3-CHLORO-2,5-DIMETHYLPYRAZINE

Product Name: 3-CHLORO-2,5-DIMETHYLPYRAZINE
CAS No.: 95-89-6
Chemical Name: 3-CHLORO-2,5-DIMETHYLPYRAZINE
Synonyms: 3-CHLORO-2,5-DIMETHYLPIAZINE;2,5-Dimethyl-3-chloropyrazine;3-CHLORO-2,5-DIMETHYLPYRAZINE;Pyrazine, 3-chloro-2,5-dimethyl-;3-CHLORO-2,5-DIMETHYL-1,4-DIAZINE;3-Chloro-2,5-dimethylpyrazine,93%;3-Chloro-2,5-dimethylpyrazine >3-Chloro-2,5-diMethylpyrazine 98%;3-Chloro-2,5-diMethylpyrazine, 97+%;3-CHLORO-2,5-DIMETHYLPYRAZINE ISO 9001：2015 REACH
CBNumber: CB0176239
Molecular Formula: C6H7ClN2
Formula Weight: 142.59
MOL File: 95-89-6.mol

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3-CHLORO-2,5-DIMETHYLPYRAZINE Property

Boiling point:: 66-69 °C/9 mmHg (lit.)
Density: 1.181 g/mL at 25 °C (lit.)
refractive index: n20/D 1.527(lit.)
Flash point:: 182 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: clear liquid
pka: -0.11±0.10(Predicted)
color: Colorless to Light orange to Yellow
InChIKey: NNBALVIZMGWZHS-UHFFFAOYSA-N
CAS DataBase Reference: 95-89-6(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: UQ2462000
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C38400
Product name: 3-Chloro-2,5-dimethylpyrazine
Purity: 98%
Packaging: 25g
Price: $74.6
Updated: 2023/06/20

TCI Chemical

Product number: C2040
Product name: 3-Chloro-2,5-dimethylpyrazine
Purity: >95.0%(GC)
Packaging: 5g
Price: $104
Updated: 2025/07/31

TRC

Product number: C365855
Product name: 3-Chloro-2,5-dimethylpyrazine
Packaging: 100g
Price: $525
Updated: 2021/12/16

AK Scientific

Product number: W9778
Product name: 3-Chloro-2,5-dimethylpyrazine
Packaging: 1g
Price: $64
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC42536
Product name: 3-Chloro-2,5-dimethylpyrazine
Packaging: 10g
Price: $150
Updated: 2021/12/16

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3-CHLORO-2,5-DIMETHYLPYRAZINE Chemical Properties,Usage,Production

Chemical Properties

Brown liquid

Uses

3-Chloro-2,5-dimethylpyrazine participates in cross-coupling reactions involving chlroropyrazines with 1-substituted indoles. Occasionally this reaction is catalyzed by iron.

Synthesis

6890-37-5

95-89-6

General procedure for the synthesis of 3-chloro-2,5-dimethylpyrazine from 2,5-dimethylpyrazine 1-oxide: 2,5-dimethylpyrazine 1-oxide (7,15.0 g, 121 mmol) and phosphorous trichloride (POCl3, 55.1 g, 360 mmol) were mixed, and the mixture was stirred and heated for 30 min at 60 °C. (Note: Caution is required during handling, as there have been reports of explosions during mixing). Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured in batches into ice water. The pH was adjusted to alkaline with 20% aqueous sodium hydroxide (NaOH) and then extracted with ether (Et2O). The organic phase was washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. Distillation of the residue gave 12.2 g (71% yield) of 3-chloro-2,5-dimethylpyrazine as a light yellow oil with a boiling point of 98-100 °C/40 Torr. Its infrared spectrum (νmax, membrane method) showed characteristic absorption peaks: 3045 (w), 2999 (w), 2962 (w), 2925 (w), 1567 (w), 1519 ( w), 1454 (s), 1377 (m), 1329 (s), 1313 (s), 1248 (m), 1168 (m), 1088 (s), 968 (m), 456 (m) cm-1. NMR hydrogen spectrum (δH, CDCl3): 2.49 (3H, s), 2.59 (3H, s), 8.23 (1H, s); NMR carbon spectrum (δC, CDCl3): 21.2,22.3,142.1,148.3,150.1,151.7.

References

[1] European Journal of Organic Chemistry, 2010, # 14, p. 2687 - 2695
[2] Tetrahedron, 2017, vol. 73, # 32, p. 4766 - 4769
[3] Organic Letters, 2012, vol. 14, # 10, p. 2576 - 2578
[4] Journal of the American Chemical Society, 1951, vol. 73, p. 2949
[5] Journal of the Chemical Society, 1947, p. 1183

3-CHLORO-2,5-DIMETHYLPYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-2,5-DIMETHYLPYRAZINE Suppliers

Americas 1 Belgium 1 Canada 3 China 154 Europe 1 Germany 5 India 4 Japan 2 Switzerland 1 Ukraine 1 United Kingdom 10 United States 33 Global 216

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
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TCI (Shanghai) Development Co., Ltd.

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Ark Pharm, Inc.

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Energy Chemical

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Changzhou Huanling Chemical Co., Ltd.

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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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Accela ChemBio Co.,Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
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ProdList: 42934
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View Lastest Price from 3-CHLORO-2,5-DIMETHYLPYRAZINE manufacturers

Hebei Fengjia New Material Co., Ltd

Product: 3-CHLORO-2,5-DIMETHYLPYRAZINE 95-89-6
Price: US $5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-08-16

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-CHLORO-2,5-DIMETHYLPYRAZINE 95-89-6
Price: US $9.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-05

Honest Joy Holdings Limited

Product: 3-Chloro-2,5-dimethylpyrazine 95-89-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.1%
Supply Ability: 100 tons
Release date: 2022-02-18

95-89-6, 3-CHLORO-2,5-DIMETHYLPYRAZINERelated Search:

LanthanuM(III) chloride hydrate 4-Amino-3-fluoropyridine 3-(4-BROMOBENZOYL)PROPIONIC ACID 2,4-Difluoronitrobenzene Propyleneglycol alginate 4-Bromo-3-fluoroanisole 2,5-Dimethyl pyrazine 3-CHLORO-2,5-DIMETHYLPYRAZINE 3-CHLORO-2,5-DIETHYL PYRAZINE 3-Chloro-5-methyl-pyrazine-2-carboxylic acid methyl ester 2,5-DICHLORO-3,6-DIMETHYLPYRAZINE 2-CHLORO-3,5,6-TRIPHENYLPYRAZINE 2,5-DICHLORO-3,6-DIPHENYL PYRAZINE METHYL 3-CHLORO-5-PHENYLPYRAZINE-2-CARBOXYLATE 2-CHLORO-5-HYDRAZINO-3,6-DIPHENYLPYRAZINE 3-CHLORO-2,6-DIMETHYLPYRAZINE 2,5-DICHLORO-3,6-DIETHYL-PYRAZINE 3-CHLORO-2,5-DIPHENYLPYRAZINE

Pyrazine, 3-chloro-2,5-dimethyl-

3-CHLORO-2,5-DIMETHYL-1,4-DIAZINE

3-CHLORO-2,5-DIMETHYLPIAZINE

3-CHLORO-2,5-DIMETHYLPYRAZINE

2,5-Dimethyl-3-chloropyrazine

3-Chloro-2,5-diMethylpyrazine, 97+%

3-Chloro-2,5-diMethylpyrazine 98%

3-Chloro-2,5-dimethylpyrazine &gt

3-CHLORO-2,5-DIMETHYLPYRAZINE ISO 9001：2015 REACH

3-Chloro-2,5-dimethylpyrazine,93%

95-89-6

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