ChemicalBook > CAS DataBase List > 3-Methyl-6-nitroindazole

3-Methyl-6-nitroindazole

Product Name
3-Methyl-6-nitroindazole
CAS No.
6494-19-5
Chemical Name
3-Methyl-6-nitroindazole
Synonyms
-6-nitro-1H-indazoL;3-Methyl-6-Nitro-1H-;Pazopanib Impurity 49;3-Methyl-6-nitroindole;6-Nitro-3-Methylindazole;3-Methyl-6-nitroindazole;3-Methyl-6-Nitro-1h-Indole;3-Methyl-6-nitroindazole>3-Methyl-6-nitro-2H-indazole;3-METHYL-6-NIFRO-1H-INDAZOLE
CBNumber
CB0855330
Molecular Formula
C8H7N3O2
Formula Weight
177.16
MOL File
6494-19-5.mol
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3-Methyl-6-nitroindazole Property

Melting point:
187-188°C
Boiling point:
384.9±22.0 °C(Predicted)
Density 
1.437
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
11.47±0.40(Predicted)
color 
Beige to Dark Yellow
InChI
InChI=1S/C8H7N3O2/c1-5-7-3-2-6(11(12)13)4-8(7)10-9-5/h2-4H,1H3,(H,9,10)
InChIKey
FUNWSYKLFDLUIZ-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC([N+]([O-])=O)=C2)C(C)=N1
CAS DataBase Reference
6494-19-5
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Safety

Risk Statements 
20/21/22
Safety Statements 
24/25-36/37
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2358
Product name
3-Methyl-6-nitroindazole
Purity
>98.0%(GC)
Packaging
5g
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
M2358
Product name
3-Methyl-6-nitroindazole
Purity
>98.0%(GC)
Packaging
25g
Price
$95
Updated
2024/03/01
TRC
Product number
M325555
Product name
3-Methyl-6-nitroindazole
Packaging
10g
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0002013
Product name
3-METHYL-6-NITROINDAZOLE
Purity
95.00%
Packaging
5MG
Price
$500.74
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
47598
Product name
3-Methyl-6-nitroindazole
Packaging
1g
Price
$625
Updated
2021/12/16
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3-Methyl-6-nitroindazole Chemical Properties,Usage,Production

Description

3-Methyl-6-nitroindazole is an important organic reagent or pharmaceutical intermediate compound used in the preparation of key intermediates of pazopanib. In experimental studies, it is mostly used for solubility determination, correlation and molecular interaction analysis studies in different pure and mixed solvents. The results showed that in the temperature range of (278.15 ~ 328.15)K, the molar fraction solubility of 3-Methyl-6-nitroindazole increased with increasing temperature in both pure and mixed solvent systems, and was maximum in pure N, N-dimethylformamide and minimum in water.

Chemical Properties

Brown solid

Uses

3-Methyl-6-nitroindazole a reactant used in the preparation of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

References

[1] Li, Wanxin et al. “3-Methyl-6-nitroindazole in some aqueous co-solvent mixtures: Solubility determination, preferential solvation and solvent effect analysis.” The Journal of Chemical Thermodynamics 34 1 (2020): 0.
[2] Li Wang. “Solubility Measurement, Correlation, and Molecular Interactions of 3-Methyl-6-nitroindazole in Different Neat Solvents and Mixed Solvents from T = 278.15 to 328.15 K.” Journal of Chemical & Engineering Data 64 8 (2019): 3260–3269.

Physical properties

3-Methyl-6-nitroindazole, a slightly yellow to tawny powder with a molecular weight of 177.16, is one critical intermediate of Pazopanib. The chemical structure of 3-methyl-6-nitroindazole is shown below. Wang et al. measured the solubility of 3-methyl-6-nitroindazole in eight pure solvents [i.e., N, N-dimethylformamide (DMF), tetrahydrofuran (THF), acetone, ethyl acetate (EA), ethanol, acetonitrile, n-propanol, water] and three mixed solvents (DMF + water, THF + cyclohexane, acetone + water) at temperatures T = 278.15 to 328.15 K and under atmosphere pressure. Whether in a pure solvent or a mixed system, the results show that mole fraction solubilities of 3-methyl-6-nitroindazole increased with increasing temperature. Among the three groups of mixed solvents measured, the molar fraction of 3-methyl-6-nitroindazole in the (DMF + water) system is the maximum[1-2].

3-Methyl-6-nitroindazole Preparation Products And Raw materials

Raw materials

2-ethyl-5-nitroaniline 2-Ethylaniline Sodium nitrite Nitric acid Acetic acid Sulfuric acid

Preparation Products

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View Lastest Price from 3-Methyl-6-nitroindazole manufacturers

Henan Fengda Chemical Co., Ltd
Product
3-Methyl-6-nitroindazole 6494-19-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16
Guangzhou Sunton Biotechnology Co., Ltd.
Product
3-methyl-6-nitro-1H-indazole 6494-19-5
Price
US $50.00-30.00/ASSAYS
Min. Order
1化验
Purity
99.%
Supply Ability
2 tons
Release date
2021-06-04
Career Henan Chemical Co
Product
3-Methyl-6-nitroindazole 6494-19-5
Price
US $20.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2018-07-27

6494-19-5, 3-Methyl-6-nitroindazoleRelated Search:

Methylparaben Tolyltriazole METSULFURON METHYL Methyl acrylate 1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE Bensulfuron methyl Kresoxim-methyl 5-Methyl-1H-benzotriazole Methanol Methyl cellulose 6-Nitroindazole Methyl 2-Ethyl-5-nitrobenzenamine ,98% 5-Amino-2-methylbenzenesulfonamide N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine Pazopanib Impurity 48 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole

  • 3-Methyl-6-nitroindole
  • 3-Methyl-6-Nitro-1h-Indole
  • 3-METHYL-6-NITRO-1H-INDOZOLE
  • 3-METHYL-6-NIFRO-1H-INDAZOLE
  • 3-Methyl-6-nitro-2H-indazole
  • 3-METHYL-6-NIFRO-1H-INDAZOLE,99+%
  • 3-Methyl-6-nitro-1H-indazole ,97%
  • 3-Methyl-6-nitro-1H-indaz...
  • 1H-Indazole, 3-Methyl-6-nitro-
  • 3-Methyl-6-Nitro-1H-
  • 6-Nitro-3-Methylindazole
  • 3-Methyl-6-nitro-1H-indazole≥ 99% (HPLC)
  • 3-methyl-6-nitro-1h-indazole
  • 3-Methyl-6-nitroindazole
  • 3-Methyl-6-nitro-1h-indazole 99%
  • 3-Methyl-6-nitroindazole&gt
  • Pazopanib Impurity 49
  • -6-nitro-1H-indazoL
  • methyl 5-amino-2-methylbenzenesulfonate
  • 6494-19-5
  • 6494-19-6
  • Heterocyclic Compound
  • Indole