bicozamycin
- Product Name
- bicozamycin
- CAS No.
- 38129-37-2
- Chemical Name
- bicozamycin
- Synonyms
- C11259;WS-4545;ICOZAMYCIN;bicozamycin;BicycloMycin;BicozaMycin benzoate;BicozaMycin, AizuMycin, Bacteron, CGP 3543E, WS4545, 5879;(1R,6S)-1-hydroxy-2-methylidene-6-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-5-oxa-8,10-diazabicyclo[4.2.2]decane-7,9-dione;2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6R)-
- CBNumber
- CB0895983
- Molecular Formula
- C12H18N2O7
- Formula Weight
- 302.28
- MOL File
- 38129-37-2.mol
bicozamycin Property
- Melting point:
- 188-191° (dec); mp 187-189° (dec) (Imanaka); mp 166-170° (Nakatsuka et al.)
- alpha
- D23 +63.5° (methanol)
- Boiling point:
- 786.6±60.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- pka
- 9.85±0.60(Predicted)
Safety
- Toxicity
- LD50 in mice: >4 g/kg (Williams, Durham)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0015110
- Product name
- BICOZAMYCIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $2203.43
- Updated
- 2021/12/16
bicozamycin Chemical Properties,Usage,Production
Uses
Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites. The primary site of action for bicyclomycin is thought to be the rho transcription termination factor.
Definition
ChEBI: A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.
Origin
Bicozamycin, formerly called bicyclomycin, was found independently in 1972, in the cul ture broth of Streptomyces sapporonensisbyFu jisawa Pharmaceuticals Industries and in that of S. aizuensis by Miyamura et al. of Ni igata University.
Biological Activity
Bicozamycin has a unique bicyclic structure and shows activity against Kleb siella, Salmonella, and Shigella but noneagainst other gram-negative bacteria or gram-positive microorganisms.
Safety
Bicozamycin is not absorbed orally and showsverylowtoxicity;nomicedied following its intravenous injection at a dose as high as two grams per kilogram.
bicozamycin Preparation Products And Raw materials
Raw materials
Preparation Products
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