3-CHLORO-2,5-DIMETHYLPYRAZINE
- Product Name
- 3-CHLORO-2,5-DIMETHYLPYRAZINE
- CAS No.
- 95-89-6
- Chemical Name
- 3-CHLORO-2,5-DIMETHYLPYRAZINE
- Synonyms
- 3-CHLORO-2,5-DIMETHYLPIAZINE;2,5-Dimethyl-3-chloropyrazine;3-CHLORO-2,5-DIMETHYLPYRAZINE;Pyrazine, 3-chloro-2,5-dimethyl-;3-CHLORO-2,5-DIMETHYL-1,4-DIAZINE;3-Chloro-2,5-dimethylpyrazine,93%;3-Chloro-2,5-dimethylpyrazine >3-Chloro-2,5-diMethylpyrazine 98%;3-Chloro-2,5-diMethylpyrazine, 97+%;3-CHLORO-2,5-DIMETHYLPYRAZINE ISO 9001：2015 REACH
- CBNumber
- CB0176239
- Molecular Formula
- C6H7ClN2
- Formula Weight
- 142.59
- MOL File
- 95-89-6.mol
3-CHLORO-2,5-DIMETHYLPYRAZINE Property
- Boiling point:
- 66-69 °C/9 mmHg (lit.)
- Density
- 1.181 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.527(lit.)
- Flash point:
- 182 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- clear liquid
- pka
- -0.11±0.10(Predicted)
- color
- Colorless to Light orange to Yellow
- InChIKey
- NNBALVIZMGWZHS-UHFFFAOYSA-N
- CAS DataBase Reference
- 95-89-6(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- UQ2462000
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C38400
- Product name
- 3-Chloro-2,5-dimethylpyrazine
- Purity
- 98%
- Packaging
- 25g
- Price
- $74.6
- Updated
- 2023/06/20
- Product number
- C2040
- Product name
- 3-Chloro-2,5-dimethylpyrazine
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $104
- Updated
- 2025/07/31
- Product number
- C365855
- Product name
- 3-Chloro-2,5-dimethylpyrazine
- Packaging
- 100g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- FC42536
- Product name
- 3-Chloro-2,5-dimethylpyrazine
- Packaging
- 25g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FC42536
- Product name
- 3-Chloro-2,5-dimethylpyrazine
- Packaging
- 50g
- Price
- $500
- Updated
- 2021/12/16
3-CHLORO-2,5-DIMETHYLPYRAZINE Chemical Properties,Usage,Production
Chemical Properties
Brown liquid
Uses
3-Chloro-2,5-dimethylpyrazine participates in cross-coupling reactions involving chlroropyrazines with 1-substituted indoles. Occasionally this reaction is catalyzed by iron.
Synthesis
6890-37-5
95-89-6
General procedure for the synthesis of 3-chloro-2,5-dimethylpyrazine from 2,5-dimethylpyrazine 1-oxide: 2,5-dimethylpyrazine 1-oxide (7,15.0 g, 121 mmol) and phosphorous trichloride (POCl3, 55.1 g, 360 mmol) were mixed, and the mixture was stirred and heated for 30 min at 60 °C. (Note: Caution is required during handling, as there have been reports of explosions during mixing). Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured in batches into ice water. The pH was adjusted to alkaline with 20% aqueous sodium hydroxide (NaOH) and then extracted with ether (Et2O). The organic phase was washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. Distillation of the residue gave 12.2 g (71% yield) of 3-chloro-2,5-dimethylpyrazine as a light yellow oil with a boiling point of 98-100 °C/40 Torr. Its infrared spectrum (νmax, membrane method) showed characteristic absorption peaks: 3045 (w), 2999 (w), 2962 (w), 2925 (w), 1567 (w), 1519 ( w), 1454 (s), 1377 (m), 1329 (s), 1313 (s), 1248 (m), 1168 (m), 1088 (s), 968 (m), 456 (m) cm-1. NMR hydrogen spectrum (δH, CDCl3): 2.49 (3H, s), 2.59 (3H, s), 8.23 (1H, s); NMR carbon spectrum (δC, CDCl3): 21.2,22.3,142.1,148.3,150.1,151.7.
References
[1] European Journal of Organic Chemistry, 2010, # 14, p. 2687 - 2695
[2] Tetrahedron, 2017, vol. 73, # 32, p. 4766 - 4769
[3] Organic Letters, 2012, vol. 14, # 10, p. 2576 - 2578
[4] Journal of the American Chemical Society, 1951, vol. 73, p. 2949
[5] Journal of the Chemical Society, 1947, p. 1183
3-CHLORO-2,5-DIMETHYLPYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-2,5-DIMETHYLPYRAZINE Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from 3-CHLORO-2,5-DIMETHYLPYRAZINE manufacturers
- Product
- 3-CHLORO-2,5-DIMETHYLPYRAZINE 95-89-6
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-16
- Product
- 3-CHLORO-2,5-DIMETHYLPYRAZINE 95-89-6
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-05
- Product
- 3-Chloro-2,5-dimethylpyrazine 95-89-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18