is the CAS Number of Molnupiravir D7;[(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl 2-methylpropanoate;(2R,3S,4R,5R)-3,4-dihydroxy-5-[(4Z)-4-hydroxyimino-2-oxo-pyrimidin-1-yl]tetrahydrofuran-2-yl]methyl 2-methylpropanoate;((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate;MolnupiravirQ: What is Molnupiravir Q: What is the CAS Number of Molnupiravir Q: What is the storage condition of Molnupiravir
CBNumber
CB08369543
Molecular Formula
C13H19N3O7
Formula Weight
329.31
MOL File
2492423-29-5.mol
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Molnupiravir Property

Density 
1.62±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)
form 
Solid
pka
6.71±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0114880
Product name
Molnupiravir
Purity
99.94%
Packaging
200mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0114880
Product name
Molnupiravir
Purity
99.94%
Packaging
500mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0114880
Product name
Molnupiravir
Purity
99.94%
Packaging
1g
Price
$1550
Updated
2021/12/16
ChemScene
Product number
CS-0114880
Product name
Molnupiravir
Purity
99.94%
Packaging
25mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0114880
Product name
Molnupiravir
Purity
99.94%
Packaging
50mg
Price
$150
Updated
2021/12/16
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Molnupiravir Chemical Properties,Usage,Production

Description

Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection.

Definition

ChEBI: Molnupiravir is a nucleoside analogue that is N(4)-hydroxycytidine in which the 5'-hydroxy group is replaced by a (2-methylpropanoyl)oxy group. It is the prodrug of the active antiviral ribonucleoside analog N(4)-hydroxycytidine (EIDD-1931), has activity against a number of RNA viruses including SARS-CoV-2, MERS-CoV, and seasonal and pandemic influenza viruses. It is currently in phase III trials for the treatment of patients with COVID-19. It has a role as a prodrug, an anticoronaviral agent and an antiviral drug. It is a nucleoside analogue, an isopropyl ester and a ketoxime. It is functionally related to a N(4)-hydroxycytidine.

Biological Activity

Molnupiravir is a broad-spectrum antiviral prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC). It competes predominantly with CTP for incorporation; it induces lethal viral mutagenesis by increasing G to A and C to U transition mutations without inhibition of RNA synthesis in replicating coronaviruses, which prevents the development of viral resistance. In primary airway epithelial cell cultures, Molnupiravir dose-dependently inhibits SARS-CoV-2 infectious virus production; it also inhibits MERS-CoV and SARS-CoV with EC50 values in the submicromolar range. In mice infected with SARS-CoV or MERS-CoV, it improves pulmonary function, and reduces virus titer and body weight loss. Molnupiravir also displays in vivo efficacy against seasonal and pandemic influenza A shed virus. It is orally bioavailable.

storage

Store at -20°C

Molnupiravir Preparation Products And Raw materials

Raw materials

Preparation Products

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Molnupiravir Suppliers

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2492423-29-5, Molnupiravir Related Search:

((2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl)methyl isobutyrate Uridine, 5'-(2-methylpropanoate) (9CI) Uridine, 4-oxime, 5'-(2-methylpropanoate), (4E)- 2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI) 6-HYDROXYLAMINOURACIL 2',3'-O-isopropylidene cytidine 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one N(4)-hydroxycytidine

  • Uridine, 4-oxime, 5'-(2-methylpropanoate), (4Z)-
  • Molnupiravir-001-QA
  • Molnupiravir D7Q: What is Molnupiravir D7 Q: What is the CAS Number of Molnupiravir D7
  • MolnupiravirQ: What is Molnupiravir Q: What is the CAS Number of Molnupiravir Q: What is the storage condition of Molnupiravir
  • ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
  • Molnupiravir In-House
  • ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (Molnupiravir Impurity)
  • (2R,3S,4R,5R)-3,4-dihydroxy-5-[(4Z)-4-hydroxyimino-2-oxo-pyrimidin-1-yl]tetrahydrofuran-2-yl]methyl 2-methylpropanoate
  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl 2-methylpropanoate
  • Molnupiravir-IHS/IP
  • Molnupiravir, 10 mM in DMSO
  • 2492423-29-5