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Sodium formaldehydesulfoxylate dihydrate

Product Name
Sodium formaldehydesulfoxylate dihydrate
CAS No.
6035-47-8
Chemical Name
Sodium formaldehydesulfoxylate dihydrate
Synonyms
RONGALITE;SODIUM FORMALDEHYDE SULFOXYLATE;SODIUM FORMALDEHYDE SULPHOXYLATE;SODIUM HYDROXYMETHANESULFINATE DIHYDRATE;RONGALITE C;SODIUM FORMALDEHYDESULFOXALATE;RONGALIT;SODIUM HYDROXYMETHYLSULFINATE;Sodium sulfinomethanolate dihydrate;HYDROXYMETHANESULFINIC ACID SODIUM SALT
CBNumber
CB0853952
Molecular Formula
CH7NaO4S
Formula Weight
138.11
MOL File
6035-47-8.mol
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Sodium formaldehydesulfoxylate dihydrate Property

Melting point:
64-68 °C(lit.)
Density 
1.8 g/cm3 (20℃)
vapor pressure 
2.68 hPa (20 °C)
storage temp. 
Store below +30°C.
solubility 
alcohol: slightly soluble(lit.)
form 
powder to crystal
color 
White to Almost white
PH
9.5-10.5 (100g/l, H2O, 20℃)
CAS DataBase Reference
6035-47-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
31-68
Safety Statements 
24/25-36/37
WGK Germany 
3
RTECS 
PB0390000
HS Code 
28311000
Toxicity
LD50 orally in Rabbit: 6400 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.06455
Product name
Sodium formaldehydesulfoxylate hydrate
Purity
(stabilisedwithsodiumcarbonate)forsynthesis
Packaging
100g
Price
$35.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.06455
Product name
Sodium formaldehydesulfoxylate hydrate
Purity
(stabilisedwithsodiumcarbonate)forsynthesis
Packaging
1kg
Price
$53
Updated
2024/03/01
Sigma-Aldrich
Product number
8.06455
Product name
Sodium formaldehydesulfoxylate hydrate
Purity
(stabilisedwithsodiumcarbonate)forsynthesis
Packaging
5kg
Price
$263
Updated
2024/03/01
Sigma-Aldrich
Product number
8.06455
Product name
Sodium formaldehydesulfoxylate hydrate
Purity
(stabilisedwithsodiumcarbonate)forsynthesis
Packaging
25kg
Price
$476
Updated
2024/03/01
Sigma-Aldrich
Product number
8.06455
Product name
Sodium formaldehydesulfoxylate hydrate
Purity
(stabilisedwithsodiumcarbonate)forsynthesis
Packaging
50kg
Price
$928
Updated
2024/03/01
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Sodium formaldehydesulfoxylate dihydrate Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Chemical Properties

When freshly prepared, sodium formaldehyde sulfoxylate occurs as white, odorless crystals, which quickly develop a characteristic garlic odor on standing.

Uses

Pharmaceutic aid (preservative).

Uses

Sodium hydroxymethanesulfinate dihydrate is a versatile reagent that can be used for a wide range of organic transformations such as:

  • A SO2-2anion source for the preparation of sulfones and sultines.
  • Debromination of vicinal dibromoalkanes.
  • Reductive dehalogenation of aldehydes and ketones.

Production Methods

Sodium formaldehyde sulfoxylate is manufactured from sodium dithionate and formaldehyde in water.

General Description

Oxidation reation of hydroxymethanesulfinic acid with chlorite has been studied in the pH range 4-8. It is a sulfur-containing reducing agent.

Pharmaceutical Applications

Sodium formaldehyde sulfoxylate is a water-soluble antioxidant and is generally used as the dihydrate. It is used in the formulation of injection products at a level of up to 0.1% w/v in the final preparation administered to the patient.

Safety

The toxicological properties of sodium formaldehyde sulfoxylate have not been fully investigated. However, it is used in the formulation of injection products at a level to 0.1% w/v in the final preparation administered to the patient.
Sodium formaldehyde sulfoxylate is moderately toxic by ingestion, and when heated to decomposition it emits toxic fumes of sulfur dioxide and sodium oxide.
LD50 (mouse, oral): 4 g/kg
LD50 (rat, IP): >2 g/kg
LD50 (rat, oral): >2 g/kg

storage

Store in well-closed, light-resistant containers at controlled room temperature (15–30℃).

Incompatibilities

Sodium formaldehyde sulfoxylate is incompatible with strong oxidizing agents; it is decomposed by dilute acid.

Regulatory Status

Included in the FDA Inactive Ingredients Database (parenteral products up to 0.1% via the IM, IV, and SC routes). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium formaldehydesulfoxylate dihydrate Preparation Products And Raw materials

Raw materials

ZINC HYDROSULFITE

Preparation Products

Neoarsphenamine microdispersoid acrylate resin filling emulsion
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Sodium formaldehydesulfoxylate dihydrate Suppliers

Belgium 1 China 152 Europe 2 France 1 Germany 3 India 9 Japan 3 Switzerland 1 United Kingdom 4 United States 20 Global 196
shandongxinheng
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15269160605 15269160605
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Tianjin heowns Biochemical Technology Co., Ltd.
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Sinopharm Chemical Reagent Co,Ltd.
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Maya High Purity Chemicals
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+86 (573) 82222445 (0)18006601000 452520369
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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ShangHai YuanYe Biotechnology Co., Ltd.
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Chengdu Ai Keda Chemical Technology Co., Ltd.
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4008-755-333 18080918076
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View Lastest Price from Sodium formaldehydesulfoxylate dihydrate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Sodium formaldehydesulfoxylate dihydrate 6035-47-8
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-12-19
Hebei Weibang Biotechnology Co., Ltd
Product
Sodium formaldehydesulfoxylate dihydrate 6035-47-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-15
Henan Fengda Chemical Co., Ltd
Product
Sodium formaldehydesulfoxylate dihydrate 6035-47-8
Price
US $8.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-03

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