ChemicalBook > CAS DataBase List > oxypyrronium bromide

oxypyrronium bromide

Product Name
oxypyrronium bromide
CAS No.
561-43-3
Chemical Name
oxypyrronium bromide
Synonyms
LD3055;LD-3055;LD 3055;L.D. 3055;Immetropan;Oxypyrronium;OxipyrroniumBromide;oxypyrronium bromide;(1,1-dimethylpyrrolidin-1-ium-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate bromide;(1,1-dimethylpyrrolidin-1-ium-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate bromide
CBNumber
CB0884387
Molecular Formula
C21H32BrNO3
Formula Weight
426.38768
MOL File
561-43-3.mol
More
Less

Safety

Toxicity
LD50 oral in rat: 780mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0312776
Product name
OXYPYRRONIUM BROMIDE
Purity
95.00%
Packaging
5MG
Price
$503.26
Updated
2021/12/16
More
Less

oxypyrronium bromide Chemical Properties,Usage,Production

Originator

Oxypyrronium ,Shanghai Lansheng

Manufacturing Process

The 1-methyl-2-hydroxymethylpyrrolidine was obtained by the process of Application No 21193/56 (Serial No. 820,503).
A methanolic solution of sodium methoxide [from sodium (0.6 g) and methanol (15 ml)] was added dropwise during 3 h to a boiling solution of methyl phenylcyclohexylglycollate (33.7 g) and 1-methyl-2hydroxymethylpyrrolidine (23.4 g) in heptane (400 ml) and the methanol that separated was removed by means of a Dean and Stark apparatus. At the end of 4 h no further separation of methanol occurred and the solvent was removed under reduced pressure. The residue was dissolved in either and the etheral solution, after washing with water (3 x 50 ml), was extracted with 5 N hydrochloric acid (3 x 100 ml). The (1-methyl-2-pyrrolidyl)methyl phenylcyclokexylglycollate hydrochloride (35.5 g 71%) crystallised out of the acid extract as colourless needles, melting point 181°-196°C. Extraction of this hydrochloride (33.0 g) with hot ethanol (150 ml) left the sparingly soluble (1-methyl-2-pyrrolidyl)methyl phenylcyclokexylglycollate hydrochloride (aform) (7.6 g), melting point 220°-222°C.
The (1-methyl-2-pyrrolidyl)methyl phenylcyclokexylglycollate hydrochloride (aform) (15.0 g) was dissolved in water, basified with sodium hydroxide solution and the resultant oil extracted into ether. The extracts were dried over magnesium sulfate, the ether evaporated and the residue dissolved in acetone (100 ml). Methyl bromide (7.8 g, 2 mole) was added to the acetone solution and the mixture warmed on a steam bath for 15 min. The solution was cooled and the solid filtered off, washed with a little acetone and dried to give the (1,1-dimethyl-2-pyrrolidyl)methyl α-phenylcyclokexylglycollate bromide, melting point 185°-186°C. (86%).

Therapeutic Function

Anticholinergic, Spasmolytic

oxypyrronium bromide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

oxypyrronium bromide Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
15229059051
Email
1027@dideu.com
Country
China
ProdList
9982
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19711
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19863
Advantage
58

561-43-3, oxypyrronium bromideRelated Search:


  • oxypyrronium bromide
  • Oxypyrronium
  • OxipyrroniumBromide
  • (1,1-dimethylpyrrolidin-1-ium-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate bromide
  • (1,1-dimethylpyrrolidin-1-ium-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate bromide
  • 2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid (1,1-dimethylpyrrolidin-1-ium-2-yl)methyl ester bromide
  • Immetropan
  • L.D. 3055
  • LD 3055
  • LD3055
  • LD-3055
  • 561-43-3