Cyanogen chloride Property

Melting point:

-6°

Boiling point:

14°C

Density 

1.186

vapor pressure 

60kPa at 0℃

solubility 

soluble in H2O, ethanol, ethyl ether

form 

colorless gas

color 

colorless vol liquid or gas

Water Solubility 

soluble H2O, ether, alcohol [MER06]

Exposure limits

Ceiling limit 0.7 mg/m³ (0.3 ppm) (ACGIH).

LogP

0.64 at 20℃

CAS DataBase Reference

506-77-4

NIST Chemistry Reference

Cyanogen chloride(506-77-4)

EPA Substance Registry System

Cyanogen chloride (506-77-4)

Safety

Hazard Codes 

T

RIDADR 

UN 1589

OEL

Ceiling: 0.3 ppm (0.6 mg/m3)

HazardClass 

2.3

Hazardous Substances Data

506-77-4(Hazardous Substances Data)

Toxicity

CK may polymerize violently if contaminated with hydrogen chloride or ammonium chloride. Upon heating, it decomposes, producing toxic and corrosive fumes of hydrogen cyanide, hydrochloric acid, and nitrogen oxides. Hazardous polymerization can occur. Cyanogen chloride will react slowly with water to form hydrogen chloride gas. It acts on the body in two ways. Systemic effects of CK are much like those of hydrogen cyanide. Additionally, it causes irritation of the eyes, upper respiratory tract, and lungs. Eye irritation results in tearing. CK, like AC, stimulates the respiratory system and rapidly paralyzes it. Exposure is followed by immediate, intense irritation of the nose, throat, and eyes, with coughing, tightness in the chest, and lacrimation. This is followed by dizziness and increasing difficulty breathing. Unconsciousness comes next, with failing respiration and death within a few minutes. Convulsions, retching, and involuntary urination and defecation may occur. If these effects are not fatal, the signs and symptoms of pulmonary edema may develop. There may be repeated coughing, with profuse foamy sputum, rales in the chest, severe dyspnea, and distinct cyanosis. Recovery from the systemic effects is usually as prompt as in AC poisoning. However, a higher incidence of residual damage to the central nervous system should be expected. Based upon the concentration of the cyanogen chloride to which the victim has been exposed, the pulmonary effects may evolve instantly or may be delayed until the systemic effects have subsided. Consequently, early prognosis must be cautious.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H280Contains gas under pressure; may explode if heated

H314Causes severe skin burns and eye damage

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P410+P403Protect from sunlight. Store in a well-ventilated place.

P501Dispose of contents/container to..…

Cyanogen chloride Chemical Properties,Usage,Production

Description

Cyanide poisoning was first reported with the effects of extract of bitter almonds; then cyanide was identified and isolated from cherry laurel. Cyanogen chloride was first prepared in 1787 by the action of chlorine upon hydrocyanic acid (aka prussic acid) and was called ‘oxidized prussic acid.’ The correct formula for cyanogen chloride was first established in 1815. Cyanogen chloride was used in World War I in 1916.

Chemical Properties

Cyanogen chloride is a colorless gas or liquid (below 55℃ F/13℃ ) with a pungent, irritating odor. Shipped as a liquefied gas. A solid below—6℃ .

History

Cyanogen chloride (CK) is a very volatile compound, but is less a fire or explosive hazard than hydrogen cyanide and therefore logistically speaking less problematic. (Industry has found cyanogen chloride the preferred reactant in processes to make synthetic rubber). Reportedly, France combined hydrocyanic acid with cyanogen chloride in World War I ("manguinite"). The use of cyanogen chloride in this mixture was intended as an irritant to make soldiers remove their masks, exposing themselves to these very toxic gases. Cyanogen chloride was also combined with arsenic trichloride later on in the war. Like hydrocyanic acid, cyanogen chloride tends to spontaneously polymerize and therefore was combined with stabilizers (sodium pyrophosphate) for longer shelf life.

Uses

Cyanogen chloride is used in organic synthesis and as a military poisonous gas. Several benzene derivatives react with chloramine or with hypochlorous acid in the presence of ammonium ion to form cyanogen chloride (Maeda et al. 1987).

Uses

Organic synthesis; poison gas used by military

Uses

In chemical synthesis. Military poison gas.

Production Methods

Cyanogen chloride is produced by the action of chlorine on moist sodium cyanide suspended in carbon tetrachloride and kept cooled to -3°C, followed by distillation.

General Description

A colorless gas or liquid with a strong acrid/pungent odor. Boils at 60°F. Liquid density 10.0 lb / gal. Shipped as a liquid confined under its own vapor pressure. A highly toxic lachrymator. Has been used as a tear gas. Vapor is heavier than air. Prolonged exposure of the container to fire or intense heat may cause violent rupturing and rocketing.

Air & Water Reactions

Soluble in water. Very slow reaction with water to form hydrogen cyanide.

Reactivity Profile

CYANOGEN CHLORIDE may trimerize violently to form cyanuric chloride, catalyzed by hydrogen chloride or ammonium chloride. Reacts exothermically with alkenes and alkynes. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullman Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.).

Hazard

Cyanogen chloride becomes volatile as temperatures increase, and the DOT lists it as a 2.3 poison gas. The NFPA 704 designation for CK is estimated to be health 4, flammability 0,reactivity 2, and special ?0. Cyanogen chloride vapors are highly toxic. It has a four-digit UN identification number of 1589 (inhibited). Treatment for either AC or CK poisoning is to follow the treatment protocols for airway, breathing, and circulation (ABCs) and administer oxygen to assist breathing. Instructions for administration and dosage should be based on local protocols and with the advice of a physician. Sodium nitrate is administered to produce methemoglobin, thus seizing the cyanide on the methemoglobin. The sodium thiosulfate combines with the confiscated cyanide to form thiocyanate, which is then excreted from the body.

Health Hazard

Cyanogen chloride is a highly poisonous compound and a severe irritant. In humans, exposure to 1 ppm for 10 minutes caused severe irritation of eyes and nose. Irritation of respiratory tract is followed by hemorrhage of the bronchi and trachea, as well as pulmonary edema.
The toxicity of cyanogen chloride is attributed to its relatively easy decomposition to cyanide ion in an aqueous medium. The cyanide attacks the cells in the body and interferes with the cellular metabolism. Tests on rats indicated that exposure to cyanogen chloride caused lacrimation and chronic pulmonary edema and somnolence. At a high concentration of 300 ppm, death occurred to the test animals. Inhalation of 48 ppm for 30 minutes was fatal to humans. In animals, subcutaneous intakes of 5 and 15 mg/kg were lethal to both dogs and rabbits.
Chronic exposure to cyanogen chloride can cause conjunctivitis and edema of the eyelid.

Health Hazard

VAPOR: POISONOUS IF INHALED OR IF SKIN IS EXPOSED. Irritating to eyes. LIQUID: POISONOUS IF SWALLOWED. Will burn skin and eyes.

Fire Hazard

Not flammable. POISONOUS GASES ARE PRODUCED WHEN HEATED IN FIRE. Overheated containers can explode.

Safety Profile

Poison by ingestion, subcutaneous, and possibly other routes. Toxic by inhalation. Human systemic effects by inhalation: lachrymation, conjunctiva irritation, and chronic pulmonary edema or congestion. A primary irritant. A severe human eye irritant. An insecticide. Flammable when exposed to heat or flame. When heated to decomposition or on contact with water or steam, it will react to produce highly toxic and corrosive fumes of Cl-, CN-, and NOx. See also other cyanogen entries, CYANIDE, and CHLORIDES.

Potential Exposure

Cyanaogen chloride is used as a fumi- gant, metal cleaner; in ore refining; production of synthetic rubber and in chemical synthesis. CK is used as a military poison gas (blood agent). It forms cyanide in the body.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24-48 h after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonaryedema, a doctor or authorized paramedic may consideradministering a corticosteroid spray. If frostbite hasoccurred, seek medical attention immediately; do NOT rubthe affected areas or flush them with water. In order toprevent further tissue damage, do NOT attempt to removefrozen clothing from frostbitten areas. If frostbite has NOToccurred, immediately and thoroughly wash contaminatedskin with soap and water.
Use amyl nitrate capsules if symptoms develop. All areaemployees should be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidotekit should be kept in the immediate work area and must berapidly available. Kit ingredients should be replaced every1-2 years to ensure freshness. Persons trained in the use ofthis kit, oxygen use, and CPR must be quickly available.

Environmental Fate

The primary effect of cyanide poisoning results from the inhibition of the metal-containing enzymes, specifically, cytochrome oxidase a3 (containing iron) within the mitochondria. Cyanide poisons the mitochondrial electron transport chain within cells and renders the body unable to derive energy (ATP) from oxygen, therefore causing rapid death. Other mechanisms include pulmonary arteriolar and/or coronary vasoconstriction that results in cardiogenic shock and pulmonary edema. Cyanide can also directly stimulate chemoreceptors in the aorta and carotid artery, causing hyperpnea.

storage

Corrosive, Toxic gas. Color Code—Yellow Stripe:Reactivity Hazard; Store separately in an area isolated fromflammables, combustibles, or other yellow-coded materials.Prior to working with this chemical you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area. Provide ventilation along the floor as the vapors are heavier than air.Procedures for the handling, use, and storage of cylindersshould be in compliance with OSHA 1910.101 and1910.169, as with the recommendations of the CompressedGas Association.

Shipping

UN1589 Cyanogen chloride, stabilized, Hazard Class: 2.3; Labels: 2.3-Poisonous gas, 8-Corrosive material Inhalation Hazard Zone A. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written per- mission of the owner. Military driver shall be given full and complete information regarding shipment and condi- tions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.

Toxicity evaluation

At room temperature, cyanogen chloride is a colorless gas with a pungent, biting odor that has been described as ‘pepper-like.’ Cyanogen chloride is soluble in both water (6.00E + 04 mg l^-1) and most organic solvents (e.g., chloroform, ethanol, or benzene); however, such mixtures often are unstable.
Based on the high volatility and rapid hydrolysis of cyanogen chloride, its adsorption to soil and sediment is not an important environmental fate process. Estimated vapor pressure of 1230 mmHg suggests that cyanogen chloride will volatilize rapidly from water surfaces and it is expected to volatilize from dry soil surfaces.

Incompatibilities

CK is incompatible with; or, may react with most basic and acidic solvents. CK reacts slowly with water or water vapor forming toxic hydrogen cyanide and hydrogen chloride. Cyanogen chloride may polymerize vio- lently if contaminated with chlorine. CK is unstable; it may be stabilized (i.e., inhibited) to prevent polymerization. In crude form CK trimerizes violently if catalyzed by traces of hydrogen chloride or ammonium chloride. Contact with alcohols, acids, acid salts; amines, strong alkalis; olefins, and strong oxidizers may cause fire and explosion. Heat causes decomposition producing toxic and corrosive fumes of hydrogen cyanide, hydrochloric acid, nitrogen oxides. Reacts slowly with water or water vapor, forming hydrogen chloride. Attacks copper, brass, and bronze in the presence of moisture.

Waste Disposal

Return refillable compressed gas cylinders to supplier. React with strong calcium hypo- chlorite solution for 24 hours, then flush to sewer with large volumes of water.