(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one

Product Name: (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one
CAS No.: 139226-28-1
Chemical Name: (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one
Synonyms: CS-490;darbufelone;Darbufelone, 10 mM in DMSO;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl);(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylide...;(Z)-2-AMino-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one;5-((z)-3,5-di-tert-butyl-4-hydroxybenzylidene)-2-imino-4-thiazolidinone;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one;(5z)-2-amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one;4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)-
CBNumber: CB0855486
Molecular Formula: C18H24N2O2S
Formula Weight: 332.46
MOL File: 139226-28-1.mol

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(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Property

Boiling point:: 448.6±55.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 9.98±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0021331
Product name: Darbufelone
Purity: >98.0%
Packaging: 1mg
Price: $240
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005639
Product name: DARBUFELONE
Purity: 95.00%
Packaging: 5MG
Price: $505.07
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005639
Product name: DARBUFELONE
Purity: 95.00%
Packaging: 100MG
Price: $2047.5
Updated: 2021/12/16

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(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Chemical Properties,Usage,Production

Biological Activity

Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. It potently inhibits PGHS-2 (IC50=0.19 μM), but is much less potent against PGHS-1 (IC50=20 μM).

in vivo

Darbufelone is a dual inhibitor of cellular PGF2R and LTB4 production. Darbufelone is orally active and nonulcerogenic in animal models of inflammation and arthritis.

target

IC50: 0.19 μM (PGHS-2), 20 μM (PGHS-1)

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Suppliers

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139226-28-1, (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-oneRelated Search:

Phenol Thiazole DARBUFELONE MESILATE (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one

(5z)-2-amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one

5-((z)-3,5-di-tert-butyl-4-hydroxybenzylidene)-2-imino-4-thiazolidinone

(Z)-2-AMino-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one

darbufelone

CS-490

(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one

4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)-

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylide...

(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)

Darbufelone, 10 mM in DMSO

139226-28-1