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Temoporfin

Product Name
Temoporfin
CAS No.
122341-38-2
Chemical Name
Temoporfin
Synonyms
EF 9;MTHPC;Foslip;Fosgel;Foscan;Fospeg;KW2345;Foslipos;m-TrTHPC;temoporfin
CBNumber
CB0855310
Molecular Formula
C44H32N4O4
Formula Weight
680.75
MOL File
122341-38-2.mol
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Temoporfin Property

Melting point:
>250 °C
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Purple
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17333
Product name
Temoporfin
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17333
Product name
Temoporfin
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
17333
Product name
Temoporfin
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
17333
Product name
Temoporfin
Purity
≥95%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
T017350
Product name
Temoporfin,~90%
Packaging
5mg
Price
$110
Updated
2021/12/16
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Temoporfin Chemical Properties,Usage,Production

Description

Temoporphin, a second generation photosensitizer, was launched in UK for the photodynamic therapy (PDT) of advanced head and neck cancers. This porphyrin derivative can be synthesized from pyrrole and 3-hydroxybenzaldehyde. The pharmacological activity is initiated, 4 days after intravenous injection, by laser-light photoactivation of temoporphin, that has selectively accumulated in cancer tissues. The resulting generation of highly reactive oxygen species leads to malignant cells death thereby inducing tumor necrosis up to a depth of 15 mm. An advantage of temoporphin over other photosensitizing agents is its extreme sensitivity to wavelengths of light that penetrate tissues, resulting in lower light/dose and irradiation time. PDT with intravenous temoporphin has produced relatively high complete and partial response rates in head and neck cancers, with higher response rates generally observed with higher light dose. Temoporphin is well-tolerated and does not preclude surgery/radiotherapy as a later option. Adverse effects were photosensitivity and pain at the injection site.

Originator

Quanta Nova (UK)

Uses

Temoporfin is a synthetic chlorin with light-activated actions. It accumulates in tumor cells and through light activation and oxygen radical formation, it leads to necrosis and cell death.

Uses

Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells. When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor. Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.

Definition

ChEBI: Temoporfin is a member of chlorins. It has a role as a photosensitizing agent.

brand name

Foscan

Temoporfin Preparation Products And Raw materials

Raw materials

Preparation Products

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Temoporfin Suppliers

China 80 India 3 United States 14 Global 97
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
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View Lastest Price from Temoporfin manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Temoporfin 122341-38-2
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-06
Career Henan Chemical Co
Product
Temoporfin 122341-38-2
Price
US $3.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-09

122341-38-2, TemoporfinRelated Search:

Temozolomide POLYPYRROLE Phthalocyanine CHLORIN E6 TPP monoaspartyl chlorin e6 PORPHINE ETHYL-BIS-(SODIUMTETRAZOYLAZO)ACETATE Hydroxyphenyl temoporfin-polyethylene glycol conjugate Temoporfin

  • TeMoporfin(KW-2345,EF9)
  • EF 9
  • Foscan
  • Fosgel
  • Foslip
  • Foslipos
  • Fospeg
  • MTHPC
  • 2, 3-dihydro-5,10,15,20-tetra(m-hydroxyphenyl)porphyrin
  • 3,3',3'',3'''-(2,3-dihydroporphyrin -5,10,15,20-tetrayl) tetraphenol
  • 5,10,15,20-tetra(hydroxyphenyl)chlorin
  • m-TrTHPC
  • Temoporphin
  • Temoporfin (m-THPC)
  • temoporfin
  • 8-dihydroporphyrin-5
  • 5,10,15,20-tetra(m-hydroxyphenyl)chlorin
  • 3,3',3'',3'''-(7,8-dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol
  • Phenol,3,3',3'',3'''-(7,8-dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-
  • Temoporfin(KW-2345)
  • KW2345
  • 3,3',3'',3'''-(7H,8H-Porphyrin-5,10,15,20-tetrayl)tetraphenol
  • 3,3',3'',3'''-(7H,8H-Porphyrin-5,10,15,20-tetrayl)tetraphenol
  • 122341-38-2
  • C44H32N4O4