Temoporfin
- Product Name
- Temoporfin
- CAS No.
- 122341-38-2
- Chemical Name
- Temoporfin
- Synonyms
- EF 9;MTHPC;Foslip;Fosgel;Foscan;Fospeg;KW2345;Foslipos;m-TrTHPC;temoporfin
- CBNumber
- CB0855310
- Molecular Formula
- C44H32N4O4
- Formula Weight
- 680.75
- MOL File
- 122341-38-2.mol
Temoporfin Property
- Melting point:
- >250 °C
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Purple
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17333
- Product name
- Temoporfin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17333
- Product name
- Temoporfin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 17333
- Product name
- Temoporfin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 17333
- Product name
- Temoporfin
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- T017350
- Product name
- Temoporfin,~90%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
Temoporfin Chemical Properties,Usage,Production
Description
Temoporphin, a second generation photosensitizer, was launched in UK for the photodynamic therapy (PDT) of advanced head and neck cancers. This porphyrin derivative can be synthesized from pyrrole and 3-hydroxybenzaldehyde. The pharmacological activity is initiated, 4 days after intravenous injection, by laser-light photoactivation of temoporphin, that has selectively accumulated in cancer tissues. The resulting generation of highly reactive oxygen species leads to malignant cells death thereby inducing tumor necrosis up to a depth of 15 mm. An advantage of temoporphin over other photosensitizing agents is its extreme sensitivity to wavelengths of light that penetrate tissues, resulting in lower light/dose and irradiation time. PDT with intravenous temoporphin has produced relatively high complete and partial response rates in head and neck cancers, with higher response rates generally observed with higher light dose. Temoporphin is well-tolerated and does not preclude surgery/radiotherapy as a later option. Adverse effects were photosensitivity and pain at the injection site.
Originator
Quanta Nova (UK)
Uses
Temoporfin is a synthetic chlorin with light-activated actions. It accumulates in tumor cells and through light activation and oxygen radical formation, it leads to necrosis and cell death.
Uses
Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells. When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor. Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.
Definition
ChEBI: Temoporfin is a member of chlorins. It has a role as a photosensitizing agent.
brand name
Foscan
Temoporfin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Temoporfin manufacturers
- Product
- Temoporfin 122341-38-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06
- Product
- Temoporfin 122341-38-2
- Price
- US $3.00/ASSAYS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09