3-Chloropyrazine-2-carbonitrile

Product Name: 3-Chloropyrazine-2-carbonitrile
CAS No.: 55557-52-3
Chemical Name: 3-Chloropyrazine-2-carbonitrile
Synonyms: BUTTPARK 29\04-93;Favipiravir Impurity2;Favipiravir Impurity16;Favipiravir Impurity 32;2-CHLORO-3-CYANOPYRAZINE;3-Chloro-2-cyanopyrazine;2-Chloro-3-cyannopyrazine;oropyrazine-2-carbonitriL;3-Chloropyrazine-2-carbon...;3-Chlorpyrazin-2-carbonitril
CBNumber: CB1105450
Molecular Formula: C5H2ClN3
Formula Weight: 139.54
MOL File: 55557-52-3.mol

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3-Chloropyrazine-2-carbonitrile Property

Melting point:: 45-47°C
Boiling point:: 264.1±35.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -5.41±0.10(Predicted)
form: solid
color: Light brown to black
InChI: InChI=1S/C5H2ClN3/c6-5-4(3-7)8-1-2-9-5/h1-2H
InChIKey: SDLFAEGTVBPHBK-UHFFFAOYSA-N
SMILES: C1(C#N)=NC=CN=C1Cl
CAS DataBase Reference: 55557-52-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-39
RIDADR: 3276
Hazard Note: Harmful
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: C381220
Product name: 3-Chloropyrazine-2-carbonitrile
Packaging: 100g
Price: $470
Updated: 2021/12/16

Matrix Scientific

Product number: 068807
Product name: 3-Chloropyrazine-2-carbonitrile
Purity: >95%
Packaging: 5g
Price: $12
Updated: 2021/12/16

AK Scientific

Product number: X4712
Product name: 2-Chloro-3-cyanopyrazine
Packaging: 5g
Price: $14
Updated: 2021/12/16

Apolloscientific

Product number: OR3400
Product name: 3-Chloropyrazine-2-carbonitrile
Purity: 98%
Packaging: 5g
Price: $18
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-5-01
Product name: 2-Chloro-3-cyanopyrazine
Purity: 98%
Packaging: 5G
Price: $20
Updated: 2021/12/16

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3-Chloropyrazine-2-carbonitrile Chemical Properties,Usage,Production

Uses

3-Chloropyrazine-2-carbonitrile is a reactant in the syntheses of tuberculostatic pyrazine derivatives.

Synthesis

19847-12-2

55557-52-3

General procedure for the synthesis of 2-chloro-3-cyanopyrazine from 2-cyanopyrazine: sulfonyl chloride (21.2 mL, 260.8 mmol) was slowly added to a solution of pyrazine-2-carbonitrile (6.90 g, 65.65 mmol) in toluene (48 mL) and DMF (5 mL) over 10 minutes. The reaction mixture was stirred in an ice bath for 30 minutes, followed by gradual warming to room temperature and continued stirring for 5 hours. After completion of the reaction, the toluene layer was decanted and the residual slightly reddish oily material was extracted three times with ether. The toluene and ether layers were combined, quenched with ice water and cooled in an ice bath. Subsequently, the combined organic layers were neutralized with solid NaHCO3, separated and the aqueous layer was further extracted with ether. All organic layers were combined, washed with water, dried over anhydrous Na2SO4, filtered and the solvent evaporated under reduced pressure to give the crude product 2-chloro-3-cyanopyrazine. The crude product was purified by silica gel column chromatography (eluent: 100% dichloromethane) to afford 3-chloropyrazine-2-carbonitrile (4.7 g, 51% yield) as a white powder. The product characterization data were as follows: Rf = 0.76 (dichloromethane); melting point 44-46 °C (literature value: 47-48 °C); IR (KBr) νmax (cm-1): 3088 (νCHar), 2242 (νCN), 1377 (νC=C), 1087 (νC-N); 1H NMR (400 MHz, DMSO-d6): δ 8.91 (d, 1H, J = 2.4 Hz, H-6), 8.88 (d, 1H, J = 2.4 Hz, H-5); 13C NMR (100 MHz, DMSO-d6): δ 150.67 (C-3), 147.97 (C-5), 144.26 (C-6), 129.87 (C-2), 114.66 (CN); MS (ESI) m/z (%): 140.3 (100) [M + H]+, 142.3 (40) [M + H + 2]+. Elemental analysis (C5H2ClN3) Calculated values: C, 43.04; H, 1.44; N, 30.11. Measured values: C, 43.18; H, 1.45; N, 30.16.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 171 - 183
[2] Patent: EP1582521, 2005, A1. Location in patent: Page/Page column 133-134
[3] Magnetic Resonance in Chemistry, 2009, vol. 47, # 7, p. 617 - 624

3-Chloropyrazine-2-carbonitrile Preparation Products And Raw materials

Raw materials

dimethyldioxirane Trimethylsilyl cyanide Acetonitrile Acetone Zinc chloride 2-Chloropyrazine Triethanolamine

Preparation Products

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3-Chloropyrazine-2-carbonitrile Suppliers

Belgium 1 China 242 France 1 Germany 1 India 5 United Kingdom 13 United States 24 Global 287

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View Lastest Price from 3-Chloropyrazine-2-carbonitrile manufacturers

Moxin Chemicals

Product: Favipiravir Impurity 55557-52-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98
Supply Ability: 10000000
Release date: 2025-02-20

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Chloropyrazine-2-carbonitrile 55557-52-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Nanjing Fred Technology Co., Ltd

Product: 3-Chloropyrazine-2-carbonitrile 55557-52-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-23

55557-52-3, 3-Chloropyrazine-2-carbonitrileRelated Search:

Sulfachoropyrazine sodium N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO 3-OXO-3,4-DIHYDROPYRAZINE-2-CARBONITRILE 2-Chloro-3-cyanopyridine Hydrochlorothiazide Pyrazinamide Glipizide Pyrazinecarboxamide, 3,6-difluoro- (9CI) 6-Bromo-3-chloropyrazine-2-carbonitrile Methyl 6-bromo-3-oxo-3,4-dihydropyrazine-2-carboxylate 3-HYDROXYPYRAZINE-2-CARBOXAMIDE 2-Pyrazinecarbonitrile, 3-fluoro- 3,6-DibroMopyrazine-2-carbonitrile Pyrazinecarboxamide, 5-fluoro-3,4-dihydro-3-oxo- (9CI) Pyrazinecarboxamide, 6-fluoro- (9CI) Difluorochloromethane 3-AMINO-5-CHLOROPYRAZINE-2-CARBONITRILE 5-CHLOROPYRAZINE-2-CARBONITRILE

3-Chloro-2-cyanopyrazine

3-Chloropyrazine-2-carbonitrile, 95+%

2-Chloro-3-cyanopyrazine 95%+

3-chloropyrazin-2-carbonitrile

BUTTPARK 29\04-93

3-CHLOROPYRAZINE-2-CARBONITRILE

2-CHLORO-3-CYANOPYRAZINE

3-CHLOROPYAZINE-2-CARBONITRILE

3-Chloro-2-pyrazinecarbonitrile

C5H2ClN3 Substance Availability 2-chloro-3-cyanopyrazine

2-Chloro-3-cyannopyrazine

3-Chloropyrazine-2-carbon...

2-Chloro-3-cyanopyrazine, 2-Chloro-3-cyano-1,4-diazine

Favipiravir Impurity16

Favipiravir Impurity2

oropyrazine-2-carbonitriL

2-Pyrazinecarbonitrile, 3-chloro-

Favipiravir Impurity 32

3-Chloropyrazine-2-carbonitrile ISO 9001：2015 REACH

AMPZ00203-CHLORO-2-PYRAZINECARBONITRILE

3-Chlorpyrazin-2-carbonitril

55557-52-3

C5H2ClN3

Pyrazines, Pyrimidines & Pyridazines

Intermediates

Pyrazine

pharmacetical

Pyrazines, Pyrimidines & Pyridazines

Pyridazine series