clofedanol
- Product Name
- clofedanol
- CAS No.
- 791-35-5
- Chemical Name
- clofedanol
- Synonyms
- Dencyl;clofedano;Tussistop;clofedanol;Calmotusin;NSC 113595;Chlofedanol;Clophedianol;CHLOPHENDIANOL;Clophedianol base
- CBNumber
- CB0875699
- Molecular Formula
- C17H20ClNO
- Formula Weight
- 289.7998
- MOL File
- 791-35-5.mol
clofedanol Property
- Melting point:
- 120°
- Boiling point:
- 429.8±45.0 °C(Predicted)
- Density
- 1.148±0.06 g/cm3(Predicted)
- pka
- 13.03±0.29(Predicted)
- CAS DataBase Reference
- 791-35-5
Safety
- Toxicity
- LD50 i.v. in mice: 70 mg/kg (Lorenz)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 13420
- Product name
- Chlophedianol-[13C6]
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $217
- Updated
- 2021/12/16
- Product number
- API0009164
- Product name
- CHLOPHEDIANOL
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $727.65
- Updated
- 2021/12/16
- Product number
- API0009164
- Product name
- CHLOPHEDIANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $825.3
- Updated
- 2021/12/16
clofedanol Chemical Properties,Usage,Production
Originator
Detigon,Bayer,W. Germany,1958
Uses
(±)-Chlophedianol is an inhalation eutectic compound, used for treatment of respiratory diseases.Also, used in preparation of Deuterated morphine derivatives useful in treatment of pain or as as antitussive agents with reduced risk of possibility of drug abuse.
Definition
ChEBI: Clofedanol is a diarylmethane that is 2-chlorophenyl(phenyl)methane substituted on the methane carbon by a 2-(dimethylamino)ethyl group. Used in the treatment of dry cough, it suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain. It has a role as an antitussive. It is a diarylmethane and a tertiary amino compound. It is a conjugate base of a clofedanol(1+).
Manufacturing Process
This compound may be produced by reacting o-chlorobenzophenone with acetonitrile in the presence of sodium amide or another strongly basic condensing agent, to form the nitrile of beta-phenyl-beta-o-chlorophenyl-hydracrylic acid, which is then hydrogenated to yield 1-phenyl-1-o-chlorophenyl-3-aminopropanol-1. The latter intermediate compound is subsequently dimethylated with an agent such as methyl sulfate to provide the desired end product 1-o-chlorophenyl-1-phenyl-3-dimethylaminopropanol.
Therapeutic Function
Antitussive
clofedanol Preparation Products And Raw materials
Raw materials
Preparation Products
clofedanol Suppliers
View Lastest Price from clofedanol manufacturers
- Product
- clofedanol 791-35-5
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12