Uniprofen

Product Name: Uniprofen
CAS No.: 51234-28-7
Chemical Name: Uniprofen
Synonyms: Opren;Coxigon;Oraflex;Inflamid;LY-90459;Uniprofen;LRCL-3794;NSC 299582;Aids128826;Lilly-90459
CBNumber: CB0875361
Molecular Formula: C16H12ClNO3
Formula Weight: 301.73
MOL File: 51234-28-7.mol

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Uniprofen Property

Melting point:: 189.5°C
Boiling point:: 446.2±30.0 °C(Predicted)
Density: 1.2411 (rough estimate)
refractive index: 1.6470 (estimate)
storage temp.: Refrigerator
solubility: DMSO: slightly; Methanol: slightly, sonicated
form: A solid
pka: 4.36±0.30(Predicted)
color: Cream solid from EtOH

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Safety

Toxicity: LD50 oral in rat: 118mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

TRC

Product number: B165300
Product name: Benoxaprofen
Packaging: 10mg
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007668
Product name: BENOXAPROFEN
Purity: 95.00%
Packaging: 10MG
Price: $1045.28
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007668
Product name: BENOXAPROFEN
Purity: 95.00%
Packaging: 100MG
Price: $4331.25
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007668
Product name: BENOXAPROFEN
Purity: 95.00%
Packaging: 1MG
Price: $329.7
Updated: 2021/12/16

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Uniprofen Chemical Properties,Usage,Production

Originator

Opren,Dista Lilly,UK,1980

Uses

A non-steroidal anti-inflammatory ophthalmic agent.

Definition

ChEBI: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects inc uding liver necrosis, photosensitivity, and carcinogenicity in animals.

Manufacturing Process

The 6-benzoxazolyl analog of the 5-benzoxazolyl product is prepared as follows:
(a) Ethyl 2-(2-p-chlorophenyl-6-benzoxazolyl)propionate: A solution of ethyl 2-(3-hydroxy-4-aminophenyl)propionate (2.5 g) in pyridine (15 ml) was treated with p-chlorobenzoyl chloride (1.65 ml) at 5°C. After stirring for 2 hours at room temperature the solution was evaporated to dryness.
The residue was heated at 220°C until no more water was evolved, then was allowed to cool. This yielded ethyl 2-(2-p-Chlorophenyl-6- benzoxazolyl)propionate.
(b) 2-(2-p-Chlorophenyl-6-benzoxazolyl)propionic acid: A solution of ethyl 2- (2-chlorophenyl-6-benzoxazolyl)propionate (4 g) in aqueous sodium hydroxide (30 ml) was heated on a steam bath for one-half hour. On cooling the black solution was washed with chloroform. On acidification of the black solution with hydrochloric acid the mixture was extracted with chloroform. This solution on evaporation yielded 2-(2-p-chlorophenyl-6-benzoxazolyl)propionic acid, MP 196°C.

brand name

Oraflex (Lilly);90459 compound;Benoxapran;Bexopron;Compound 90459;Lilly 3794;Lilly 90459;Lrcl 3794;Oprenal.

Therapeutic Function

Antiinflammatory, Analgesic

World Health Organization (WHO)

Benoxaprofen, a nonsteroidal antiinflammatory agent, was introduced in 1980 for the treatment of rheumatic disorders. Following reports of serious adverse effects, some of which were fatal, it was withdrawn in several countries prior to worldwide withdrawal by the manufacturer in 1982.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Moderately toxic to humans by ingestion.Human systemic effects by ingestion: jaundice and gynecomastia (excessive development of the male mammary glands), changes in kidney tubules, decreased

Uniprofen Preparation Products And Raw materials

Raw materials

Preparation Products

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Uniprofen Suppliers

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51234-28-7, UniprofenRelated Search:

Quinclorac 2-(4-CHLORO-PHENYL)-BENZOOXAZOLE Uniprofen

Coxigon

Opren

Oraflex

Uniprofen

2-(2-(4-chlorophenyl)benzo[d]oxazol-5-yl)propanoic acid

2-[2-(4-Chlorophenyl)benzoxazol-5-yl]-propanoic Acid

dl-Benoxaprofen

NSC 299582

2-(4-Chlorophenyl)-α-methyl-5-benzoxazoleacetic acid

Compound-90459

Lilly-90459

LRCL-3794

2-(2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl)propanoic acid

2-(p-Chlorophenyl)-.alpha.-methyl-5-benzoxazoleacetic acid

5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-.alpha.-methyl-

Aids128826

Aids-128826

Inflamid

2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid

5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-α-methyl-

Benoxaphen. Compound 90459

LY-90459

4H-1-Benzopyran-4-one,7-hydroxy-3-(trifluoromethyl)-

inflammation,LRCL-3794,monocyte migration,inhibit,COX,Cyclooxygenase,LRCL 3794,LRCL3794,Inhibitor,lipoxygenase,Benoxaprofen,antipyretic compound

2-[2-(4-Chlorophenyl)-5-benzoxazolyl]propanoic Acid

51234-28-7

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