Uniprofen
- Product Name
- Uniprofen
- CAS No.
- 51234-28-7
- Chemical Name
- Uniprofen
- Synonyms
- Opren;Coxigon;Oraflex;Inflamid;LY-90459;Uniprofen;LRCL-3794;NSC 299582;Aids128826;Lilly-90459
- CBNumber
- CB0875361
- Molecular Formula
- C16H12ClNO3
- Formula Weight
- 301.73
- MOL File
- 51234-28-7.mol
Uniprofen Property
- Melting point:
- 189.5°C
- Boiling point:
- 446.2±30.0 °C(Predicted)
- Density
- 1.2411 (rough estimate)
- refractive index
- 1.6470 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO: slightly; Methanol: slightly, sonicated
- form
- A solid
- pka
- 4.36±0.30(Predicted)
- color
- Cream solid from EtOH
Safety
- Toxicity
- LD50 oral in rat: 118mg/kg
N-Bromosuccinimide Price
- Product number
- B165300
- Product name
- Benoxaprofen
- Packaging
- 10mg
- Price
- $470
- Updated
- 2021/12/16
- Product number
- API0007668
- Product name
- BENOXAPROFEN
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $1045.28
- Updated
- 2021/12/16
- Product number
- API0007668
- Product name
- BENOXAPROFEN
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $4331.25
- Updated
- 2021/12/16
- Product number
- API0007668
- Product name
- BENOXAPROFEN
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $329.7
- Updated
- 2021/12/16
Uniprofen Chemical Properties,Usage,Production
Originator
Opren,Dista Lilly,UK,1980
Uses
A non-steroidal anti-inflammatory ophthalmic agent.
Definition
ChEBI: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects inc uding liver necrosis, photosensitivity, and carcinogenicity in animals.
Manufacturing Process
The 6-benzoxazolyl analog of the 5-benzoxazolyl product is prepared as
follows:
(a) Ethyl 2-(2-p-chlorophenyl-6-benzoxazolyl)propionate: A solution of ethyl
2-(3-hydroxy-4-aminophenyl)propionate (2.5 g) in pyridine (15 ml) was
treated with p-chlorobenzoyl chloride (1.65 ml) at 5°C. After stirring for 2
hours at room temperature the solution was evaporated to dryness.
The residue was heated at 220°C until no more water was evolved, then was
allowed to cool. This yielded ethyl 2-(2-p-Chlorophenyl-6-
benzoxazolyl)propionate.
(b) 2-(2-p-Chlorophenyl-6-benzoxazolyl)propionic acid: A solution of ethyl 2-
(2-chlorophenyl-6-benzoxazolyl)propionate (4 g) in aqueous sodium hydroxide
(30 ml) was heated on a steam bath for one-half hour. On cooling the black
solution was washed with chloroform. On acidification of the black solution
with hydrochloric acid the mixture was extracted with chloroform. This
solution on evaporation yielded 2-(2-p-chlorophenyl-6-benzoxazolyl)propionic
acid, MP 196°C.
brand name
Oraflex (Lilly);90459 compound;Benoxapran;Bexopron;Compound 90459;Lilly 3794;Lilly 90459;Lrcl 3794;Oprenal.
Therapeutic Function
Antiinflammatory, Analgesic
World Health Organization (WHO)
Benoxaprofen, a nonsteroidal antiinflammatory agent, was introduced in 1980 for the treatment of rheumatic disorders. Following reports of serious adverse effects, some of which were fatal, it was withdrawn in several countries prior to worldwide withdrawal by the manufacturer in 1982.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. Moderately toxic to humans by ingestion.Human systemic effects by ingestion: jaundice and gynecomastia (excessive development of the male mammary glands), changes in kidney tubules, decreased
Uniprofen Preparation Products And Raw materials
Raw materials
Preparation Products
Uniprofen Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94657
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9648
- Advantage
- 58
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4891
- Advantage
- 55
- Tel
- 0512-0512-63009836 15365350169
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3984
- Advantage
- 60
- Tel
- 18086626237 18086626237
- Fax
- qq:2693528373
- sales@debyesci.com
- Country
- China
- ProdList
- 2645
- Advantage
- 56
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 7296
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58