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N(4)-hydroxycytidine

Product Name
N(4)-hydroxycytidine
CAS No.
3258-02-4
Chemical Name
N(4)-hydroxycytidine
Synonyms
EIDD-1931;N-Hydroxycytidine;0/4/58;EIDD-193;Uridine, 4-oxime;Monovir impurity A;EIDD 2801-metabolit;EIDD2801-metabolite;N(4)-hydroxycytidine;EIDD-2801-metabolite
CBNumber
CB21312265
Molecular Formula
C9H13N3O6
Formula Weight
259.22
MOL File
3258-02-4.mol
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N(4)-hydroxycytidine Property

Melting point:
169-172 °C(Solv: methanol (67-56-1))
Density 
1.93±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 15 mg/ml with warming).
pka
8.19±0.20(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2872
Product name
EIDD-1931
Purity
≥98% (HPLC)
Packaging
5MG
Price
$94.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2872
Product name
EIDD-1931
Purity
≥98% (HPLC)
Packaging
25MG
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
9002958
Product name
EIDD-1931
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
9002958
Product name
EIDD-1931
Packaging
5mg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
9002958
Product name
EIDD-1931
Packaging
10mg
Price
$155
Updated
2024/03/01
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N(4)-hydroxycytidine Chemical Properties,Usage,Production

Description

EIDD-1931 is a ribonucleoside analog with antiviral activity. It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s =0.1, 0.15 and 0.3 μM, respectively). It also reduces viral titers of Venezuelan equine encephalitis virus (VEEV) TC-83 in infected Vero cells (EC50 = 0.426 μM) and wild-type and remdesivir-resistant strains of the model CoV mouse hepatitis virus (MHV) in infected DBT cells. EIDD-1931 (100 and 400 mg/kg twice per day) reduces lung viral titers in mouse models of respiratory syncytial virus (RSV) and H1N1 influenza A virus infection.

Uses

EIDD 1931 is an orally bioavailable broad-spectrum antiviral that inhibits SARS-CoV-2 and other multiple endemic, epidemic and bat coronavirus and has the potential for seasonal and pandemic influenza treatment. A broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses.

Definition

ChEBI: N(4)-hydroxycytidine is a nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV. It has a role as a drug metabolite, a human xenobiotic metabolite, an anticoronaviral agent and an antiviral agent. It is a nucleoside analogue and a ketoxime. It is functionally related to a cytidine.

storage

Store at -20°C

References

1) Janion and Glickman (1980),?N4-hydroxycytidine: a mutagen specific for AT to GC transitions;?Mutat. Res.,?72?43 2) Stuyver?et al.?(2003),?Ribonucleotide analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture; Antimicrob. Agents Chemother.,?47?244 3) Costantini?et al.?(2012),?Antiviral activity of nucleoside analogues against norovirus; Antivir. Ther.,?17?981 4) Reynard?et al.?(2015),?Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication; Viruses,?7?6233 5) Ehteshami?et al.?(2017),?Characterization of ?-D-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus; Antimicrob. Agents Chemother.,?61?e02395-16 6) Yoon?et al.?(2018),?Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses; Antimicrob. Agents Chemother.,?62?e00766-18 7) Barnard?et al.?(2004),?Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine; Antivir. Chem. Chemother., 15 15 8) Pyrc et al. (2006),?Inhibition of human coronavirus NL63 infection at early stages of the replication cycle; Antimicrob. Agents Chemother.,?50?2000 9) Toots et al. (2019),?Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia; Sci. Transl. Med.,?11?eaax5866

N(4)-hydroxycytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N(4)-hydroxycytidine Suppliers

China 98 India 5 South Korea 1 United States 7 Global 111
Fuyang Ziyi Biological Pharmaceutical Co., Ltd.
Tel
19308655899
Fax
-
Email
2677609105@qq.com
Country
China
ProdList
464
Advantage
58
Shanghai Hecheng Medical Technology Co., LTD
Tel
13564747822
Fax
QQ774046800
Email
669027880@qq.com
Country
China
ProdList
957
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
5021
Advantage
58
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17989
Advantage
64
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3421
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17994
Advantage
56
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16687
Advantage
50
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View Lastest Price from N(4)-hydroxycytidine manufacturers

Shanghai Biolang Biotechnology Co., Ltd.
Product
N(4)-hydroxycytidine 3258-02-4
Price
US $9.90-8.80/g
Min. Order
10g
Purity
99.99%HPLC.USP42
Supply Ability
1000kgs
Release date
2022-02-10

3258-02-4, N(4)-hydroxycytidineRelated Search:

Molnupiravir PF-01367338 RESINIFERATOXIN N-Eicosanoyl Serotonin Imiquimod ((2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl)methyl isobutyrate Uridine, 5'-(2-methylpropanoate) (9CI) Cytidine, 2',3'-O-(1-methylethylidene)-, 5'-(2-methylpropanoate) ((3aR,4R,6R,6aR)-6-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Uridine, 4-oxime, 5'-(2-methylpropanoate), (4E)- 2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI) 6-HYDROXYLAMINOURACIL 2',3'-O-isopropylidene cytidine 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one Molnupiravir Impurity 5

  • N(4)-hydroxycytidine
  • 1-[(2R)-3α,4α-Dihydroxy-5β-(hydroxymethyl)oxolane-2β-yl]-4-(hydroxyamino)pyrimidine-2(1H)-one
  • 3,4-Dihydro-1-β-D-ribofuranosyl-4-(hydroxyimino)pyrimidin-2(1H)-one
  • N-Hydroxycytidine
  • β-D-N4-Hydroxycytidine
  • Beta-d-N4-hydroxycytidine
  • EIDD-1931
  • Beta-d-N4-hydroxycytidine (NHC)
  • Uridine, 4-oxime
  • EIDD2801 ,β-D-N4-hydroxycytidine
  • EIDD-193
  • Molnupiravir Impurity 1
  • Molnupiravir Impurity A/N-hydroxycytidine
  • 0/4/58
  • EIDD-1931 (Beta-d-N4-hydroxycytidine
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-oneQ: What is 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the CAS Number of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the storage condition of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
  • N-Hydroxycytidine (EIDD-1931) for cell culture, 98%, Endotoxin (BET) 0.05EU/mg
  • Chikungunya,equine,Enterovirus,HEV,EIDD 1931,HRV,Hepatitis C virus,Inhibitor,EIDD1931,CHIKV,Topoisomerase,Enterovirus,VEEV,HEVs,NHC,Rhinovirus,HCV,encephalitis,SARS-CoV,EIDD-1931,inhibit,venezuelan,HRVs,SARS coronavirus
  • 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-4-(Hydroxyamino)Pyrimidin-2-One
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one (Molnupiravir Impurity)
  • Monovir impurity A
  • N4-Hydroxycytidine (NHC)
  • EIDD 2801-metabolit
  • EIDD-2801-metabolite
  • EIDD2801-metabolite
  • 3258-02-4
  • 328-02-4