2-Cyclohexylmandelic acid
- Product Name
- 2-Cyclohexylmandelic acid
- CAS No.
- 4335-77-7
- Chemical Name
- 2-Cyclohexylmandelic acid
- Synonyms
- rcc32;kl-007-m1;lespedamine;-2-hydroxy-phenyL;CYCLOHEXYLMANDELIC;TIMTEC-BB SBB008619;Oxybutynin Impurity D;hexahydrobenzilicacid;2-Cyclohexylmennic acid;CYCLOHEXYL MANDELIC ACID
- CBNumber
- CB7472035
- Molecular Formula
- C14H18O3
- Formula Weight
- 234.29
- MOL File
- 4335-77-7.mol
2-Cyclohexylmandelic acid Property
- Melting point:
- 163 °C
- Boiling point:
- 135℃/3mm
- Density
- 1.206±0.06 g/cm3(Predicted)
- RTECS
- GV2770000
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Sparingly)
- form
- Solid
- pka
- 3.49±0.25(Predicted)
- color
- White to pale brown
- CAS DataBase Reference
- 4335-77-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- PHR2548
- Product name
- Oxybutynin Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 200 mg
- Price
- $683.05
- Updated
- 2025/07/31
- Product number
- BP703
- Product name
- Phenylcyclohexylglycolic acid
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 25MG
- Price
- $272
- Updated
- 2025/07/31
- Product number
- 706418
- Product name
- α-Cyclohexylmandelic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $59.8
- Updated
- 2025/07/31
- Product number
- 1485114
- Product name
- Oxybutynin Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100mg
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- C2393
- Product name
- alpha-Cyclohexyl-DL-mandelic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $70
- Updated
- 2025/07/31
2-Cyclohexylmandelic acid Chemical Properties,Usage,Production
Description
This indole alkaloid occurs in the leaves of Lespedeza bicolor var. japonica and, when pure, is a colourless oil. Its MeOH solution, the ultraviolet spectrum exhibits absorption maxima at 223.4, 279 and 291 mJi. The crystalline hydrochloride has m.p. 163-4°C (dec.); the picrate forms long, yellow needles from MeOH, m.p. 160-2°C (dec.) and the styphnate, also yellow needles, has m.p. 170°C (dec.). The structure has been established as 3-(dimethylaminoethyl)-1-methoxyindole.
Chemical Properties
White Solid
Uses
An intermediate in the synthesis of oxybutynin (O868525). Oxybutynin USP Related Compound A.
Uses
intermediate for Oxybutynin HCl, Oxyphenonium Bromide
Definition
ChEBI: Alpha-Cyclohexylmandelic acid is a member of benzenes.
Synthesis
31197-69-0
4335-77-7
General procedure for the synthesis of 2-cyclohexyl-2-hydroxyphenylacetic acid from oxybutynin impurity 2: To a solution of methanol (20 mL) containing cyclohexyl-hydroxy-phenylacetic acid (1.04 g, 3.96 mmol) was added a 1N NaOH solution (8 mL). The reaction mixture was heated to 80 °C and stirred continuously for 3.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted with ether. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and finally concentrated under reduced pressure to give the crude product as a white solid. Purification of the crude product by recrystallization from a solvent mixture of hexane and dichloromethane afforded 900 mg of 2-cyclohexyl-2-hydroxyphenylacetic acid in 97% yield. The structure of the product was confirmed by 1H-NMR (CDCl3).
References
Morimoto, Oshio., Annalen, 682, 212 (1965)
2-Cyclohexylmandelic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Cyclohexylmandelic acid manufacturers
- Product
- 2-Cyclohexylmandelic acid 4335-77-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 2-Cyclohexylmandelic Acid 4335-77-7
- Price
- US $8.70/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20
- Product
- 2-Cyclohexylmandelic acid 4335-77-7
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10MT
- Release date
- 2018-12-21