Isoconazole
- Product Name
- Isoconazole
- CAS No.
- 27523-40-6
- Chemical Name
- Isoconazole
- Synonyms
- Isoconazol;soconazole;Isoconazole CRS;Einecs 248-508-3;Miconazole EP IMP D;24168-96-5 (Nitrate);Miconazole Impurity D;Isoconazole USP/EP/BP;Isoconazol [inn-spanish];Miconazole EP Impurity D
- CBNumber
- CB0875200
- Molecular Formula
- C18H14Cl4N2O
- Formula Weight
- 416.13
- MOL File
- 27523-40-6.mol
Isoconazole Property
- Boiling point:
- 555.1±50.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent).
- pka
- 6?+-.0.12(Predicted)
- CAS DataBase Reference
- 27523-40-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I0375000
- Product name
- Isoconazole
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- i0375000
- Price
- $220
- Updated
- 2024/03/01
- Product number
- API0007221
- Product name
- ISOCONAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $544.5
- Updated
- 2021/12/16
- Product number
- API0007221
- Product name
- ISOCONAZOLE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $939.75
- Updated
- 2021/12/16
Isoconazole Chemical Properties,Usage,Production
Chemical Properties
White or almost white powder.
Originator
Fazol,Fournier,France,1979
Uses
Antibacterial; antifungal.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, isoconazole is indicated for therapy of vulvovaginal mycoses causes by Candida species and Candida (Torulopsis) glabrata.
Definition
ChEBI: 1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1. It is a dichlorobenzene, an ether and a member of imidazoles.
Manufacturing Process
To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.
Therapeutic Function
Antibacterial, Antifungal
Antimicrobial activity
Broad-spectrum azole antimycotic with activity against almost all species of pathogenic fungi.
Pharmacokinetics
After topical application, isoconazole remains practically unabsorbed. Application in an ethanol/propyleneglycol vehicle increases penetration into the stratum corneum of the skin significantly.
Side effects
Local irritations such as itching and burning sensations and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.
Solubility in organics
Isoconazole is soluble in methanol, acetic acid, and PEG 400; less soluble in ethanol, acetone, chloroform, and butanol; and barely soluble in water, diethyl ether, cyclohexane, and hexane.
Isoconazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isoconazole manufacturers
- Product
- Isoconazole 27523-40-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-19
- Product
- Isoconazole 27523-40-6
- Price
- US $0.01-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2020-05-12