2-CHLORO-3-METHYLPYRAZINE
- Product Name
- 2-CHLORO-3-METHYLPYRAZINE
- CAS No.
- 95-58-9
- Chemical Name
- 2-CHLORO-3-METHYLPYRAZINE
- Synonyms
- 2-Chlor-3-methylpyrazin;2-Methyl-3-chloropyrazine;2-CHLORO-3-METHYLPYRAZINE;Pyrazine, 2-chloro-3-methyl-;2-CHLORO-3,(5),(6)-ETHYLPYRAZINE;2-CHLORO-3-METHYLPYRAZINE ISO 9001：2015 REACH
- CBNumber
- CB2385570
- Molecular Formula
- C5H5ClN2
- Formula Weight
- 128.56
- MOL File
- 95-58-9.mol
2-CHLORO-3-METHYLPYRAZINE Property
- Boiling point:
- 80 °C(Press: 27 Torr)
- Density
- 1.234g/ml
- refractive index
- 1.5283
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.31±0.10(Predicted)
- form
- Liquid
- color
- Colorless
- InChI
- InChI=1S/C5H5ClN2/c1-4-5(6)8-3-2-7-4/h2-3H,1H3
- InChIKey
- WZHWPZQQPWKEAV-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CN=C1C
- LogP
- 1.058 (est)
- CAS DataBase Reference
- 95-58-9(CAS DataBase Reference)
- EPA Substance Registry System
- Pyrazine, 2-chloro-3-methyl- (95-58-9)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- TSCA
- Yes
- HS Code
- 2933119000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- W9751
- Product name
- 2-Chloro-3-methylpyrazine
- Packaging
- 10g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- 073362
- Product name
- 2-Chloro-3-methylpyrazine
- Purity
- 90.0
- Packaging
- 25g
- Price
- $380
- Updated
- 2021/12/16
- Product number
- HCH0032899
- Product name
- 2-CHLORO-3-METHYLPYRAZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $744.98
- Updated
- 2021/12/16
- Product number
- HCH0032899
- Product name
- 2-CHLORO-3-METHYLPYRAZINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1253.18
- Updated
- 2021/12/16
- Product number
- HCH0032899
- Product name
- 2-CHLORO-3-METHYLPYRAZINE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1946.18
- Updated
- 2021/12/16
2-CHLORO-3-METHYLPYRAZINE Chemical Properties,Usage,Production
Uses
2-Chloro-3-methylpyrazine is a pyrazine compound in which the chlorine atom in the structure can be replaced for the preparation of other medicinal chemicals. It is used in the preparation of macrocyclic urea kinase inhibitors.
Synthesis
109-08-0
95-58-9
(i) Chlorine gas was passed into carbon tetrachloride (67 mL) at a constant flow rate for 30 minutes. Subsequently, the resulting yellow solution was slowly added dropwise to a solution of carbon tetrachloride (125 mL) containing pyridine (4.8 mL) and 2-methylpyrazine (5 g) over a period of 30 minutes while stirring was maintained. Upon completion of the reaction, the reaction system was purged with nitrogen to remove residual chlorine gas, followed by removal of volatile solvents by rotary evaporation. The resulting brown oily crude product was purified by silica gel column chromatography using dichloromethane as eluent to give 2-chloro-3-methylpyrazine as a final brown oil (3.62 g, 53% yield). The structure of the product was confirmed by 1H NMR (d6-DMSO): δ 6.59 (s, 2H), 7.67 (d, 1H), 7.94 (d, 1H); the mass spectrum (+ve CI) showed the molecular ion peak m/z 129 ([M + H]+).
References
[1] Patent: US5861401, 1999, A
[2] Patent: CN107954913, 2018, A. Location in patent: Paragraph 0021
2-CHLORO-3-METHYLPYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-3-METHYLPYRAZINE manufacturers
- Product
- 2-Chloro-3-methyl-pyrazine 95-58-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 2-Methyl-3-chloropyrazine 95-58-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-28
- Product
- 2-CHLORO-3-METHYLPYRAZINE 95-58-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24