1-(4-amino-3-fluorophenyl)ethan-1-one
- Product Name
- 1-(4-amino-3-fluorophenyl)ethan-1-one
- CAS No.
- 73792-22-0
- Chemical Name
- 1-(4-amino-3-fluorophenyl)ethan-1-one
- Synonyms
- 4-Acetyl-2-fluoroaniline;3-Fluoro-4-aminoacetophenone;4’-Amino-3’-fluoroacetophenone;4'-Amino-3'-fluoroacetophenone;1-(4-Amino-3-fluorophenyl)ethanone;1-(4-amino-3-fluorophenyl)ethan-1-one;Ethanone, 1-(4-amino-3-fluorophenyl)-;Ethanone, 1-(4-amino-3-fluorophenyl)- (9CI)
- CBNumber
- CB0883289
- Molecular Formula
- C8H8FNO
- Formula Weight
- 153.15
- MOL File
- 73792-22-0.mol
1-(4-amino-3-fluorophenyl)ethan-1-one Property
- Melting point:
- 86-88℃
- Boiling point:
- 286℃
- Density
- 1.201
- Flash point:
- 127℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 0.77±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A609785
- Product name
- 1-(4-Amino-3-fluorophenyl)ethanone
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- A609785
- Product name
- 1-(4-Amino-3-fluorophenyl)ethanone
- Packaging
- 10g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- A609785
- Product name
- 1-(4-Amino-3-fluorophenyl)ethanone
- Packaging
- 100g
- Price
- $1570
- Updated
- 2021/12/16
- Product number
- X8376
- Product name
- 4'-Amino-3'-fluoroacetophenone
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- X8376
- Product name
- 4'-Amino-3'-fluoroacetophenone
- Packaging
- 5g
- Price
- $127
- Updated
- 2021/12/16
1-(4-amino-3-fluorophenyl)ethan-1-one Chemical Properties,Usage,Production
Uses
1-(4-Amino-3-fluorophenyl)ethanone can be used as a starting material in the preparation of 2-Amino-5-[(cyclopentylamino)acetyl]-3-fluoro-benzonitrile.
Synthesis
111-34-2
29632-74-4
73792-22-0
Example 7: Synthesis of (R)-N-(4-{1-[3-(4-tert-butyl-benzyl)-ureido]-ethyl}-2-fluoro-6-vinyl-phenyl)-methanesulfonamide; Step i: Preparation of 1-(4-amino-3-fluorophenyl)ethanone. In a 25 mL two-necked round-bottomed flask, filled with argon protection, a DMF solution of 2-fluoro-4-iodoaniline (1500 mg, 6.33 mmol) was added. Palladium(II) acetate (42.62 mg, 0.19 mmol), 1,3-bis(diphenylphosphino)propane (156.65 mg, 0.38 mmol, 0.06 equiv.), thallium(I) acetate (1834.19 mg, 6.96 mmol), and butyl vinyl ether (1.64 mL, 12.66 mmol, 2 equiv.) were then added sequentially. The reaction mixture was heated and stirred for 15 hours. After the reaction was completed, the mixture was poured into THF and 10% HCl solution was added slowly. The reaction mixture was extracted with ethyl acetate (300 mL x 3) and the organic phases were combined and washed sequentially with water and brine. The organic layer was dried with anhydrous Na2SO4, filtered and purified by column chromatography (n-hexane: ethyl acetate=3:1) to give a light yellow solid product (343.0 mg, yield 35.40%). Melting point: 77-79°C; IR (KBr pressed sheet, cm^-1): 3373, 3326, 1663, 1296; 1H NMR (400 MHz, CDCl3): δ 7.53 (m, 2H), 6.69 (m, 1H), 3.41 (s, 2H), 2.43 (s, 3H).
References
[1] Patent: WO2006/101318, 2006, A1. Location in patent: Page/Page column 44; 83-84
[2] Patent: EP1862454, 2007, A1. Location in patent: Page/Page column 6; 18
1-(4-amino-3-fluorophenyl)ethan-1-one Preparation Products And Raw materials
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View Lastest Price from 1-(4-amino-3-fluorophenyl)ethan-1-one manufacturers
- Product
- 1-(4-amino-3-fluorophenyl)ethan-1-one 73792-22-0
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24