ChemicalBook > CAS DataBase List > 2-chloro 3,5-dimethyl pyarazine
2-chloro 3,5-dimethyl pyarazine
- Product Name
- 2-chloro 3,5-dimethyl pyarazine
- CAS No.
- 38557-72-1
- Chemical Name
- 2-chloro 3,5-dimethyl pyarazine
- Synonyms
- 2-Chloro-3,5-dimethylpyrazine;2-chloro 3,5-dimethyl pyarazine;Pyrazine, 2-chloro-3,5-dimethyl-;2-Chloro-3,5-dimethyl-1,4-diazine;2-Chloro-3,5-dimethylpyrazine 97%
- CBNumber
- CB0853583
- Molecular Formula
- C6H7ClN2
- Formula Weight
- 142.59
- MOL File
- 38557-72-1.mol
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2-chloro 3,5-dimethyl pyarazine Property
- Boiling point:
- 186.6±35.0℃ (760 Torr)
- Density
- 1.184±0.06 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.5230 to 1.5270
- Flash point:
- 83.1±11.5℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- pka
- 0.47±0.10(Predicted)
- form
- Oil
- color
- Colourless
- CAS DataBase Reference
- 38557-72-1
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Safety
- Risk Statements
- 36/38
- Safety Statements
- 23-26-36/37/39
- RIDADR
- 1993
- Hazard Note
- Harmful
- HazardClass
- 3
- PackingGroup
- Ⅲ
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- C3118
- Product name
- 2-Chloro-3,5-dimethylpyrazine
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $159
- Updated
- 2025/07/31
TRC
- Product number
- C365605
- Product name
- 2-Chloro-3,5-dimethylpyrazine
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
Usbiological
- Product number
- 159473
- Product name
- 2-Chloro-3,5-dimethylpyrazine
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 083947
- Product name
- 2-Chloro-3,5-dimethylpyrazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $267
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC139622
- Product name
- 2-Chloro-3,5-dimethylpyrazine
- Packaging
- 10g
- Price
- $670
- Updated
- 2021/12/16
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2-chloro 3,5-dimethyl pyarazine Chemical Properties,Usage,Production
Uses
2-Chloro-3,5-dimethylpyrazine, is a halogenated pyrazine, that can be used as an intermediates in chemical synthesis.
Synthesis
108-50-9
38557-72-1
The general procedure for the synthesis of 2-chloro-3,5-dimethylpyrazine from 2,6-dimethylpyrazine was as follows: first, 7.12 g of 2,6-dimethylpyrazine and 6.5 mL of dimethylformamide (DMF) were added to a three-necked flask fitted with a dropping funnel and a thermometer, and refluxed under nitrogen protection. Subsequently, 6.7 mL of thionyl chloride was added to the dropping funnel and the reaction vessel was cooled in an ice bath. Thionyl chloride was slowly added dropwise while stirring the reaction mixture, controlling the reaction temperature in the range of 45 ± 5 °C. After the dropwise addition was completed, the reaction solution temperature was allowed to drop below 40°C and quenched by slowly adding water. After reconfirming that the temperature of the reaction solution was below 40 °C, aqueous sodium hydroxide was added to adjust the pH to 7-8. Subsequently, the reaction mixture was subjected to hydrodistillation. The distilled aqueous phase was extracted with dichloromethane and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate and filtered, the filtrate was distilled to remove the solvent, and the residue was purified by distillation under reduced pressure to afford the target product 2-chloro-3,5-dimethylpyrazine (clear colorless liquid, 36% yield).
References
[1] Patent: WO2013/112788, 2013, A1. Location in patent: Paragraph 00660
[2] Patent: WO2008/149828, 2008, A1. Location in patent: Page/Page column 80-81; 82
[3] European Journal of Organic Chemistry, 2005, # 19, p. 4141 - 4153
2-chloro 3,5-dimethyl pyarazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-chloro 3,5-dimethyl pyarazine manufacturers
Career Henan Chemical Co
- Product
- 2-chloro 3,5-dimethyl pyarazine 38557-72-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-11
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