clofedanol

Product Name: clofedanol
CAS No.: 791-35-5
Chemical Name: clofedanol
Synonyms: Dencyl;clofedano;Tussistop;clofedanol;Calmotusin;NSC 113595;Chlofedanol;Clophedianol;CHLOPHENDIANOL;Clophedianol base
CBNumber: CB0875699
Molecular Formula: C17H20ClNO
Formula Weight: 289.7998
MOL File: 791-35-5.mol

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clofedanol Property

Melting point:: 120°
Boiling point:: 429.8±45.0 °C(Predicted)
Density: 1.148±0.06 g/cm3(Predicted)
pka: 13.03±0.29(Predicted)
CAS DataBase Reference: 791-35-5

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Safety

Toxicity: LD50 i.v. in mice: 70 mg/kg (Lorenz)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

IsoSciences

Product number: 13420
Product name: Chlophedianol-[13C6]
Purity: ≥98%
Packaging: 1mg
Price: $217
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009164
Product name: CHLOPHEDIANOL
Purity: 95.00%
Packaging: 250MG
Price: $727.65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009164
Product name: CHLOPHEDIANOL
Purity: 95.00%
Packaging: 1G
Price: $825.3
Updated: 2021/12/16

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clofedanol Chemical Properties,Usage,Production

Originator

Detigon,Bayer,W. Germany,1958

Uses

(±)-Chlophedianol is an inhalation eutectic compound, used for treatment of respiratory diseases.Also, used in preparation of Deuterated morphine derivatives useful in treatment of pain or as as antitussive agents with reduced risk of possibility of drug abuse.

Definition

ChEBI: Clofedanol is a diarylmethane that is 2-chlorophenyl(phenyl)methane substituted on the methane carbon by a 2-(dimethylamino)ethyl group. Used in the treatment of dry cough, it suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain. It has a role as an antitussive. It is a diarylmethane and a tertiary amino compound. It is a conjugate base of a clofedanol(1+).

Manufacturing Process

This compound may be produced by reacting o-chlorobenzophenone with acetonitrile in the presence of sodium amide or another strongly basic condensing agent, to form the nitrile of beta-phenyl-beta-o-chlorophenyl-hydracrylic acid, which is then hydrogenated to yield 1-phenyl-1-o-chlorophenyl-3-aminopropanol-1. The latter intermediate compound is subsequently dimethylated with an agent such as methyl sulfate to provide the desired end product 1-o-chlorophenyl-1-phenyl-3-dimethylaminopropanol.

Therapeutic Function

Antitussive

clofedanol Preparation Products And Raw materials

Raw materials

Preparation Products

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clofedanol Suppliers

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View Lastest Price from clofedanol manufacturers

Career Henan Chemical Co

Product: clofedanol 791-35-5
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-12

791-35-5, clofedanolRelated Search:

Trimethylolpropane Robenidine hydrochloride 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE Dextromethorphan Cimetidine Ranitidine Daptomycin Atropine 3-Dimethylamino-1-propanol

1-(2-chlorophenyl)-3-dimethylamino-1-phenylpropan-1-ol

clofedanol

clofedano

CHLOPHENDIANOL

1-o-Chlorophenyl-1-phenyl-3-dimethylamino-1-propanol

1-o-Chlorophenyl-3-dimethylamino-1-phenylpropan-1-ol

1-Phenyl-1-(o-chlorophenyl)-3-dimethylaminopropanol

1-Phenyl-1-o-chlorophenyl-3-(dimethylamino)-1-propanol

2-Chloro-α-(2-dimethylaminoethyl)benzhydrol

Benzenemethanol, 2-chloro-α-[2-(dimethylamino)ethyl]-α-phenyl-

Benzhydrol, 2-chloro-α-[2-(dimethylamino)ethyl]- (6CI, 7CI, 8CI)

Calmotusin

NSC 113595

Tussistop

α-(Dimethylaminoethyl)-o-chlorobenzhydrol

Chlophedianol (base and/or unspecified salts)

CLOFEDANOL(CHLOPHEDIANOL)

Chlofedanol

.alpha.-(Dimethylaminoethyl)-o-chlorobenzhydrol

2-Chloro-.alpha.-(2-dimethylaminoethyl)benzhydrol

Benzenemethanol, 2-chloro-.alpha.-[2-(dimethylamino)ethyl]-.alpha.-phenyl-

Benzhydrol, 2-chloro-.alpha.-[2-(dimethylamino)ethyl]-

Clophedianol base

Dencyl

Clophedianol

Chlophedianol-13C6

clofedanol USP/EP/BP

791-35-5